The Kaag Rasmussen lab at the Center for Translational Neuromedicine is looking for a highly motivated postdoc candidate to study CSF and extracellular signaling pathways in migraine. The role includes proteomics, transcriptomics, behavior, and in vivo imaging. APPLY below (MKG)
Vittani, Lee, Wang, Hiraoka, et al.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025.03.18.6…
We hope this method is useful to a wide range of the biology community.
Out today in @CellCellPress !
We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 cell.com/cell/fulltext/S0092…
How can understanding brain waste flow inform brain health?
Prof Douglas Kelley, PhD, of Mechanical Engineering @UofR Hajim, aims to understand the glymphatic system so conditions like #Alzheimer's and #Parkinson's can be studied more effectively. #URochesterResearch In a Neuro Minute🧠
Virally Induced CRISPR/Cas9-Based Knock-In of Fluorescent Albumin Allows Long-Term Visualization of Cerebral Circulation in Infant and Adult Mice
link.springer.com/protocol/1…|
Marta Vittani, Philip Aleksander Gade Knak, Masahiro Fukuda, Masaki Nagao, Xiaowen Wang, et al.
Online now! Cervical lymphatics drain CSF and clear metabolic waste from the brain. Du et al., show using 2P-OPTIC that these are disrupted in aging due to reduced pumping. Restoring cervical lymphatic function with PGF2a rescues brain clearance. doi.org/10.1038/s43587-024-0…
#URochesterResearch via @NatureAging shows how
scientists restored the brain’s ability to clear toxic waste in older mice with a drug that's currently used to induce labor. This points to a potential new treatment for #Alzheimers and #Parkinsons.
Paper: go.nature.com/46WCR8F
👇Watch the aging lymphatic system – less contractions in the older mouse (right) causing the waste to stop and flow in different directions.
A new Science study in mice identifies a novel non-synaptic signaling mechanism between the brain and peripheral sensory system important for migraine.
Learn more ⬇️
📄: scim.ag/7D5#SciencePerspective: scim.ag/7D4