lets help protect and support each other this is a really hard time for us all. Personal account / my views.
Joined June 2009
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Apr 10
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New preprint! We show that intranasal nose drops of mRNA-LNP can deliver therapeutic peptides to the brain, and we used this to reduce pain and increase social behaviour in mice. This could be a whole new class of non-opioid pain treatments. doi.org/10.64898/2026.03.18.… 1/9
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Greg Neely retweeted
May 31
There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
nejm.org/doi/full/10.1056/NE…
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Jun 1
1/ New preprint from the lab, led by Maria Bergamasco!
We've developed a way to deliver BDNF directly to the brain using nose drops. Weekly dosing rejuvenates an old mouse's brain and blocks memory loss in a mouse model of Alzheimer's disease.
doi.org/10.64898/2026.04.19.…
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Jun 1
9/ A paper out in ACS Nano from Yu, Deng and colleagues (Cheng, Teng, Wei labs) shows the same general approach works in a different disease setting. Two independent groups, different disease models, same conclusion: intranasal mRNA-LNP of neurotrophic factors works.
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Jun 1
10/ This is a platform. BDNF (and Oxytocin previously) is our proof of concept, but the same approach should work for other secreted proteins relevant to brain disease.
This is a preprint not yet peer reviewed, feedback welcome.
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Greg Neely retweeted
Apr 21
If you want to join us for the venom GRC in Barcelona next month, late registration is open until Sunday this week. Don't miss it! grc.org/venom-evolutio…
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Apr 10
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New preprint! We show that intranasal nose drops of mRNA-LNP can deliver therapeutic peptides to the brain, and we used this to reduce pain and increase social behaviour in mice. This could be a whole new class of non-opioid pain treatments. doi.org/10.64898/2026.03.18.… 1/9
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Apr 10
We're now moving this technology towards commercialization and human trials through our spinout company Enhanced Analgesics. We've shown this works across multiple animal models — the next step is getting it into the clinic. 8/9
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Apr 10
Great work from co-first authors @LLTheResearcher and Kazuma Fujikake and the whole team @CPC_usyd @Sydney_Science @UNSWRNA, @CSIRO and @UofT.
This is a preprint and not yet peer reviewed. We look forward to feedback from the community!
doi.org/10.64898/2026.03.18.…
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