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Kekenes-Huskey Lab @PKH_Lab

Account for the Kekenes-Huskey lab at the Loyola University Chicago

Joined October 2018
  • Tweets 81
  • Following 157
  • Followers 162
15 Photos and videos
How might myofilament-associated proteins with intrinsic disorder (MAPID) contribute to length-dependent activation in cardiomyocytes? Check out our study for details: shorturl.at/6R1J6

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

This work bridges molecular disorder and biomechanical function, providing a new lens to understand dynamic control and dysfunction in cardiomyocyte contra

rupress.org
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New paper! We built a Bayesian hierarchical mixture model to capture the hidden diversity in calcium signaling across single cells. Free access: authors.elsevier.com/c/1lL3E…
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How does the heart adapt to demand? Our research explores how phosphorylation in disordered regions of ABLIM1 impacts its shape and interactions, revealing new insights into cardiomyocyte contraction regulation: biorxiv.org/content/10.1101/…

Molecular mechanisms of GSK3β-driven modulation of ABLIM1 and titin interactions in cardiac muscle

The heart adapts to cardiac demand through a variety of mechanisms. Some of these adaptations include chemical modifications of myofilament proteins responsible for cell contraction. Interestingly,...

biorxiv.org
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I'm deeply honored to have presented at the 29th Xing Han Symposium for the 100th anniversary of Harbin Medical University, alongside Prof. Gao (Chinese Academy of Sciences) and Prof. Wu (Sun Yat-sen U.)
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I was invited to present our lab's simulation work on the myofilament protein ABLM1 at this year's meeting of #istcp2024 in Qingdao, China! Happy to also visit with my colleague Yi Wang from the Chinese U. of Hong Kong.
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Very proud that our productive summer student Brandon Goh Beh won the award for the best poster at #NOBCChE51 !
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Our teams show tumor-associated macrophages (TAMs) can be reprogrammed to fight cancer by switching from a tumor-supporting (M2) to an anti-tumor (M1) state. doi.org/10.1002/adhm.2024019… #CancerResearch #TumorMicroenvironment #Macrophages #Immunotherapy #ResearchInnovation

Organelle Specific Macrophage Engineered Vesicles Differentially Reprogram Macrophage Polarization

Vesicles engineered from cellular organelles can modify macrophage polarization. Vesicles derived from the endoplasmic reticulum are more effective than those generated from the plasma membrane.

advanced.onlinelibrary.wiley.com
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a rich discussion on the esoteries of myofilament structure. #myofilament
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We contributed simulations of TNNI1 variants, the slow-twitch troponin I isoform, identified in families with muscle-related disorders. Further indication of the important roles unstructured regions in myofilament proteins play in human disease! science.org/doi/abs/10.1126/…

Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile...

TNNI1 variants may cause early-onset muscle disease with variant-specific pathomechanisms that are amendable to therapeutic interventions.

science.org
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We are excited to share that Emily Krueger has been awarded a Travel Award from the committees for Inclusion and Diversity, Professional Opportunities for Women, Education, Early Careers, and Membership to present her abstract at the 2024 Biophysical Society!
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Congrats to Xuan Fang, Ph.D. for publishing a computational paper exploring the molecular basis of myosin light chain kinase activation by calmodulin (pubs.acs.org/doi/full/10.102…)! This study provides insights into engineering calmodulin for regulating cell contraction.

Molecular Insights into the MLCK Activation by CaM

Calmodulin (CaM) is a universal regulatory protein that modulates numerous cellular processes by using calcium (Ca2 ) as the signal. In smooth muscle cells (SMC), one major target of CaM is myosin...

pubs.acs.org
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We contributed to a study of the ACTN2 gene and a missense variant (A868T) affecting structure & function. Reports ultrastructural changes, increased Ca2 sensitivity of force generation, with implications for cardiac disease #CardiologyResearch. mdpi.com/1422-0067/24/19/145…

Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a...

The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of unknown significa...

mdpi.com
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Wrapping up an exciting stay in Chapel Hill to learn about zebrafish physiology. Many thanks to the Celia Shiau lab for hosting us!
a budding researcher

ALT a budding researcher
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robotic zebrafish feeders in action during my mini sabbatical
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Congrats to Emily for successfully defending her qualifying proposal!
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Visited @ukychem to see old colleagues and ongoing collaborators (including one with a just-accepted article doi.org/10.1002/adhm.2023011…).
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Enhancing LQTS variant classification (doi.org/10.1016/j.yjmcc.2023…)! Using simulations/machine learning, we predict KCNH2 missense variants' trafficking. Structural features play a crucial role, advancing of understanding congenital long QT syndrome. #LQTS #Genetics #Simulation"
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"New article published! Delve into the complexity of Ca2 signal transduction by Calmodulin (CaM), including disease mutations, conserved amino acid sequences, and interdisciplinary insights. #CaM #SignalTransduction #Research" doi.org/10.1016/j.ceca.2023.…
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PKH is excited that the lab has received an R35 MIRA award from NIH entitled "Probing macrophage cell nucleotide sensing and calcium signaling through computation"!! This grant will support impactful studies combining cell biology in our wetlab with extensive computer modeling
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Stay tuned for job postings at the technician, graduate student, and postdoctoral levels to support our research: (pkhlab.sites.luc.edu/opening…)
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