SGLT2i and GLP-1RA are no longer just glucose-lowering drugs — they are cardio-renal-metabolic protective agents and should be prescribed as such.
Cardiovascular, Kidney & Metabolic diseases are one interconnected loop
Treat the syndrome, not just the organ.
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Proton pump inhibitors were associated with exacerbations of chronic obstructive airway diseases in a recent study. "These results support using the lowest effective PPI dose for the shortest possible duration," writes Molly S. Brett, MD. Full summary: jwat.ch/4dXVvRp
ALT An illustration of chronic obstructive airway diseases showing human lungs. A proton pump inhibitor container is connected by an arrow to two magnified circles, depicting airway constriction and airway inflammation.
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Only about 1 in 10 Americans eat the recommended amount of vegetables each day. The good news: small changes can make a big difference. From healthy salads to sneaking more veggies into meals, the American Heart Association shares practical tips to help you add more color to your diet: spr.ly/6014B8CGSC
New in #EJPC: Disability is associated with higher cardiovascular risk even in young adulthood.
In adults aged 20–39 years, long-standing disability was linked to a 34% higher risk of CVD, independent of conventional risk factors. Risk was highest in brain lesion-related disability and increased with disability severity and duration.
A call for earlier and more inclusive prevention.
♿🫀ow.ly/16YB50ZbpxG@EJPCEiC@AboyansV@SilCastelletti@PTBuketAkinci@PeroneFrancesco@SMosteoru@TimKambic
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Managing high blood pressure often starts with small, steady changes. Choosing healthier foods, moving more during the week, and limiting salt intake can all help your heart work more efficiently over time. Learn more here: spr.ly/6015B8CyA9
☝️Oral PCSK9 Inhibitors: A New Era in Lipid-Lowering Therapy?
👉Key takeaways:
1️⃣ Enlicitide (MK-0616) reduced LDL-C by ~56% in Phase III trials, with additional reductions in apoB, non-HDL-C, and Lp(a), showing efficacy comparable to injectable PCSK9 monoclonal antibodies.
2️⃣ Laroprovstat (AZD0780) achieved up to 50% LDL-C reduction and is currently advancing through Phase III development (AZURE Outcomes program), representing another highly promising oral PCSK9 inhibitor.
3️⃣ Other emerging oral agents—including DC371739, CVI-LM001, CiVi008, and the previously studied NNC0385-0434—highlight the growing diversity of strategies targeting the PCSK9 pathway and related lipid-regulating mechanisms.
👉The future may lie in simplified oral combination therapy: a statin ezetimibe oral PCSK9 inhibitor could potentially achieve 70–80% LDL-C reduction, bringing injectable-level efficacy into a convenient all-oral regimen.
👉 Ongoing cardiovascular outcome trials will determine whether these impressive lipid improvements translate into reductions in major cardiovascular events.
☝️Bottom line:
The next generation of lipid-lowering therapy may not be another injection—but a powerful triple oral combination capable of transforming cardiovascular prevention.
🔓🔗 academic.oup.com/eurheartjsu…@society_eas@nationallipid@ESC_Journals@escardio
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W Białymstoku zakończyła się VIII Konferencja Naukowo-Szkoleniowa @neurologiczne Miałem zaszczyt mieć pierwszy wykład o logistyce opieki udarowej i zakończyć sesją z Prof. Sławomirem Michalakiem i Prof. Michałem Karlińskim o #cerebrolizyna@PTChCpl@WMCM_UKSW@IPiN_Warszawa
Główne przyczyny MetALD to nieprawidłowy styl życia (m.in. niewłaściwe odżywianie się czy brak regularnej aktywności fizycznej⛹🏻), nadwaga/otyłości, nadciśnienie tętnicze, hipercholesterolemia, cukrzyca oraz regularne spożywanie 🥂🍺🍷
@AASLDtweets@MZ_GOV_PL
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🇵🇱🇪🇺 | I'm truly humbled to be back at my Alma Mater - Medical University of Warsaw 🩺👨🏻⚕️ It was pleasure to be a reviewer of PhD thesis and attend the PhD defense 🤝 Thank you very much for inviting me 🙏🏻
@WMCM_UKSW@MZ_GOV_PL@PTChCpl
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💭 Daraxonrasib - jedna z największych nadziei w leczeniu raka trzustki. Po raz pierwszy od wielu lat mamy lek, który wydłuża życie w zaawansowanym raku trzustki. Redukcja ryzyka zgonu: ⬇️ 60% (HR 0.40; 95%CI 0.3-0.54;p<0.001) - prof. @FilipMSzymanski@MZ_GOV_PL@MDobrolowicz
There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicinesnejm.org/doi/full/10.1056/NE…
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Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM@ASCO
ALT Graph from a study published in the New England Journal of Medicine on daraxonrasib versus chemotherapy for metastatic pancreatic cancer. The x-axis represents months, and the y-axis shows the percentage of patients alive. Two lines indicate survival rates: daraxonrasib (blue) and chemotherapy (gray). The bottom section lists patients at risk over time. Title and journal logo are included.
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In HER2-positive gastroesophageal adenocarcinoma, progression-free survival was longer with zanidatamab plus chemotherapy, both with and without tislelizumab, than with trastuzumab plus chemotherapy. Full HERIZON-GEA-01 trial results are summarized in a new Quick Take. nej.md/4dPdxFs
ALT A silhouette of a person with a highlighted stomach. A magnified view shows human epidermal growth factor receptor 2. To the side, medical supplies including two vials and an IV bag are displayed, representing zanidatamab plus tislelizumab plus chemotherapy.
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ALT JAMA Cardiology Research Letter: Extended Low-Dose Apixaban and Superficial Vein Thrombosis: Post Hoc Analysis of the HI-PRO Randomized Clinical Trial. Two cumulative incidence curves compare Apixaban 2.5mg & Placebo for primary (P=.04) & secondary (P=.14) outcomes, showing lower event rates with Apixaban. Number at risk tables included.
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Original Article: PARP and Androgen-Signaling Inhibition plus ADT in Metastatic Prostate Cancer (phase 3 TALAPRO-3 trial) nej.md/4nRSB5n
Editorial: Precision Intensification in Metastatic Prostate Cancer nej.md/4fMp9vv#ASCO26 | @ASCO
ALT This image shows three Kaplan-Meier survival curves comparing talazoparib plus enzalutamide versus placebo plus enzalutamide across different subgroups over months. Each graph represents a different subgroup: Intention-to-Treat Population, BRCA Subgroup, and Non-BRCA Subgroup. The x-axis is in months, and the y-axis represents the percentage of patients. Data points are annotated with the number of events and median imaging-based progression-free survival times.
ALT A four-panel graph illustrating the secondary efficacy end points. Panel A shows overall survival, with a line graph comparing talazoparib–enzalutamide and placebo–enzalutamide over 56 months. Panel B displays a line graph of confirmed PSA progression. Panel C features a line graph detailing subsequent antineoplastic therapy. Panel D is a bar graph depicting the objective response, with categories for complete response, partial response, stable disease, and progression, comparing both treatment groups.
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As we age, especially after 60 years, there is a marked accumulation of mutations in our mitochondrial DNA. These are undetected (cryptic) until they expand into clones and, while associated with clonal hematopoiesis (CHIP), they may independently have an impact on health outcomes @Naturenature.com/articles/s41586-0…
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Published today, Vascular Contributions to Cognitive Impairment (VCID) and Brain Health: Clinical Update and Mechanistic Considerations.
This paper proposes that multi-mechanistic origins of VCID and time-appropriate interventions that complement VRFs modification are important to maintaining brain health and preserving cognitive function across the lifespan.
📷 Conceptual diagram of vascular contributions to age-related cognitive decline and worsening brain health.
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Trial evidence from 17 trials in people without ASCVD including statins and non statins in 105 000 individuals about why you get a bigger benefit from starting prevention early . AJPC open access
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📊Exploratory analyses of TRACE‑III
💉Tenecteplase (4.5–24h) may benefit late-window stroke patients without thrombectomy
👉❗️Effect depends on infarct growth rate
Read more here👇
journals.sagepub.com/doi/abs…