@PenmatsaLab profile picture
Aravind Penmatsa @PenmatsaLab

Associate Professor at the Molecular Biophysics Unit, IISc

Joined February 2021
  • Tweets 608
  • Following 107
  • Followers 1,316
13 Photos and videos
Thank you @DBTIndia for the opportunity to contribute to the discussion in this panel at #IndiaAIImpactSummit2026.
Dataquest@dataquestindia
Feb 16
At the India AI Impact Summit, the BioAI conversation made one thing clear: AI isn’t just “speeding up biology" it’s reshaping how we design, test, and scale biomanufacturing. dqindia.com/news/india-ai-su… #Dataquest #BioAI
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Interested students should apply to this cycle of MBU PhD admissions. MBU runs one of the best Biophysics Phd programs in the country and there is a renewed emphasis on AI/ML use in biophysics and drug discovery from multiple groups this year. Don't miss out!
Molecular Biophysics Unit, IISc@MBU_IISc
Feb 12
Applications for @iiscbangalore admissions 2026 are open! Our department invites applications for the Ph.D. program. Apply to join our vibrant research community. Deadline: Mar 23, 2026
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Smruti Nayak @SmrutiR60158682 a highly productive and successful grad student is moving to @YaleMed to work with @GuptaLab1. Members of the @PenmatsaLab wish him the best for a wonderful research career ahead.
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Aravind Penmatsa retweeted
Shubhasis Haldar@HaldarShubhasis
3 Oct 2025
We’re organizing Biophysics Today from 2–4 Dec at SNBNCBS, featuring 29 distinguished speakers from across disciplines. Three days of exciting discussions on the latest in biophysics — looking forward! #BiophysicsToday #SNBNCBS
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It was wonderful to have @iDikic2 at @iiscbangalore on 31st January. Ivan gave a fantastic talk on ubiquitination and ERphagy at Biological sciences and interacted with colleagues. linkedin.com/posts/ivan-đik…

#ubiquitin #autophagy #science #embo #india | Ivan Đikić | 14 comments

Pleasure to visit the Indian Institute of Science (IISc) in Bangalore, a cradle of molecular biology in India (established in 1909) and today one of the most successful Indian institutes. It was a...

linkedin.com
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Aravind Penmatsa retweeted
DBT/WT India Alliance@India_Alliance
6 Jan 2025
🎉 Looking back at our IA Awardees who made waves in 2024! 👏We're proud of their groundbreaking research and contributions to their respective fields of research. Learn more: dbtindiaalliancenew.s3.ap-so… @DBTIndia @PrinSciAdvGoI @wellcometrust @rajesh_gokhale @jarottingen
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Many thanks to @India_Alliance for showcasing our research and supporting us over the years!
DBT/WT India Alliance@India_Alliance
9 Sep 2024
Today, we present the work of our DBT/WT Senior Fellow, Prof Aravind Penmatsa @PenmatsaLab. Read our story about their team's work at @MBU_IISc @iiscbangalore: indiaalliance.org/news/resea… @DBTIndia @wellcometrust #IndiaAllianceFellows
Aravind (centre) and his group members are involved in understanding transport across cell membranes in the Penmatsa Lab at the Molecular Biophysics Unit, Indian Institute of Science, Bengaluru. Picture credit. Yukti Saini

ALT Aravind (centre) and his group members are involved in understanding transport across cell membranes in the Penmatsa Lab at the Molecular Biophysics Unit, Indian Institute of Science, Bengaluru. Picture credit. Yukti Saini

This schematic depicts neurotransmitter transport at the neural synapse mediated through ion-coupled transporters and their roles in establishing the neurotransmitter cycle. Cellular metabolites like ATP are released to the external environment through channels called pannexins, leading to cell death.

ALT This schematic depicts neurotransmitter transport at the neural synapse mediated through ion-coupled transporters and their roles in establishing the neurotransmitter cycle. Cellular metabolites like ATP are released to the external environment through channels called pannexins, leading to cell death.

High-resolution structures of GAT1, a neurotransmitter transporter bound to an antibody; QacA, a multi-drug efflux transporter bound to single domain antibodies; and Pannexin 3, a large pore ion channel studied by the Penmatsa lab.

ALT High-resolution structures of GAT1, a neurotransmitter transporter bound to an antibody; QacA, a multi-drug efflux transporter bound to single domain antibodies; and Pannexin 3, a large pore ion channel studied by the Penmatsa lab.

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Excellent initiative to accelerate biotech research and Innovation!
Rajesh Gokhale@rajesh_gokhale
24 Aug 2024
Exciting times ahead for Biotech innovation in India
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Aravind Penmatsa retweeted
President of India
@rashtrapatibhvn
22 Aug 2024
President Droupadi Murmu presents Vigyan Yuva- Shanti Swarup Bhatnagar Awards to: · Dr Krishna Murthy S L in Agricultural Sciences · Dr Swarup Kumar Parida in Agricultural Sciences · Prof. Radhakrishnan Mahalakshmi in Biological Sciences Prof. Aravind Penmatsa in Biological Sciences
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Before I receive the VY-SSB award from Hon. @rashtrapatibhvn it is important for us @PenmatsaLab to acknowledge the funding agencies that have reposed faith in our research. Deeply grateful to @DBTIndia @India_Alliance @IndiaDST @EduMinOfIndia @EMBO_YIP
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Deeply grateful to @govofindia for this selection. My gratitude to my mentors, colleagues @MBU_IISc , students and family for their unwavering support. A special thanks to all past and present @Penmatsalab members who made this happen. Congratulations to all winners of RVP2024.
IISc Bangalore@iiscbangalore
8 Aug 2024
Congratulations to faculty members who have received the Rashtriya Vigyan Puraskar 2024!🎉 Prof G Padmanaban is the first to receive the Vigyan Ratna for lifetime achievement. Prof Umesh Varshney receives Vigyan Shri, and Profs Aravind Penmatsa & Mahesh Kakde receive Vigyan Yuva.
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Excellent work on P2X7 receptor by my dear friend @mansoor_steven and his lab @MansoorLabOHSU. Congratulations.
MansoorLab@MansoorLabOHSU
6 Aug 2024
We are very happy to share some work we just had published in Nature Communications. Congratulations to the whole team but especially to Adam Oken, the first author on the paper. nature.com/articles/s41467-0…
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Greatly pleased to announce the publication of our study on Pannexins in @NatureComms . Kudos to @Nazia_hussain7 for her superlative effort. She was ably supported by Ashish Apotikar and others to complete this challenging study. nature.com/articles/s41467-0…

Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms

Nature Communications - Pannexins are large pore channels involved in ion and ATP release. Here the authors use cryo-EM structures of Pannexins 1 and 3 to demonstrate the effects of distinct...

nature.com
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A special thanks to our collaborators Sujit Sikdar @MBU_IISc and Vinothkumar @NCBS_Bangalore for their support and help. The manuscript delves into the differences among Pannexin isoforms 1 and 3 and the importance of pore-lining residues in controlling channel function.
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We also observe allosteric effect of a germline mutant of Pannexin 1 that causes partial pore closure. Funding from @EduMinOfIndia @India_Alliance @DBTIndia is greatly acknowledged. A special thanks to CryoEM facilities at @BLiSC_India , @iiscbangalore and @esrfsynchrotron.
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Aravind Penmatsa retweeted
Membrane Protein PDB@MemProtPDB
2 Apr 2024
High resolution cryo-EM of V-ATPase in native synaptic vesicles | bioRxiv biorxiv.org/content/10.1101/…
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A warm farewell to @nazia_hussain7 who is leaving @MBU_IISc and @PenmatsaLab today for her postdoc @uniGoettingen. Nazia contributed immensely to the growth of the lab and its projects besides doing excellent research on large pore ion channels.
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Much needed support! Way to go EMBO!!
EMBO@EMBO
20 Mar 2024
EMBO announces the launch of a pilot scheme to support Open Access #OA publication by life scientists performing their #research in #India. embo.org/features/support-fo…
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Hearty Congratulations to @hussainnazia64 for her poster prize at the just concluded #IBS2024 at UoH and @TIFRH_buzz. Receiving it from Vasanthi Jayaraman @frettinglab makes it even more special. Watch this space for future updates on Nazia's research on Pannexins.
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A must read for anyone working with transporters!
Boudker Lab@BoudkerLab
1 Mar 2024
Transporter aficionados unite! In @Nature, @OlgaBoudker and David Drew provide a comprehensive review of how secondary active transporters can couple substrate transport to ion gradients, and how lipids can regulate transport mechanisms. nature.com/articles/s41586-0…
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