Assoc. Prof @PennMedicine | Rare-disease dad. Trying to fix hearts AND brains. Myocytes, Microtubules, Heart Failure | ASOs, RNA, NeuroDevelopmental Disorders.
Joined March 2020
- Tweets 406
- Following 255
- Followers 1,587
- Likes 1,091
75 Photos and videos
Pinned Tweet
7 Feb 2023
What a privilege to have the team and opportunity to try and help my daughter and those like her live healthier, fuller lives. We will be a relentless force for good against #RareDisease.
@IngoHelbig @lab_davidson @ChildrensPhila @PennMedicine tinyurl.com/yf649bcc
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Ben Prosser retweeted
13 Nov 2024
Prof. Benjamin L. Prosser and his team at the @Prosser_Lab at @PennMedicine are researching the heart on a molecular level. Learn more about how his personal story motivated him to work on transformative cardiac and gene research.
Visit zeiss.com/prosser
#Health
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Ben Prosser retweeted
15 Oct 2024
@LucieCarrier84 lab provide evidence that targeting #tubulin #tyrosination could be a novel approach for improving heart function in patients with #HCM. Learn more at ahajrnls.org/3A2ZuMP
@Prosser_Lab @mcaporizzo @CyxChristina @dirkwestermann @LucasBacmeister
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Ben Prosser retweeted
14 Oct 2024
This study, conducted in close collaboration with @curestxbp1, aimed to identify the rate & causes of early mortality in #STXBP1-related disorders.
These results are important for family & prognostic counselling💜
@FrancescaFuria_ @Elegardella 👏
link.springer.com/article/10…
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19 Aug 2024
$$$ for #RareDisease research!
RFAs for 35 different rare disorders through the @ODC_UPenn, including 2 x $70K grants available to @curestxbp1 courtesy of Lulu's Crew :)
Info and app link here: bit.ly/MDBR2024RFA
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Ben Prosser retweeted
25 Jul 2024
Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab @Prosser scim.ag/7Nf
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24 Jul 2024
Want to know more about what ENDD is doing for rare 🧠disorders like @cureSYNGAP1 and @curestxbp1?
Updated website here! endd.med.upenn.edu
@ChildrensPhila @PennMedicine @lab_davidson @IngoHelbig @EAHellerPhD
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19 Jul 2024
Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab
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tinyurl.com/ynn6r2mz
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19 Jul 2024
In vivo, overnight VASHi was well tolerated, and improved ventricular relaxation and diastolic function in advanced HFpEF. (opinion - that's pretty cool for just targeting a microtubule PTM!) 4/5
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19 Jul 2024
Next big step - determine chronic efficacy (and safety!) with sustained treatment to prevent progression of HFpEF (and other forms of HF). Awesome effort from @tweetineaton @MCaporizzo and Ben Lee.
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Ben Prosser retweeted
27 Jun 2024
@Prosser_Lab @Rongtian2
The traditional #GRC soccer game ⚽️ 🥅
#GRCcardiac2024
#CardiacRegMechanisms
#ColbySawyerCollege
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Check out our new paper @jclinicalinvest by the great @Ramihdd and @shkedio. We show that the protein RPSA is required for ribosome localization, localized translation, and the maintenance of the sarcomere. dlvr.it/T6vjhn
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3 May 2024
Happy birthday Lu!
6 years - and now standing by yourself!
I have too many feelings to tweet, so I'll just say THANK YOU to everyone who has supported Lucy, or who is fighting to improve the lives of those with #raredisease. Keep going.
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2 May 2024
Keep going Brett.
30 Apr 2024
Someone asked me about the scratches I had on my faces during a recent video. Living life trying to @cureSYNGAP1 isn't always easy, but Emmitt's always worth it.
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13 Mar 2024
Don't miss the premier conference for fundamental and translational cardiac research! Program in link, still with open talk slots to be selected from abstracts.
#CardioTwitter @Rongtian2 @KimHellgren @Heart4Carolina
grc.org/cardiac-regulatory-m…
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11 Mar 2024
These are BEAUTIFUL 👏tissue mechanics in living myocardial slices by the Caporizzo Lab. They define (with precision) how targeting microtubules can improve cardiac function by facilitating relaxation and early diastolic filling.
8 Mar 2024
Excited about our latest work in @JMCCPlus showing colchicine improves diastolic performance in myocardial slices. Congrats @EmmaleighHancoc and thanks to Brad Palmer, @IonOptix , @UVMLarnerMed , and @uvmcvri for making this possible!
sciencedirect.com/science/ar…
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29 Feb 2024
Happy #RareDiseaseDay! Lucy, 5, #STXBP1, working HARD on that first word (Hiiiiiii!) and independent steps. Effortlessly bringing all the sunshine ☀️
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Ben Prosser retweeted
21 Feb 2024
Deadline alert! March 17th is the last day to submit your abstract for oral presentation consideration at the Gordon Research Conference on Cardiac Regulatory Mechanisms this June. Don't miss your chance to showcase your research! #CardiacScience #GRC #GRS
grc.org/cardiac-regulatory-m…
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Ben Prosser retweeted
20 Feb 2024
Rat cardiomyocyte stained with SiR-actin (magenta) & hoechst (cyan) imaged at high frame rate showing nucleus strain during contraction!
Don't miss your chance to read the amazing associated preprint "Microtubule forces drive nuclear damage in LMNA cardiomyopathy" from @Prosser_Lab, @LammerdingLab and @ShenoyLab featuring SPY555-tubulin and SPY650-DNA too!
Congratulations to the whole team!
doi.org/10.1101/2024.02.10.5…
18 Feb 2024
@AmiadDaria developed a novel assay to measure how cytoskeletal strain is transferred to the nucleus during the contraction and relaxation of the heart muscle cell. (🧵2/5)
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