We develop theoretical concepts and computational models - mechanobiology, matrix mechanics, nano- and energy- materials. Tweets by group members. @CEMB_STC
Joined June 2020
- Tweets 215
- Following 197
- Followers 1,050
- Likes 152
37 Photos and videos
24 Apr 2025
1/6 We built a sequencing-informed polymer model that integrates STORM, Hi-C, and RNA-seq to reveal how HC domains — especially their boundaries —regulate gene expression during drug treatment, microenvironmental changes, and cell fate transitions. doi.org/10.1038/s41467-025-5…
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24 Apr 2025
6/6 🤝 Huge thanks to @ShenoyLab, @Melike_Lak, and @rp_mccord for the collaboration, and @CEMB_STC, the NCI MetNet - @NCIDCB! This work highlights the power of interdisciplinary science.
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24 Apr 2025
#EpigeneticRegulation #ChromatinDynamics #GenomicsResearch#EpigeneticMemory #CellFateDecisions #ChromatinRemodeling#CellBiology #SystemsBiology#GenomeBiology #ChromatinOrganization
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26 May 2023
22 May 2023
A new joint theory/experiment paper led by @ZeGongGreg just appeared in Nature Communications! We show how wave-like dynamics of immune cell podosomes arise from the coupling between chemo-mechanical signaling and actin diffusion. @CEMB_STC @PennEngineers
nature.com/articles/s41467-0…
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16 Feb 2024
Great news: the next meeting of the Invadosome Consortium (9th in this series) will take place in Vancouver, Canada, Oct. 01-04, 2024
Organizers: Karla Williams and Michael Olson
Excellent science and beautiful nature, what´s not to like? ⚗️🌲
invadosome.com/
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11 Sep 2024
Incredible speaker lineup uncludes @KoleRoybal, @NF_Steinmetz, @KWhiteheadLab, @NatalieArtzi, @LindaGGriffith1, @ManishButte, @Tang_Lab_UCSF, @ValerieJHorsley , @BellasFATLab, @taabaman, @ShenoyLab, @DoloffLab, @SantiCorreaPhD, @JennyNJiang, @gail_l_rosen, @veiseho and many more!
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11 Sep 2024
Come one, come all, I want to see you here this Fall! Register for #IMES2024!
Trainees & early career investigators - submit your abstracts for a chance to win cash prizes and oral presentations! Travel Scholarships are available!🤑
Due: Oct. 1
Link: tinyurl.com/4swvjttr
🚨 Last Call: Abstract Submission Deadline Approaching! 🚨 #IMES2024 is the only conference dedicated to convergent research in translational immunology and engineering.
📅 Deadline: Oct. 1, 2024
Submit here: tinyurl.com/35uwzcj7
Learn more: tinyurl.com/IMES2024
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What balances the size of heterochromatic domains in our cells? @ShenoyLab et al explore the interplay of methylated histones, acetylation, and RNA polymerase II-driven supercoiling. Check out the sophisticated model led by Aayush Kant on @NatureComms nature.com/articles/s41467-0…
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Last day of the wonderful GRC on Signal Transduction by Engineered Extracellular Matrices #GRCSTEEM organized by Shelly Peyton and @kumarlabucb started with a session on multiscale modelling, with discussion leader Vivek Shenoy and first speaker @davidodde
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27 Jun 2024
Our findings reveal how chemo-mechanical environment cues such as changes in cell extracellular matrix stiffness affect not only the availability of epigenetic regulators but also the mechanosensitive binding of heterochromatin to the nuclear lamina.
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27 Jun 2024
New preprint on integrating biophysical computational modeling with high-resolution imaging to predict how epigenetics and chromatin-lamina interaction energetics regulate the size and shape of lamina-associated domains (LADs)! biorxiv.org/content/10.1101/…
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27 Jun 2024
We theoretically show that the size scale of LADs is dictated by epigenetic reaction rates. On the other hand, LADs could be either discrete bead-like shaped or elongated and spread-out along the nuclear lamina depending on the strength of chromatin-lamina interactions.
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