collectively ran by the Pruneda lab, MMI, Oregon Health & Science University @ohsummi | our views are our own

Joined September 2019
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Pruneda Lab retweeted
Great talk by Rachel Lacoursiere from @PrunedaLab regarding bacterial enzymes to understand non canonical ubiquitination #EMBOubiquitin24
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Pruneda Lab retweeted
Excited to share this work from former @PrunedaLab superstar @camgroberts! Cam tackled the challenge of identifying #ubiquitin regulators secreted by pathogenic bacteria, and found an entirely new type of E3 ligase that regulates P. aeruginosa virulence! biorxiv.org/content/10.1101/…
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Pruneda Lab retweeted
Fantastic to have @jnpruneda @PrunedaLab from @OHSUSOM visiting giving a seminar on his team’s exciting work on how pathogenic bacteria use nifty effector proteins to hijack the ubiquitin system and avoid the host response. Real pleasure to have you at @DTUbioengineer, Jonathan.
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As #RareDiseaseDay rapidly approaches, please consider contributing to our collaboration with @RaidenScience to study a rare pediatric disorder.
Our Annual Run4Raiden 5K is back! ⚡️🦓 This year's fundraising goal is to raise $60K to continue our UBA5 drug repurposing program. 🧬🔬 Sign Up or Donate Today: run4raiden.raiselysite.com @OHSUNews @jnpruneda @RuthJeanNapier
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Pruneda Lab retweeted
Please consider supporting @RaidenScience! We’re determined to find a way to help children afflicted with this rare #ubiquitin-related disease.
Our Annual Run4Raiden 5K is back! ⚡️🦓 This year's fundraising goal is to raise $60K to continue our UBA5 drug repurposing program. 🧬🔬 Sign Up or Donate Today: run4raiden.raiselysite.com @OHSUNews @jnpruneda @RuthJeanNapier
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Pruneda Lab retweeted
Pleased to share the final version of this work on UBA5, available at @eLife. doi.org/10.7554/eLife.89891.…

New @PrunedaLab research direction: a #RareDisease of the #ubiquitin-like modifier UFM1. This sets the stage for understanding and, one day, helping kids with UBA5 disease. Inspiring to work with @RuthJeanNapier and @RaidenScience on this important topic. doi.org/10.7554/eLife.89891.…
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Pruneda Lab retweeted
Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for this and many other achievements during his thesis work! sciencedirect.com/science/ar…

What can bacteria teach us about #ubiquitin? A lot! In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you! biorxiv.org/content/10.1101/…
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Great job @tylergfranklin!
Yesterday the @PrunedaLab produced its first PhD scientist! Congratulations @tylergfranklin on five years of incredible growth and science, capped by a fantastic thesis defense. Added bonus: his paper was accepted on the same day! Keep an eye on this one, he’ll do great things.
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Pruneda Lab retweeted
New preprint identifying shared and distinct mechanisms of inactivation of the #ubiquitin E1 enzyme #UBA1 across different diseases #VEXAS #SMA #lungcancer doi.org/10.1101/2023.10.10.5… Thanks to David Beck @nyulangone, @kyliejwalters and all contributors for a great collaboration!

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Pruneda Lab retweeted
Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/r…
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Pruneda Lab retweeted
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/r…
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Pruneda Lab retweeted
What can bacteria teach us about #ubiquitin? A lot! In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you! biorxiv.org/content/10.1101/…
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Pruneda Lab retweeted
Happy to share that this work is now online in its peer-reviewed form at @MolecularCell. Huge thanks to our peer reviewers for challenging us, and to my co-authors for rising to meet this challenge. Check out the final product! sciencedirect.com/science/ar…

I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. biorxiv.org/content/10.1101/…
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Great job Tyler!
Grad student 1st time presenter ⁦⁦@tylergfranklin⁩ impressed us all ⁦@FASEBorg⁩ Ub with cool Ub chain engineering; shown here with his PhD advisor ⁦@jnpruneda
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Congratulations @camgroberts!
Ever tried to give a 3-minute research presentation? It isn't easy! @PrunedaLab member @camgroberts gave a fantastic flash talk at #UKcellmicro2021 this week and even won a prize! Congratulations to Cam and thank you to the organizers for such a great meeting!
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Pruneda Lab retweeted
Ever tried to give a 3-minute research presentation? It isn't easy! @PrunedaLab member @camgroberts gave a fantastic flash talk at #UKcellmicro2021 this week and even won a prize! Congratulations to Cam and thank you to the organizers for such a great meeting!
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Of course Justine did a fantastic job, we were never DUBious! So proud of @justinevnguyen!
Huge congratulations to @PrunedaLab member @justinevnguyen for skillfully defending her Master’s thesis on bacterial deubiquitinases today! Well done Justine!
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