Professor at UT Southwestern Medical Center, Study hypoxia, oxygen sensing pathway and VHL pathway in cancers, including breast and kidney cancers.

Joined May 2009
93 Photos and videos
🙌Hey @utswcancer @UTSWMedCenter @UTSWCancerBio @UTSWHemeOnc @UTSWScience @UTSW_Pathology @UTSWMolBiol don't miss the next #KomenBreastCancerForum @jaehyukchoimd to present design of next genereation cell therapies @AriellaHanker @CarlosArteagaMD @hmcarthur 6/17 9am IN PERSON
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Qing Zhang retweeted
@KCRS26 is shaping up to be another fantastic meeting for the #kidneycancer community. Great science, great conversations, and great people! Hope to see many of you in Boston on July 23–24, or online if you can’t make the trip. #KCRS26 will bring together leaders in kidney cancer research, clinical care, advocacy, industry, and the patient community. In-person attendance is limited due to space constraints; however, virtual registration is free and open to all. Register: bit.ly/KCRS26Registration #KidneyCancer @kidneycan
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The SOCS3/JAK1/STAT3/HIF-2α axis represents a new novel regulatory pathway that integrates cytokine signaling with enhancer-mediated transcriptional control in clear cell renal cell carcinoma (ccRCC): doi.org/10.1172/JCI201639
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Offering new targets to overcome treatment resistance in kidney cancer: doi.org/10.1172/JCI201639 Jun Fang @JunFang_UTSW Qing Zhang @QingZhangLab & team @UTSWMedCenter discover that cytokine signaling drives kidney cancer by activating a genetic circuit that boosts HIF-2α expression. The figure shows SOCS3 induction by DOX suppressed tumor growth, as revealed by longitudinal bioluminescence imaging at week 0 and week 10. #ccRCC
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Qing Zhang retweeted
Our vision for the cardio-immunology program at UCSF! We will be hiring new post-doctoral fellows and physicians in this space. Stay tuned for more information! @UCSFCardiology @immunox
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Thrilled to share our latest publication on selected degradation of TBK1 in blocking tumor progression in RCC (as well as in PDAC). sciencedirect.com/science/ar…

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Led by @ChenghengLiao and collaborative efforts with Lindsey James @UNCPharmacy @UNC_Lineberger, supported by @NIH @CPRITTexas @AmerUrological @UTSW_Pathology @utswcancer
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Here is the free access link: authors.elsevier.com/a/1muqi…

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Editorial team from @CellChemBiol is great to work with and our special thanks to our reviewers making our paper better!
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JCI - Genome-wide CRISPR screen identifies a cytokine–enhancer circuit driving HIF-2α activation in renal cancer jci.org/articles/view/201639

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Glad to share our latest study on elucidating the HIF2a regulatory mechanism beyond the canonical VHL-HIF signaling. Our CRISPR screening identified SOCS3-JAK1-STAT signaling controlling HIF2a transcription.
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Big Thanks for collaborations from many colleagues @jeremy_m_simon @ChenghengLiao @JBrugarolas @Ram_Mani_PhD and many more. Funding supported by DoD, @CPRITTexas and @theNCI @UTSWMedCenter @UTSW_Pathology @utswcancer
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Qing Zhang retweeted
Mar 15
Elizabeth P. Henske, Qing Zhang, James Nathan, and David Mole (not pictured) discussed "Advances on Studying Oncogenes and Tumor Suppressors in Kidney Cancer" in a plenary session at the AACR Conference on Innovations in Kidney Cancer Research. #AACRkidney26 @QingZhangLab
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Qing Zhang retweeted
Mar 7
The X ecosystem is entering a new phase. Today, Platform X officially introduces X Wallet — a wallet designed as a core access point to the entire X infrastructure. Alongside this launch, we are opening the Xcoin presale, available exclusively through X Wallet. Access X Wallet and join the Xcoin presale here: xwallet.network What is X Wallet? X Wallet is more than a place to store digital assets. It is a functional gateway into the X ecosystem — built with a focus on security, usability, and scalability. With X Wallet, users can: - securely manage digital assets, - interact directly with Platform X services, - participate in ecosystem-level mechanics without intermediaries. X Wallet is designed to grow alongside the platform, unlocking additional features as the ecosystem expands.

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Qing Zhang retweeted
Publication alert📢 How do VHL- deficient ccRCC tumors fuel Mitochondrial metabolism under hypoxia? New in Cancer Res- ZNF395 emerges as a key link between HIF signaling and glutaminolysis, driving TCA cycle activity and tumor growth. Congrats to @QingZhangLab @UTSW_Pathology
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