Twitter account for the lab of Dr. Ashish Raj, a professor of Radiology at UCSF. Our research focuses on modeling brain networks in the context of human disease
Check out our recent blog on abnormal brain activity in Alzheimer's disease! Featuring work by Parul Verma, PhD and Ashish Raj, PhD!
radiology.ucsf.edu/blog/ucsf…
Come join us for our workshop on "Graph modeling of macroscopic brain functional activity dynamics" at CNS*2023 on July 19th, Leipzig, Germany
Workshop details can be found here: raj-lab-ucsf.github.io/cns20…@CNSorg
By concurrently estimating the joint eigenmodes and the functional eigenspectrum, we can reconstruct a given subject’s functional connectivity from their structural connectome. (3/4)
We perform elaborate experiments and demonstrate that the proposed algorithm for estimating functional connectivity from the structural connectome gives a competitive performance as compared to the existing benchmark methods with better interpretability. (4/4)
Check out our latest article nature.com/articles/s41598-0… describing Nexopathy in silico (Nexis), an extension of our previous NDM, which can quantify the effects of molecular nexopathy on the spread of tau. Here we quantify how microglia affect the diffusion and aggregation of tau.
If you're attending the #NiSALS meeting in Milan tomorrow, check out Ashish Raj's keynote lecture on Network-constrained techniques to characterize spread of pathology in neurodegenerative disease
Check out our recent review article in Translation Research, "Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis" - short 🧵to follow! (1/4) #Alzheimers#neurosciencesciencedirect.com/science/ar…
Check out our recent review article in Translation Research, "Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis" - short 🧵to follow! (1/4) #Alzheimers#neurosciencesciencedirect.com/science/ar…
However, the biology of #Alzheimers is very complex! The neuroimmune response, selective vulnerability, and AD-induced functional deficits (among other mechanisms!) all play a role in determining the propagation of protein-based pathology and ultimately neurodegeneration. (3/4)
We detail recent work towards the "next generation" of connectome-based biophysics models that take into account more of these key features, as well as propose ways in which these approaches can be augmented and integrated to obtain clinically impactful models! #ENDALZ (4/4)
Check out our latest review article on "Structure-function models of temporal, spatial, and spectral characteristics of non-invasive whole brain functional imaging" 🧠 (1/4)
frontiersin.org/articles/10.…
We present recent work on spectral graph theory based models that can accurately capture spectral as well as spatial patterns across multiple frequencies in MEG reconstructions. (4/4)