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Ravi Muddashetty Lab @RaviMLab

Neurons | Ribosomes | RNA

Joined May 2020
  • Tweets 104
  • Following 158
  • Followers 578
9 Photos and videos
🚨 Hiring Research Candidate 🧠 DBT-funded project on epitranscriptome regulation in neurons at CBR (IISc), Dr. Ravi Muddashetty lab. Molecular biology background neuroscience interest required (experience preferred). 📩 Apply: ravimshetty@cbr-iisc.ac.in ⏳ Deadline: 10-04-2026
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🚨 Exciting new publication alert! 🧠 Our lab uncovers how mGluR activation restores APOE4-induced deficits in neuronal protein synthesis and synaptic activity via the mTOR–pRPS6 pathway. Read more 👉 life-science-alliance.org/co… #Neuroscience #Alzheimers #SynapticPlasticity

Group 1 mGluR stimulation rescues APOE4-mediated translation defects in neurons

The E4 isoform of apolipoprotein (APOE4) is the most recognized risk factor for Alzheimer’s disease, implicated in early neurodegeneration and impaired synaptic plasticity. In neurons, exposure to...

life-science-alliance.org
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Ravi Muddashetty Lab retweeted
Longevity India@Longevity_IISc
21 Oct 2025
How does the brain shape how long and how well we live?🧠 Join our Webinar as we dive into Brain Aging & Longevity with leading neuroscientists and innovators! 📅 4th Nov 2025 |🕓 4:00 PM IST Register now & drop your questions for our panelists: shorturl.at/lTuQd
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Ravi Muddashetty Lab retweeted
Prof. Nikolai Slavov
@slavov_n
1 Oct 2025
A compelling illustration of the difference between mRNA abundance, ribosome density and protein abundance.
Prof. Nikolai Slavov
@slavov_n
26 Sep 2025
A cancer therapy targeting the interaction between metabolism & protein synthesis. Dietary restriction of arginine and proline depletes polyamines, which in turn causes ribosome stalling at codons with A in the third position. This shifts the balances towards cell ...
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In RNA Biology: FMRP regulates rRNA 2′O-methylation during neuronal differentiation. FMRP–snoRNA interactions shape ribosome epitranscriptomic states; loss of FMRP alters stepwise 2′O-Me dynamics, disrupting translation control in Fragile X Syndrome. doi.org/10.1080/15476286.202…

Altering rRNA 2’O-methylation pattern during neuronal differentiation is regulated by FMRP

The Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an autism ...

tandfonline.com
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Join our team at IISc! CBR-funded Postdoc position in dementia research using human iPSC models (Prof. Ravi Muddashetty). PhD in cell bio/neurosci stem cell & CRISPR experience wanted. Apply: CV 2 refs to ravimshetty@cbr-iisc.ac.in. Learn more: cbr-iisc.ac.in/ravi-muddashe…
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HIRING JRF! Join our team at CBR for a project on 'Mitochondrial translation dysregulation in Alzheimer’s Disease.' Send your CV and two references to ravimshetty@cbr-iisc.ac.in by August 8, 2025. #Alzheimers #JRFHiring #Mitochondria
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Ravi Muddashetty Lab retweeted
bioRxiv Neuroscience@biorxiv_neursci
7 Nov 2024
Transcriptome-wide mapping of small ribosomal subunits elucidates scanning mechanisms of translation initiation in the mammalian brain biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Ravi Muddashetty Lab retweeted
Poonam Thakur@poonam_thakur6
1 Aug 2024
The No Garland Neuroscience Meeting is back! Join us @tvmiiser from December 5-8, 2024. Follow @NGN_2024 for regular updates! 🧠 Register & submit your abstracts now. @AmruthaSwamina1 & I can't wait to welcome all #neuroscience enthusiasts to our campus. ngn2024.wixsite.com/iisertvm
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Ravi Muddashetty Lab retweeted
Palakodeti Lab@Palakodeti_Lab
30 Jul 2024
Delighted to share our latest preprint led by @MNinochkaDsouza and @Naveenkcg which reveals FMRP's role in regulating rRNA 2’O-methylation during neuronal differentiation, impacting ribosome function and protein synthesis. @DPalakodeti @RaviMLab biorxiv.org/content/10.1101/…

Altering rRNA 2’O-methylation pattern during neuronal differentiation is regulated by FMRP

The Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an Autism...

biorxiv.org
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Ravi Muddashetty Lab retweeted
Sangeeta Nath@NathSangeeta
24 Jul 2024
See our latest publication by @abinayar28 cell.com/iscience/fulltext/S… on how neurodegenerative stress facilitates toxic materials sharing with neighbours through membrane nanotubes. It is a product of great collaboration efforts. Thanks to @SivaramanLab @RaviManjithaya @RaviMLab.

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Excited to share our current findings published in @LSAjournal ! Congratulations to @R_Sarayu , Bindushree and Nisa. Well deserved!
LifeScienceAlliance@LSAjournal
16 May 2024
This work highlights the different calcium channels involved in controlling protein synthesis in neurons, and shows the dysfunction of this process in Alzheimer's disease neurons @CBR_IISc @RaviMLab @R_Sarayu bit.ly/3ylYfal
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Ravi Muddashetty Lab retweeted
LifeScienceAlliance@LSAjournal
16 May 2024
This work highlights the different calcium channels involved in controlling protein synthesis in neurons, and shows the dysfunction of this process in Alzheimer's disease neurons @CBR_IISc @RaviMLab @R_Sarayu bit.ly/3ylYfal
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Ravi Muddashetty Lab retweeted
James Clement
@jamesclementjnc
4 Jan 2024
A potential therapeutic target for ASD: downregulation of histone acetylation (could be a signature of SYNGAP1-related asd #autism #brain #drug #disease #therapy biorxiv.org/content/10.1101/…

Epigenetic Modulation to perturb the SYNGAP1 Intellectual Disability (ID) that ameliorates synaptic...

Sporadic heterozygous mutations in SYNGAP1 affects social and emotional behaviour that are often observed in intellectual disability (ID) and autism spectrum disorder (ASD). Although neurophysiolog...

biorxiv.org
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Ravi Muddashetty Lab retweeted
Shweta@shramdas
9 Oct 2023
Happy to host postdocs in our group--we work on genetics of Indian populations in the context of aging and neurodegeneration. Please reach out if interested!
RCB@unescorcb
27 Sep 2023
Call for applications under @DBTIndia Research Associateship Program (Call -I) are open for pursuing post-doctoral research in Biotechnology and Life Science at any university/ institutions across #India. For more information, please visit: rcb.res.in/DBTRA/ @unescorcb
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Ravi Muddashetty Lab retweeted
Minhaj Sirajuddin@ms_chirps
8 Sep 2023
New paper from @cytoskeletonlab Drisya Dileep @AmmuDris in collaboration with Tabish Syed, Kaleem Siddiqi @mcgillu @quorumetrix @Dhan_inStem embopress.org/doi/full/10.15… We combine tissue clearing, volumetric imaging & computer vision to obtain micron-scale heart myofiber organization

ALT @DBT_inStem @DBTIndia @India_Alliance

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Abinaya Chandrasekar@Abinaya113
1 Sep 2023
Happy to share our new article on the #CACNA1A variant from our group. authors.elsevier.com/sd/arti… #Freudegroup #epilepsy #CACNA1A #epilepsyeducation
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Ravi Muddashetty Lab retweeted
Abinaya Raghavan@abinayar28
26 Aug 2023
Curious to know more about cell-cell transfer through Tunneling nanotubes and their effect on alpha- synuclein induced toxicity? Check out the link in the thread @PhDVoice @AcademicChatter @OpenAcademics @ThePhDPlace @PhD_Genie #AcademicTwitter
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Centre for Brain Research, IISc@CBR_IISc
27 Jul 2023
We are delighted that our faculty member @BratatiKahali has been recommended for the IA Intermediate Fellowship, which will help harness the power of large-scale #genetic analyses to study the interplay between metabolic risk factors and cognition to gain insights into #dementia.
DBT/WT India Alliance@India_Alliance
27 Jul 2023
DBT/Wellcome Trust India Alliance is proud to announce its recently recommended Fellowship #Awardees for #EarlyCareer #Fellowship (2022-2023 round) #IntermediateFellowship, and #SeniorFellowship (June 2023 round) in #BasicBiomedicalResearch 🔗know more – lnkd.in/guFHD4YZ
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Centre for Brain Research, IISc@CBR_IISc
27 Jul 2023
We are proud to share that Dr Justin Joseph, a postdoc in the lab of @ChinnaAdaikkan, has been recommended for the @India_Alliance Early Career Fellowship. His project is aimed at developing & optimising a brain-computer interface to modulate neural activity in #Alzheimersdisease
DBT/WT India Alliance@India_Alliance
27 Jul 2023
DBT/Wellcome Trust India Alliance is proud to announce its recently recommended Fellowship #Awardees for #EarlyCareer #Fellowship (2022-2023 round) #IntermediateFellowship, and #SeniorFellowship (June 2023 round) in #BasicBiomedicalResearch 🔗know more – lnkd.in/guFHD4YZ
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