Razani lab @ Center for Immunometabolism cim.pitt.edu, U. of Pittsburgh studies macrophages, autophagy-lysosomes, nutrient signaling in metabolic disease
Joined January 2020
- Tweets 228
- Following 811
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29 Photos and videos
Thanks @JeffHsuMD. And thanks @ATVBCouncil Early Career Committee for having us. Great questions and looking forward to the new generation of leaders stepping up to research and care for patients with #CVD and #metabolism disease.
May 14
Early morning Early Career Training Session at #VascularDiscovery26
All-star panel of @ATVBCouncil faculty sharing their advice on cultivating leadership skills, time management, balance, mentorship/sponsorship & more
🔑 Leadership is hard work, specifically budget time for it
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Huge congratulations to @XiangyuZ0321 of @PittDeptofMed @PittVMI receiving his 1st #NIH R01 to study #macrophage #leucine manipulation as diagnostic & therapeutic strategy in #CVD #atherosclerosis. A force in @RazaniLab for years now becoming our alumni & starting Zhang Lab! 🤩🥳
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Fun times for @RazaniLab members with cameo appearance from Razani family to create 2 Marathon Relay Teams for the @PGHMarathon yesterday. Teams were appropriately called "#Lysosome Lightning" and "#FoamCell Fighters" 🤩. Guess which team won?
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A big thank you to @life_of_carlos for organizing it and to all the lab members who participated, some running a race for first time ever 💪 @AliiAjam @yushengyeh @Ziyang_LiuPhD @doureradjou @JunHuan70044527
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Proud of @yushengyeh of @RazaniLab & CIM for multi-achievements: A newly minted Instructor in @PittDeptofMed & recipient of @American_Heart Career Development Award & @PLRC_PittLiver P&F Grant 🎉🥳 Keep eye out for his exciting research on #Adipose tissue, #lipolysis, #obesity 💪
Mar 24
Double win! 🧬 Honored to receive the @American_Heart CDA and @PLRC_PittLiver PF Award.
These grants provide a critical foundation for my research as an Instructor at @PittMedicine. Huge thanks to the team and my mentors for making this possible!
#AHA #LiverResearch #Lipolysis
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Babak Razani, MD, PhD Laboratory retweeted
🔬 Join us at noon on Wednesday, March 11, for the next VMI/HVI Research Conference!
Dr. Babak Razani will present: "Release the Grease: Modern Insights into Lipolysis and Metabolic Dysfunction"
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New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their @atvbahajournals review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪
ahajournals.org/doi/10.1161/…
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7 Nov 2025
Proud of Terrific Trio @RazaniLab Postdocs make strong showing at #AHA25 NOLA this week:
@yushengyeh competes as finalist in #BCVS Katz Basic Science Research Prize. @Ziyang_LiuPhD presents #Galectin3 & @AliiAjam #cholesterol #mtor work at VB.MDP.15/16 & ATVB Council Reception 🔥
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6 Nov 2025
Nice showing by @RazaniLab members at the 16th Annual #Aging Institute Research Day for @AgingPitt @PittDeptofMed. @AliiAjam & @MdSaifurRKhan1 won Best Posters for Clinical/Translational Postdoc and Basic Science Faculty category 🔥💪 Will you guys be able to eat all that? 🤔
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17 Sep 2025
Super discovery by @LodhiLab in @Nature today. BCFA, which are #fattyacids derived from #BCAA like #leucine, are metabolized in #peroxisomes as new form of #brownfat #thermogenesis (heat production). Thanks for including us in this multi-year effort 💪
nature.com/articles/s41586-0…
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29 Aug 2025
Nice way to close summer 2025 for @RazaniLab and also celebrate our summer students from @PittVMI VUE Program and @PittDeptofMed @pitt_medicine Dean's Summer Research Program 🎉
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27 Aug 2025
Congrats Dr. Bahram Razani (@BahramRazani) on the official lab launch @UCSF @UCSFMedicine.
Looking forward to seeing Great things from the "other" Razani Lab! 😁
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25 Aug 2025
LIPA locus #SNP (#Lysosome Acid Lipase gene) long known as #CVD risk. Cool work by @FangLi47313348
of @hanrui_zhang lab in @ESC_Journals uses high-tech functional #genomics to uncover mechanism backed by mouse model. Thanks for including us in the journey. academic.oup.com/eurheartj/a…
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15 Aug 2025
Blocking #CD47 has emerged as promising therapy in #CVD. Check out work in @CircAHA by Zhen Guo of @Alicardsdoc lab identifying CD47 in #cardiomyopathy #heartfailure induced by doxorubicin & targeting it as novel therapy. Great partnering with you on this. ahajournals.org/doi/10.1161/…
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12 Aug 2025
Hunting for the next key metabolite besides #TMAO driving #atherosclerosis #CVD? Need to read excellent work by @SanchoLab in @Nature implicating gut #microbiota derived "ImP" with possible links to our favorite #macrophage #mtor signaling in the plaque.
nature.com/articles/s41586-0…
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24 Jun 2025
Check out our new commentary on #leucine and role in #CVD #atherosclerosis via #mtor #autophagy. Spearheaded by @XiangyuZ0321, @AliiAjam & @RazaniLab team we discuss next steps in limiting leucine's damage to the #macrophage & the atherosclerotic plaque.
tandfonline.com/doi/10.1080/…
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18 Jun 2025
News flash #trehalose aficionados: New work by @yushengyeh and @RazaniLab team shows this natural sugar inducing #autophagy #TFEB to treat #obesity #metabolism & other diseases is NOT effective by oral route and KO of gut enzyme #trehalase doesn't help.
frontiersin.org/journals/nut…
2 Jun 2025
New Research: Assessing the efficacy of the natural disaccharide trehalose in ameliorating diet-induced obesity and metabolic dysfunction frontiersin.org/articles/10.… #FrontiersIn #Nutrition
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18 Jun 2025
#trehalose is still a fascinating dissacharide that works brilliantly by parenteral (i.e. not oral) route to treat many diseases spanning #atherosclerosis, metabolic, & neurodegenerative diseases. It just cannot be ingested and assumed to be effective as suggested in many papers.
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18 Jun 2025
Our work suggests that if trehalose has disease-fighting effects by ingestion, they are likely secondary to other physiological effects and not directly.
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