Passionate about #immunology. Sensing damaged self, infections & microbiota by DCs and macrophages to ignite innate & adaptive immunity. #Immunometabolism
Joined September 2019
- Tweets 1,663
- Following 910
- Followers 3,323
- Likes 2,260
251 Photos and videos
Pinned Tweet
May 25
Does #mitochondrial #respiration in DCs just “fuel” activation?
In our new @SciImmunology study, we show that mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
science.org/doi/10.1126/scii…
@CNIC_CARDIO
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Siempre la recordaremos con su gran empuje, energía y alegría. Un fuerte abrazo a familia y amigos y a todo el @CNB_CSIC 🫂🫂🫂
✝️ Hoy ha fallecido la Dra. Ana Carrera tras una larga lucha contra su cáncer de pulmón. Una gran científica y persona. La echaremos de menos. Un abrazo a su familia y colegas de @CNB_CSIC. Que la tierra le sea leve. Nuestras condolencias desde el @ciccancer. @CSIC @ASEICAnews
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Jun 9
Wonderful list on the latest metabolism -related papers ellaborated by Cristina @apoptosislab!!! 👏🏻👏🏻👏🏻👏🏻
Cancer metabolism, inmunometabolism,
Mitochondria, metabolic stress, cancer cachexia, hypoxia and more
Metabolist May 2026
metabolist.wordpress.com/202…
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David Sancho retweeted
Cancer metabolism, inmunometabolism,
Mitochondria, metabolic stress, cancer cachexia, hypoxia and more
Metabolist May 2026
metabolist.wordpress.com/202…
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David Sancho retweeted
Jun 1
Papers like this are why science remains endlessly exciting. This one made me feel the same wonder I felt at 15 when I first discovered science. || Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions | Science science.org/doi/10.1126/scie…
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May 29
How does oxygen sensing shape alveolar #macrophage (AM) identity?
In our new @CellReports HIF-1α and HIF-2α play distinct, non-redundant roles in AM maturation & function
A #metabolic split that defines macrophage biology in the lung.
OPEN: sciencedirect.com/science/ar…
@CNIC_CARDIO
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May 29
🏡Take home:
Oxygen sensing splits macrophage identity:
👉 HIF-1α → glycolysis & immature state
👉 HIF-2α → lipid metabolism & surfactant clearance
Together, they define maturation, self-renewal, and function.
OPEN ACCESS: sciencedirect.com/science/ar…
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May 29
Led by @elenapriegosaiz @ireneab2 & Helena M. Izquierdo @CNIC_CARDIO
Thx to collb and funders:
@AgEInves @CienciaGob @ERC_Research @ComunidadMadrid @contracancerINV @ContraCancerEs @WorldwideCancer @criscancer @FundlaCaixa @CaixaResearch
OPEN ACCESS: sciencedirect.com/science/ar…
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David Sancho retweeted
May 29
✨🗞️ Las #mitocondrias controlan la activación de las células inmunitarias y la eficacia de la #inmunoterapia, según un estudio del @CNIC_CARDIO liderado por @SanchoLab lasexta.com/constantes-vital… via @constanteyvital | @laSextaTV
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David Sancho retweeted
May 28
HIF-1α and HIF-2α differentially regulate alveolar macrophage maturation and function @CellReports
cell.com/cell-reports/fullte… @SanchoLab
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David Sancho retweeted
Great talk at #EASCongress2026 on plaque regression in #atherosclerosis using spatial transcriptomics: regression shows a distinct lipid‑driven signature, with #Nestin⁺#macrophages and #Treg interaction via IGF1–IGF1R. Blocking this axis prevents regression!
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David Sancho retweeted
#GlutamineGlutamate ratio links to #macrophage metabolism, impaired #efferocytosis, and plaque progression. Very exciting to see how small metabolites are gaining increasing recognition in disease diagnosis and as alternative pathways in atherosclerosis. #ASCVD #EASCongress2026
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David Sancho retweeted
It is always a pleasure to hear @SanchoLab about cDC1 as key drivers of pathogenic Th1/CD8 T-cell responses, and a proof-of-concept strategy using nanoparticle-delivered dexamethasone to modulate cDC1–T cell crosstalk and reduce atherosclerosis. #EASCongress2026
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May 25
Does #mitochondrial #respiration in DCs just “fuel” activation?
In our new @SciImmunology study, we show that mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
science.org/doi/10.1126/scii…
@CNIC_CARDIO
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May 25
📌 Take-home: Mitochondrial complex I → redox control → antigen cross-presentation by DCs → CD8⁺ immunity
🚨FREE LINK (for 🚨2000 downloads, PLEASE only use if you have no institutional access):
science.org/eprint/MTXDH3X7H…
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May 25
Led by Sofía C. Khouili & @elenapriegosaiz & @Michel_Enamorad @CNIC_CARDIO & @IcahnMountSinai
Thx to @pgonzrodriguez & other collaborators & funders: @AgEInves @CienciaGob @ERC_Research @ComunidadMadrid @contracancerINV @WorldwideCancer @criscancer @FundlaCaixa @CaixaResearch
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