Professor of Medicine at Washington University| Studying lipid metabolism| Adipocyte Biology, BAT, Diabetes, NAFLD, Obesity, Peroxisomes| PhD UMICH
Joined January 2020
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Pinned Tweet
17 Sep 2025
Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
nature.com/articles/s41586-0…
@WashUDeptMed
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Irfan Lodhi retweeted
New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their @atvbahajournals review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪
ahajournals.org/doi/10.1161/…
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Excited to share our new publications working with @AlbertHKimMDPhD. We developed a stem cell model of glioblastoma (GBM) and uncovered how INSM1 programs a progenitor network that fuels GBM progression nature.com/articles/s41467-0…
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Irfan Lodhi retweeted
Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure | Science science.org/doi/10.1126/scie…
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Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH dlvr.it/TQJ9h0
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Irfan Lodhi retweeted
Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use? Our new study found that carnitine biosynthesis is crucial for fuel switching science.org/doi/10.1126/scie…
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Jan 8
Peroxisome-dependent ether lipid down regulation is also a prominent feature of ME/CFS patient lipid profiles. Our prior work and this new study call for a clinical trial of sodium phenylbutyrate that can boost peroxisome function on Long COVID 🙏🙏@NIAIDNews
Jan 7
I find it interesting that sodium phenylbutyrate was found in this study and even @Jie_Immunology's science.org/doi/10.1126/scie… to help reverse this in lungs and now gut?
Clinical trial soon?
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Jan 9
Excited to see this work published in Nature Metabolism! This study provides new insight into how normally stable adipocytes can be mobilized under extreme metabolic stress, independent of sympathetic signaling. Congrats to @schellerlab and the team!
Jan 9
Very happy to start 2026 by sharing our new manuscript in Nature Metabolism.✨ By studying the constitutive adipocytes in the bone marrow, we identified a brain-mediated pathway that bypasses the SNS to evoke massive fat loss. 🧠🦴
Full article here: lnkd.in/gH7eHv4r
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26 Nov 2025
Thank you @NIH for highlighting our recent @Nature paper! Extremely grateful for the support that made this work possible.
Unlike the white fat cells you may be familiar with, brown fat cells use energy to produce heat. NIH-supported researchers identified a previously unrecognized way these cells use energy. The findings suggest a potential way to promote weight loss by increasing heat generation in brown fat cells. bit.ly/3LSxeSK
ALT Infrared images of heat production from brown fat in a control mouse (left) and a mouse that lacks a protein called ACOX2 (right). Weisensee Lab
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6 Nov 2025
Shingo, thanks so much for highlighting our recent paper! Looking forward to exploring this further.
6 Nov 2025
Super interesting ! A new UCP1-independent thermogenic mechanism in peroxisomes sciencedirect.com/science/ar…
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Irfan Lodhi retweeted
7 Oct 2025
New content online: Novel UCP1-independent thermogenic mechanism identified bit.ly/47jtFvZ
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8 Oct 2025
Thrilled to share our work on adipose tissue heterogeneity out today in @emboreports! Huge congrats to first author Hoang Bui, Juli Hansen, and our special collaborator @valelosardo for guiding us through the mysterious world of single-cell analysis! embopress.org/doi/full/10.10…
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25 Sep 2025
A consensus guide to preclinical indirect calorimetry experiments go.nature.com/4nkLRvR
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20 Sep 2025
Happy to share new work led by outstanding former grad student Kubra Akkaya! Following up on our previous work, we show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell function and proliferation, shaping epithelial homeostasis and regeneration.
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18 Sep 2025
I remember watching @LodhiLab @WashUMedEndo present this stunning work on peroxisomal thermogenesis at WashU and thinking "That's a Nature paper!" Now it is:
nature.com/articles/s41586-0…
And I like these "Briefings" that let the authors discuss their findings:
nature.com/articles/d41586-0…
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2 Sep 2025
Out today in @CellReports! We found that coxsackievirus B3 (CVB3), which is associated with increased risk of #T1D, infects all human pancreas cell types, not just beta cells. Great collab with @hubert_tse KUMC. Led by @WashUdbbs PhD student @dveronese18 cell.com/cell-reports/fullte…
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Irfan Lodhi retweeted
28 Aug 2025
[please retweet] I’m #hiring! The Millman Lab is looking for a postdoctoral researcher to lead an exciting new project focused on vascularized #stemcell-derived islets for #diabetes disease modeling and cell replacement therapy. Email me your CV and cover letter.
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27 Aug 2025
Congrats Dr. Bahram Razani (@BahramRazani) on the official lab launch @UCSF @UCSFMedicine.
Looking forward to seeing Great things from the "other" Razani Lab! 😁
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15 Aug 2025
Blocking #CD47 has emerged as promising therapy in #CVD. Check out work in @CircAHA by Zhen Guo of @Alicardsdoc lab identifying CD47 in #cardiomyopathy #heartfailure induced by doxorubicin & targeting it as novel therapy. Great partnering with you on this. ahajournals.org/doi/10.1161/…
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Irfan Lodhi retweeted
10 Jul 2025
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science science.org/doi/10.1126/scie…
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