@Rego_Lab profile picture
Hesper Rego @Rego_Lab

Just a girl standing in front of a microscope asking it to take lots and lots of data. Torturing bacteria in the Rego Lab @YaleMed. she/her/hers

Joined March 2018
  • Tweets 129
  • Following 177
  • Followers 723
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Hesper Rego retweeted
Andy Goodman@Goodman_lab
10 Sep 2024
Faculty Search Webinar! Curious about the @YaleMicroPath faculty search and life in CT? Please join us for a Q&A webinar 9/19/24 12pm noon EST. Panelists @Rego_Lab, @HoLabHIV, @Goodman_lab, and Craig Roy. Participation is anonymous. Registration required: yale.zoom.us/webinar/registe…
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Hesper Rego retweeted
Andy Goodman@Goodman_lab
15 Aug 2024
Faculty search! @YaleMicroPath is looking to hire assistant professor(s) focused on the pathogenesis of viral, bacterial, parasitic, or fungal infections. Info: apply.interfolio.com/151755. Q&A webinar in Sept. Please RT!
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Hesper Rego retweeted
bioRxiv Microbiology@biorxiv_micrbio
30 Apr 2024
MmpL3, Wag31 and PlrA are involved in coordinating polar growth with peptidoglycan metabolism and nutrient availability biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Hesper Rego@Rego_Lab
12 Apr 2024
Another paper from the lab. The now Dr. Ng, @weilynnng , describes how the nucleoid associated protein, Lsr2, helps promote chromosomal mutagenesis in mycobacteria. journals.asm.org/doi/full/10…

A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting...

Unlike many other pathogens, Mycobacterium tuberculosis has limited ability for horizontal gene transfer, a major mechanism for developing antibiotic resistance. Thus, the mechanisms that facilitate...

journals.asm.org
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Really excited about this work from the lab. @celenagwin, together with @Kuldeep_R_Gupta, worked to understand how mycobacteria create heterogeneity in growth. biorxiv.org/content/10.1101/…

Spatial segregation and aging of metabolic processes underlie phenotypic heterogeneity in mycobac...

Individual cells within clonal populations of mycobacteria vary in size, growth rate, and antibiotic susceptibility. Heterogeneity is, in part, determined by LamA, a protein found exclusively in...

biorxiv.org
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This led to several surprising insights about the metabolism of mycobacteria at the single cell level. Specifically we show that the complexes that perform OXPHOS are spatially segregated from those that grow the bacterium. And metabolism changes as individual mycobacteria age.
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Lots of cool imaging went into this work (time-lapse 3D-SIM, biosensors, etc). It wouldn't have been possible without the efforts of Lin Shao @shaomumu who built our microscope, and made our analysis methods more robust and scalable.
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Hesper Rego retweeted
YaleMicroPath@YaleMicroPath
11 Sep 2023
Curious about the @YaleMicroPath faculty search? Please join on 9/18/23 at 12 noon EST for a Q&A webinar with @HoLabHIV @Rego_Lab @wmothes @Goodman_lab. Attendance and questions are anonymous. Details on department website. Register here: yale.zoom.us/webinar/registe…. Please RT!
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Hesper Rego@Rego_Lab
28 Apr 2023
Awesome opportunity to work with a great person!
Babak Javid@javid_lab
27 Apr 2023
Please RT! We are recruiting! Grant-funded positions to look at a) TB vaccine candidate development and b) TB antibiotic tolerance. Two SRA positions (links in next tweet). Ideal candidate will be curious, hard-working and fun to collaborate with. Full training provided.
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Really excited and proud of this work out of our lab. elifesciences.org/articles/8….

An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar...

Asymmetric growth in mycobacteria requires a protein that is involved in trafficking mycolic acids to the outer membrane.

elifesciences.org
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@Kuldeep_R_Gupta, working together with @celenagwin, discovered that a protein of unknown function in mycobacteria (PgfA) is recruited to one side of the cell by our favorite protein LamA, where it coordinates lipid trafficking and fast polar growth
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Studying a protein of unknown function is not for the faint of heart. We had many misdirections along the way, and there is still much to discover. Most importantly, we had loads of help from amazing collaborators: @ymoritalab, @JunLiuLab, and Ben Swarts' lab at CMU.
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Hesper Rego retweeted
Josh Dubnau 🇵🇸@joshdubnau
7 Mar 2022
1/9. There has been a ton of discussion on academic Twitter about reasons to leave academia. This thread is for young scientists who want to stay in academia. Let me first comment on the things I agree with from the “time to leave” tweets:
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Another manly start to Nobel week #dudesdudesdudes
3D-SIM microfluidics. Here we go!
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Hesper Rego retweeted
joanne flynn@joanneflynn19
25 Feb 2021
Interested in tuberculosis? We have postdoctoral positions available. We study immunology, vaccines and host-pathogen interactions. Great group of people! Great city! Email or DM me.
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Hesper Rego retweeted
Andy Goodman@Goodman_lab
27 Sep 2020
Yale Microbial Sciences Institute is proud to be a sponsor of #BlackInMicro week. Information at @BlackinMicro and online at blackinmicrobiology.org
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Hesper Rego retweeted
Andy Goodman@Goodman_lab
25 Sep 2020
Yale Microbial Sciences Institute - faculty position extended to all levels! Assistant Professor: apply.interfolio.com/78730. Associate or Full Professor: apply.interfolio.com/79085. Partnership with @YaleMed Physiology, @YaleGenetics, @YaleIBIO, and @YaleMicroPath. Please RT.
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Hesper Rego retweeted
Andy Goodman@Goodman_lab
21 Sep 2020
Assistant Professor search at the Yale Microbial Sciences Institute! More info here: apply.interfolio.com/78730. Women, persons with disabilities, and members of underrepresented minority groups: please apply. Assoc/full prof search coming soon. Please RT.
Tenure track assistant professor position at the intersection of microbiology, health, and disease

ALT Tenure track assistant professor position at the intersection of microbiology, health, and disease

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Hesper Rego@Rego_Lab
20 Jul 2020
My lab is hiring! We are looking for postdocs interested in studying host-pathogen interactions at the single-cell level with state-of-the-art imaging. Lots of cool tools available in the lab, including a home-built live-cell 3D-SIM. Please RT.
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Hesper Rego@Rego_Lab
21 Jul 2020
I'm not very active on the Twitter. But this worked better than I had ever hoped. Thank you all for helping to spread the word!
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