A terrific perspective from Ivan Dikic linkedin.com/feed/update/urn…)

We are thrilled to announce an opening for a tenure-track assistant professor in PCMM, Boston Children's Hospital and Harvard Immunology! Apply by August 2, 2026.

Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, @vaitsiankova, and Tomas Lama-Diaz! biorxiv.org/cgi/content/shor…

I am honored to receive a 2026 University Scholarly Achievement Award from KU. They say it takes a village. Mine took a village and then some: my lab, my trainees, my family. The award has my name on it, but it is theirs. They all make this job the best! youtu.be/o-KcgX3IiP8

Our review is now live @TrendsCellBio. We discuss how the DNA repair pathways c-NHEJ, MMEJ, and HR intersect at mammalian telomeres and the consequences for chromosomal instability. cell.com/trends/cell-biology…

Excited to share that the final version of our manuscript is now out @PLOSPathogens. Although apoptosis is considered immunologically silent, we find that activation of executioner CASP3 is critical for limiting intracellular bacterial replication! journals.plos.org/plospathog…

🎉 Huge congratulations to Dr. Carman Li on her Career Development Award @AACR 2026! A Basser core investigator, Dr. Li and her lab are transforming what we know about #BRCA1, #BRCA2 and hereditary cancer. So well deserved! @PennMedicine @penncancer @PennMDForum #aacr26

Identification of E3 ligase substrates & PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS) ft. Tanner Tessier, Joseph Dybas & Matthew Weitzman (@PennPathLabMed/ @CHOP_Research) @CommsBio nature.com/articles/s42003-0…

We’re proud to announce that Drs. Kiran Musunuru and Rebecca Ahrens‑Nicklas have been named to the @TIME list of the 100 Most Influential People in the World. Read about their lifesaving work developing a personalized gene-editing therapy: spr.ly/6014B6fzL6

Congratulations to Professor Klaus Kaestner @PennMedicine The @EASDnews 2026 Albert Renold Prize Awardee for outstanding achievements in the field of pathophysiology and treatment of diabetes easd.org/prizes/albert-renol…

Looking forward to the next PCGI Mini Symposium session on "Single Molecule Approaches to Genome Stability" on Monday, May 11, featuring Drs. Eric Greene (Columbia), Michelle Wang (Cornell), and Johannes Walter (Harvard) in the Gaulton Auditorium. med.upenn.edu/pcgi/upcoming-…

Yesterday, we enjoyed a wonderful round of talks by guests John Maciejowski, @J_Maciejowski, Sergei Mirkin (Tufts), with colleague Kavitha Sarma @sarma_lab, plus Piero Lamelza & Abby Hwang, at PCGI’s Mini Symposium on “Unusual DNA Structures." Our thanks to all who attended!

Great work in Mol Cell from John Maciejowski's group delineating BAF dependent regulation of TREX1 and cGAS in micronuclei. Very important implications for immune responses to chromosome instability. cell.com/molecular-cell/abst…

Excited to share our new paper in @CellCellPress with @MarcoRuella, led by @Shan_Liu_ and @PuneethGuru_. CAR T cell therapy loses effectiveness over time due to metabolic exhaustion, but we found a surprisingly simple approach to address it. 👇 cell.com/cell/abstract/S0092…

Congratulations to @kiranmusunuru (@PennGenetics/ @PennCardiology) & @AhrensNicklas (@CHOP_Research) on being named to the @TIME 100 List of the World’s Most Influential Leaders in Health! tinyurl.com/6w45skp2

New from @Nature: A team led by MSK breast medical oncologist Dr. Pedram Razavi found that tumors with germline #BRCA2 mutations or homologous recombination deficiency (HRD) are more likely to develop RB1 loss during treatment with CDK4/6 inhibitors, leading to therapeutic resistance. “If we look deeper and better understand the biology of tumors, we may be able to predict how they will behave on treatment,” says Dr. Razavi. “By forecasting how resistance develops, we can work to intervene earlier and potentially improve outcomes.” Learn more: bit.ly/4s0bx39

Be sure to check out the outstanding reviews in this DNA Repair Special Issue: Genome maintenance pathways in cancer - etiology, biomarkers and targets sciencedirect.com/science/ar… @BrownUCancer @BrownUniversity @BrownUnivHealth @Brown_SPH @EMGSUS @AshPrakash5

Our Science paper is out! 😀 Enjoy if you like SPRTN, DPCs, Innate immunity and Aging. science.org/doi/10.1126/scie…

Join us for the PARP meeting in CSHL. Registration deadline has just been extended to Jan 31st! Meet the academic and industrial leaders in Long Island this spring! meetings.cshl.edu/meetings.a…

There is still time to sign up for the GRC ! Join us in Sunny California for a week of DNA repair and cancer grc.org/dna-damage-mutation-…