@RomanSarott profile picture
Roman Sarott @RomanSarott

PI at Max Planck Institute for Medical Research | Chemically Induced Proximity | Gain-of-Function | Stanford Postdoc | PhD 2021 ETH Zürich

Joined October 2019
  • Tweets 155
  • Following 1,234
  • Followers 778
2 Photos and videos
Roman Sarott retweeted
Ingo Hartung@HartungIngo
Apr 20
Nathanael Gray @StanfordUChem about bifunctional proximity-inducing molecules which allow to rewire transcription #AACR26. TCIPs hijacking BCL6, BRD4, CDK9, p300 and p53 Y220C as “synthetic hybride TFs” leading to transcriptional hyperactivation & gain-of-function pharmacology.
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Roman Sarott retweeted
Dan Nomura
@DanNomura
24 Mar 2025
Cool paper from Crabtree and Gray labs: biorxiv.org/content/10.1101/…

A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death

Developing cancer therapies that induce robust death of the malignant cell is critical to prevent relapse. Highly effective strategies, such as immunotherapy, exemplify this observation. Here we...

biorxiv.org
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Roman Sarott retweeted
Max Planck School Matter to Life@mattertolife
14 Mar 2025
🚀 Great news! With support of the Dieter Schwarz Foundation, the #MaxPlanckSchools will keep growing. The funding boosts top-tier research & training—#ShapingTheFuture of science! Read more at bit.ly/3DQR9NZ @maxplanckpress @HRK_aktuell
An open palm with a launching rocket, surrounded by symbols such as light bulbs and gears

ALT An open palm with a launching rocket, surrounded by symbols such as light bulbs and gears
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Roman Sarott retweeted
William Gibson
@wgibson
22 Dec 2024
Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber! If you are a trainee interested in ambitious projects at the intersection of chemical biology and cancer biology, please reach out! gibsonlab.org
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Roman Sarott retweeted
Svetlana Tsogoeva@Tsogoeva_Group
18 Dec 2024
Explore the outstanding contributions by @francesarnold, @AlisonNarayanUM, @FlitschSabine, @HartwigGroup, @CarreiraGroup, @Shenvi_Lab, @hanzyduzit, @AdibekianG, @DrNitinAPatil, @RomanSarott, @ziyangnickqin, @LauraMBohnPhD1, @SHIONOGI_JP @ACSCentSci pubs.acs.org/doi/10.1021/acs…

Organic Synthesis and Catalysis Enable Facile Access to Bioactive Compounds and Drugs

pubs.acs.org
ACS Central Science@ACSCentSci
18 Dec 2024
Check out this new Collection from @ACSCentSci, showcasing the latest advances in organic synthesis and catalysis, highlighting innovative strategies for the construction of pharmaceutically relevant compounds, natural products, and drugs. Learn more: go.acs.org/bZm
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Can‘t wait to get started!🥳 Thank you @mpi_mr_hd for making my transition so smooth:)
Max Planck Institute for Medical Research@mpi_mr_hd
12 Dec 2024
🎊🎉Exciting news: @RomanSarott will join us in January as a new Research Group Leader and will establish the group “Chemically Induced Proximity”. We look forward to seeing you again in January, dear Roman! 🤩👏mr.mpg.de/14599628/chemicall…
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Roman Sarott retweeted
Max Planck Institute for Medical Research@mpi_mr_hd
12 Dec 2024
🎊🎉Exciting news: @RomanSarott will join us in January as a new Research Group Leader and will establish the group “Chemically Induced Proximity”. We look forward to seeing you again in January, dear Roman! 🤩👏mr.mpg.de/14599628/chemicall…

Chemically Induced Proximity

mr.mpg.de
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Roman Sarott retweeted
J. Am. Chem. Soc.@J_A_C_S
6 Nov 2024
Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from Multicomponent Combinatorial Library JACS @fischerlab1 @DanaFarber @harvardmed @Stanford @StanfordMed @StanfordCancer @RomanSarott #CRBN #Wee1 #MolecularGlue #Degraders #Multicomponent #Library pubs.acs.org/doi/10.1021/jac…

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial...

Small molecules promoting protein–protein interactions produce a range of therapeutic outcomes. Molecular glue degraders exemplify this concept due to their compact drug-like structures and ability...

pubs.acs.org
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Multicomponent reactions for molecular glue discovery, Congrats @HRazumkov and @ZzzxJiang ! Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library | Journal of the American Chemical Society pubs-acs-org.stanford.idm.oc…

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here with link that works for non-Stanforders... pubs.acs.org/doi/10.1021/jac…

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial...

Small molecules promoting protein–protein interactions produce a range of therapeutic outcomes. Molecular glue degraders exemplify this concept due to their compact drug-like structures and ability...

pubs.acs.org
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Roman Sarott retweeted
Uri Alon@UriAlonWeizmann
4 Nov 2024
Postdoc opportunity to work with Weizmann and Max Plank, superb funding. Enjoy the best of both worlds. weizmann.ac.il/sites/mpg-wis…

Max Planck-Weizmann Joint Postdoctoral Program

The Max Planck Society and the Weizmann Institute of Science announce a prestigious four-year postdoctoral program.

weizmann.ac.il
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Bivalent molecules unmute silenced genes nature.com/articles/d41573-0…

Bivalent molecules unmute silenced genes

Nature Reviews Drug Discovery - Discover the world’s best science and medicine | Nature.com

nature.com
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Roman Sarott retweeted
Radek Nowak@RPNowak
29 Oct 2024
We can now activate p53 Y220C by recruiting BRD4 to it with small molecule TRAP-1. This was a great collaboration with Gray lab and Attardi Lab @Stanford lead from @UniBonn @UniklinikBonn by @dpienkowska9 & @JanGerhartz. biorxiv.org/content/10.1101/…

Activating p53Y220C with a Mutant-Specific Small Molecule

TP53 is the most commonly mutated gene in cancer, but it remains recalcitrant to clinically meaningful therapeutic reactivation. We present here the discovery and characterization of a small molecule...

biorxiv.org
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Roman Sarott retweeted
Ryan Potts@pottslab
29 Oct 2024
New work from Nat Gray lab... Discovery of a small molecule chemical inducer of proximity that activates mutant p53 by linking to BRD4. Highlights how chemically induced proximity can be used to restore the functions of tumor suppressor proteins. biorxiv.org/content/10.1101/…

Activating p53Y220C with a Mutant-Specific Small Molecule

TP53 is the most commonly mutated gene in cancer, but it remains recalcitrant to clinically meaningful therapeutic reactivation. We present here the discovery and characterization of a small molecule...

biorxiv.org
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Fantastic feature story on our work on hijacking kinases to kill cancer cells - thank you @JuliaBauman2 for the highlight!
Julia Bauman
@JuliaBauman2
22 Oct 2024
Really nice new cancer drug modality: Chemical induction of proximity to hijack the activity of a cancer driver! From @RomanSarott @saigourisankar @baselakarim in the Gray & Crabtree labs @Stanford
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cen.acs.org/pharmaceuticals/…

Hijacking kinases to kill cancer

Bifunctional molecule links a cancer pathway to cell death

cen.acs.org
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If precision gene modulation with small molecules sounds fun - my starting lab @mpi_mr_hd is looking for postdoc candidates in molecular biology!
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Can we turn the activity of oncogenic kinases against cancer itself? In my postdoc work @Stanford, new in @sciencemagazine, we show exactly that. science.org/doi/10.1126/scie… #ScienceResearch #InducedProximity @Stanford_ChEMH @StanfordCancer @snsf_ch @StanfordMed

Relocalizing transcriptional kinases to activate apoptosis

Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit their catalytic...

science.org
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Leveraging chemically induced proximity, we convert kinase inhibitors into locus-specific activators of gene expression. In place of a tweetorial here a video that @saigourisankar and I got to do with @FNucleosome. youtu.be/-eNl-ByXB-E?si=VhY4…

Roman Sarott & Sai Gourisankar

Seminar byRoman Sarott & Sai Gourisankar entitled: Borrowing transc...

youtube.com
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I am deeply grateful for the fantastic group of scientists that I had the privilege of working with: Nathanael Gray, Gerald Crabtree, @GreenLymphoLab, @baselakarim, @NettlesSabin, @HinshawStephen, and all those not on twitter.
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