Hot off the presses! C-H activation by uranium oxo photocatalysis--now made site-selective by ligand control. Longer lifetimes. Higher activity. All possible with blue light.
In collaboration with the lab of @ProfArno.
Now in JACS: doi.org/10.1021/jacs.6c01402
Observed versus Predicted Reactivity, Selectivity, and Mechanism of Iridium Catalysts with Pyridyl Carbene Ligands for the Borylation of C–H Bonds | Journal of the American Chemical Society @UCBerkeley@HartwigGrouppubs.acs.org/doi/10.1021/jac…
Observed versus Predicted Reactivity, Selectivity, and Mechanism of Iridium Catalysts with Pyridyl Carbene Ligands for the Borylation of C–H Bonds (@J_A_C_S): pubs.acs.org/doi/10.1021/jac… (@HartwigGroup).
#AmBeedNewsletter ✨ Recently, the Hartwig Group (@HartwigGroup) reported an inexpensive, mild, and soluble base suitable for small & large scales with excellent functional group tolerance. This work has been published in @J_A_C_S.
💡Key Highlights
✅ New L147/K‑2‑EH system enables mild and efficient C–N coupling of diverse amines with aryl halides/nonaflates.
✅ Excellent tolerance for base-sensitive functional groups.
✅ Over 6,000 substrates analyzed; 28 nucleophile and 16 electrophile clusters mapped.
✅ QSRR models identify key structural features for reactivity.
The author mentioned in supporting information that some of the starting materials were purchased from AmBeed. We are honored to contribute to this groundbreaking research.
📚🔻 𝐑𝐞𝐚𝐝 𝐦𝐨𝐫𝐞 𝐰𝐢𝐭𝐡 𝐀𝐦𝐛𝐞𝐞𝐝
ambeed.com/newsdetail/JohnHa…#OrganicChemistry#PdCatalysis#MedicinalChemistry#DrugDiscovery#AmBeed#UTD#JACS
Excited to share our new method for Pd-catalyzed C–N cross-coupling, now published in @J_A_C_S !
This method utilizes an inexpensive, mild, and soluble base suitable for small & large scales with excellent functional group tolerance.
doi.org/10.1021/jacs.5c07790
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”