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Rothstein Lab @Rothstein_Lab

Dr. Jeffrey Rothstein is a professor of neurology and neuroscience @HopkinsMedicine and is the founding director of @packardcenter. (trainee run)

Joined April 2023
  • Tweets 2,552
  • Following 396
  • Followers 1,361
36 Photos and videos
Rothstein Lab retweeted
Suleyman Can Akerman@CanAkerman
Jun 11
Mitochondria directly interact with the nuclear pore complex nature.com/articles/s41586-0…

Mitochondria directly interact with the nuclear pore complex

Nature - Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

nature.com
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Rothstein Lab retweeted
Suleyman Can Akerman@CanAkerman
Jun 12
Excited to have shared our work on Nucleoporin210 in a tauopathy model at the Northeast Nuclear Envelope 2026 meeting at Yale (sites.google.com/view/nene20…). Thank you to the organizers for putting together such a nice program, and grateful for all the feedback and discussion!
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Rothstein Lab retweeted
Charlotte Fare@charlotte_fare
22h
TDP-43 self-assembly is regulated by its disordered NLS-region biorxiv.org/content/10.64898…

TDP-43 self-assembly is regulated by its disordered NLS-region

Cytosolic inclusions of the RNA-binding protein TDP-43 are a pathological hallmark of several neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia. Cellular...

biorxiv.org
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Downregulation of miRNAs Accompanies Increased HERV-K (HML-2) Expression in Amyotrophic Lateral Sclerosis link.springer.com/article/10…

Downregulation of miRNAs Accompanies Increased HERV-K (HML-2) Expression in Amyotrophic Lateral...

Molecular Neurobiology - Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease with limited treatments. Evidence suggests that reactivation of the HERV-K (HML-2)...

link.springer.com
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Development and characterization of 3D spinal cord organoids to advance the study of amyotrophic lateral sclerosis link.springer.com/article/10…

Development and characterization of 3D spinal cord organoids to advance the study of amyotrophic...

Molecular Biomedicine -

link.springer.com
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Two Patients With Juvenile-Onset, Rapidly Progressive Amyotrophic Lateral Sclerosis Associated With an SOD1 Variant (p.Asp125Gly) With Incomplete Penetrance onlinelibrary.wiley.com/doi/…

Two Patients With Juvenile‐Onset, Rapidly Progressive Amyotrophic Lateral Sclerosis Associated With...

Introduction/Aims Amyotrophic lateral sclerosis (ALS) patients are rarely encountered before age 25 years, often associated with genetic variants. SOD1 gene variants are well-known to account for a...

onlinelibrary.wiley.com
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The majority of axonal mitochondria in mammalian neurons lack mitochondrial DNA and do not produce ATP biorxiv.org/content/10.1101/…

The majority of axonal mitochondria in mammalian neurons lack mitochondrial DNA and do not produce...

In neurons of the mammalian central nervous system (CNS), axonal mitochondria are thought to be indispensable for supplying ATP during energy-consuming processes such as neurotransmitter release. We...

biorxiv.org
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A validated antibody toolbox for ALS research elifesciences.org/reviewed-p…
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Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis link.springer.com/article/10…

Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models...

Acta Neuropathologica Communications - Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal, early-onset neurodegenerative diseases. The most common genetic cause of FTD...

link.springer.com
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Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification biorxiv.org/content/10.64898…
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Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases cell.com/neuron/fulltext/S08…

Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions...

Ali et al. analyze over 5,700 cerebrospinal fluid and plasma samples across Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies, and frontotemporal dementia. They identify shared...

cell.com
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Cryptic Splicing in ALS: From Driving Disease Progression to Unlocking Novel Therapeutics annualreviews.org/content/jo…

Cryptic Splicing in ALS: From Driving Disease Progression to Unlocking Novel Therapeutics

TDP-43 is an RNA-binding protein that regulates multiple aspects of RNA processing, and its mislocalization from the nucleus to the cytoplasm is a defining feature of amyotrophic lateral sclerosis...

annualreviews.org
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Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq science.org/doi/abs/10.1126/…

Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq

An in vivo approach combining high-throughput screening with cell type–specific readouts could enable elucidation of genotype-phenotype relationships in complex tissues. We developed an in vivo...

science.org
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Rothstein Lab retweeted
ShorterLab@ShorterLab
Apr 23
Astrocytes connect specific brain regions through plastic networks: nature.com/articles/s41586-0…

Astrocytes connect specific brain regions through plastic networks

Nature - Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com
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Rothstein Lab retweeted
ShorterLab@ShorterLab
Apr 23
Rab27b: A Modulator of Lysosomal Function and Alpha-Synuclein Clearance in Parkinson's Disease jneurosci.org/content/46/16/…

Rab27b: A Modulator of Lysosomal Function and Alpha-Synuclein Clearance in Parkinson's Disease

Lysosomes are often referred to as the cell's recycling center, serving as the terminal degradative compartments of the endolysosomal and autophagic systems, through which cellular waste is broken...

jneurosci.org
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Rothstein Lab retweeted
Suleyman Can Akerman@CanAkerman
Apr 28
TMEM106B C-terminal fragments drive nucleocytoplasmic transport failure and TDP-43 mislocalization in the aging human brain biorxiv.org/content/10.64898…
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Aberrant SOD1 aggregates in skeletal muscle target fibers in amyotrophic lateral sclerosis link.springer.com/article/10…

Aberrant SOD1 aggregates in skeletal muscle target fibers in amyotrophic lateral sclerosis

Acta Neuropathologica -

link.springer.com
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Biochemical and Immunohistochemical Associations of TDP-43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer’s Disease onlinelibrary.wiley.com/doi/…

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and...

Objective Immunohistochemically (IHC) measured transactive response DNA-binding protein 43 (TDP-43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe...

onlinelibrary.wiley.com
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TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosis link.springer.com/article/10…

TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosis

Acta Neuropathologica - Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and cytoplasmic mislocalization of TDP-43....

link.springer.com
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Decoding neurodegeneration one cell at a time jci.org/articles/view/199841
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