Now online: Read the new
@TransplantJrnl for March 2023! Highlights include:
◼ Transplant with Sickle Cell Disease
◼ Eplets - Hope and Hype
◼ Fibrinogen and Bleeding in Liver Transplants
◼ Change in IVUS Predicts Heart Transplant Events
Read here:
bit.ly/TPAissue
ALT Transplantation March 2023 Volume 107 Number 3. On the cover: Can We Use Eplets (or Molecular) Mismatch Load Analysis to Improve Organ Allocation? The Hope and the Hype. Tambur et al. The difference between an eplet and an epitope: (A) 4 eplets (yellow) are depicted on the background of an HLA class I molecule (α chain—green, β2 microglobulin—light blue, peptide—pink); (B) a rough depiction of the antibody footprint/epitope, assuming each eplet is a “core” for an epitope, is represented by a circle of a different color (purple, orange, blue, and yellow). This schematic representation clearly demonstrates that the footprint of the antibody may include additional eplets, beyond the “core” eplet. It further demonstrates that there is an overlap between the area of these epitopes such that‚ if 1 antibody binds to its target, other antibodies will be blocked from accessing their cognate epitope and therefore will likely not bind... Transplantation 2023;107:605-615.