Everything about Swiss #MedChem and #ChemBio. Led by the Division of Medicinal Chemistry and Chemical Biology (#DMCCB) of the Swiss Chemical Society

Joined September 2015
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Using pyridazine-based inhibitors as a starting point, the research team leveraged their improved permeability and brain-penetrant properties to develop imaging agents for NLRP3 that could help measure both target expression and occupancy by a drug in the CNS.
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It’s hoped that the resulting agent, [18F]NP3-627,  could enable the clinical development of drugs acting on the NLRP3 inflammasome, lead to a better understanding of their target engagement and optimal dose, and help stratify patients and monitor disease progression.
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📯 Paper Altert 📯 In the Journal of Medicinal Chemistry, researchers from @Novartis describe the discovery, characterization, and optimization of a series of pyridazine-based NLRP3 inhibitors, including lead molecule NP3-253. 🧫💊 pubs.acs.org/doi/10.1021/acs…
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NP3-253 displayed good efficacy and tissue & brain penetrance. The study also elucidated the molecule’s mechanism as a  NLRP3 inhibitor.
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NP3-253 is expected to be a useful tool to further study NLRP3 inhibition, especially in the central nervous system (CNS) in neuroinflammatory conditions.
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SwissMedChemBio retweeted
15 Nov 2024
🏆 EFMC-YSN PhD Prize 2025 🏆 Applications are now open! The EFMC-Young Scientists Network recognizes excellence by awarding a European PhD student in medicinal chemistry or chemical biology 🔗 Apply here: buff.ly/3sykmYD ⏱️ Deadline: January 31, 2025
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SwissMedChemBio retweeted
🚨#JobAlert🚨 Join us in Geneva @unige_en! We have an open #postdoc position starting in 2025. If you are interested in studying chromatin regulation and working with brain organoids, apply now! #sciencejobs More info: unige.ch/medecine/gede/en/re…
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SwissMedChemBio retweeted
Just a few days left (Oct 9) to submit your abstract for OC! Check the list of confirmed speakers and register to not miss your chance to be part of #EFMCISCB25! @EuroMedChem @SCS_DMCCB @YoungSciNet
Don’t miss your chance to be part of the #EFMCISCB25!Submit your abstract for an Oral or a Poster Communication by October 9 and showcase your research to a focused audience of Chemical Biologists and Medicinal Chemists. efmc-iscb.org/
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SwissMedChemBio retweeted
🔥 We have two open full prof positions at our institute (LOC) at @ETH_DCHAB @ETH_en 1. Synthetic Organic Chemistry 2. (Bio)Analytical Chemistry Apply until Nov 15 and be our colleague! ethz.ch/en/the-eth-zurich/wo…

Come be our colleague 👇. Two positions (synthetic organic and (bio)analytical) open at our institute (LOC). Amazing students and staff, colleagues, facilities, location, and long-term funding perspectives. What are you waiting for? Apply today 😀. @ETH_DCHAB #chemjobs
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SwissMedChemBio retweeted
Don’t miss your chance to be part of the #EFMCISCB25!Submit your abstract for an Oral or a Poster Communication by October 9 and showcase your research to a focused audience of Chemical Biologists and Medicinal Chemists. efmc-iscb.org/
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🚨 Your Opinion Matters! 🚨 We’re gearing up for the Basel Symposium 2025, and we want YOU to help shape the event. 🗳️ Cast your vote now for the topic you’re most excited to explore on February 6, 2025 🌟 strawpoll.com/GJn4442Dqnz
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⏰ The registration deadline for the Peptide Therapeutics Forum 2024 is approaching (this Friday!) 💊🧫🧬 Please join us for a fantastic day of peptide science in Basel on August 22 & 23! ptf24.scg.ch/registration
‼️Last chance to register for the Peptide Therapeutics Forum 2024 🗓️Aug 22-23 @biozentrum University of Basel ptf24.scg.ch/registration #ptf24 #peptides #chemistry #scs #medchem #chembio #symposia #switzerland
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SwissMedChemBio retweeted
Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in @J_A_C_S! We used flow-SPPS to synthesize several sidechain- and backbone-modified precursor peptides and demonstrated their in vitro transformation. pubs.acs.org/doi/10.1021/jac… @UZH_Chemistry @Hartrampf_Lab
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SwissMedChemBio retweeted
14 May 2024
Would you like a data set of 40,000 reactions for evaluating your reactivity prediction models? We made it, so you don’t have to. 1/10
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SwissMedChemBio retweeted
📢Good news! The program for the @SNE_ChemBio retreat on June 3-4, 2024, is now available! Join us to dive into enlightening sessions, hear from esteemed speakers, and enjoy the breathtaking scenery of Champèry, Valais 🗓️Check out the agenda here 👉 bit.ly/44Gibkc
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SwissMedChemBio retweeted
📣 18th EFMC-YSN MedChemBioOnline | Registration is Open! 📅 June 11, 2024 | 16:30 - 18:30 CEST 💻 Virtual Event 🔗 medchembio.online #MedChemBioOnline #EFMCYSN #ChemicalBiology #MedicinalChemistry #EarlyCareerScientists #Webinar
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SwissMedChemBio retweeted
🌸 The May edition of MedChemBioWatch is now available! Stay informed about the latest activities of EFMC, upcoming events and so much more... 🔗 efmc.info/medchemwatch.php?l… #MedChemBioWatch #EFMC #MedChem #ChemBio
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