Coaching for purposeful action, emotional resilience, and psychedelic integration
Joined March 2015
- Tweets 13,472
- Following 1,328
- Followers 3,301
- Likes 107,815
2,643 Photos and videos
Pinned Tweet
holy shit I realized I just did the exact thing from one of my favorite Asimov short stories, "The Last Question"
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me and who
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"you americans! you're so good at encouraging interesting choices!" -- @coladaclan
😂
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Sarah McManus ⮕ Vibecamp Jun 18-21 ✨ retweeted
Jun 9
Are you going to VibeCamp? Are you excited to sing 🏴☠️SHANTIES at VIBECAMP🏴☠️?
We've updated our spotify playlist and songbook, so go freshen your memory to get bully singing workingman songs of the sea stage11.ai/ShantyDroppers/
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An important, serious project... and when I see the animation, my mind immediately goes to "crazy straw design world"
(xkcd #1095)
AI could help us cure cancer, design gene therapies, and fix genetic diseases. But AI is only as good as the data it learns from. AlphaFold only worked because we had decades of data on how proteins fold. For most of precision medicine's hardest problems, that foundational data doesn't exist yet.
One of the biggest gaps: we don't have a good map of the proteins on cell surfaces that control what gets into cells. Without that, neither scientists nor AI models can reliably figure out how to deliver a therapy to the right place in the body. Most drugs in development today cluster around a small set of known targets, not by design, but because the rest of the map is blank.
The @deliverome Project is building that map from scratch, as an open-science nonprofit. They're cataloging which surface proteins exist, how abundant they are across different tissue types, and which ones can actively carry cargo into cells. Everything will be released openly and continuously, in formats ready for researchers and AI models alike.
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Sarah McManus ⮕ Vibecamp Jun 18-21 ✨ retweeted
May 28
Are you going to vibecamp this year? Want to help out briefly and in the process hang out and vibe with almost everyone else who goes? Please volunteer for one or more 2 hour shifts in the Teahouse!
discord.com/channels/8715225…
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Retreat center in Healdsburg, CA for sale -- any @EdgeEsmeralda folks looking for something like that? @devonzuegel?
May 26
A friend of my wife is getting old and selling her retreat center in Sonoma County.
If you want your own retreat center...
cassiellebrandyfoot.com/
healdsburgluxuryliving.com/h…
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dammit google get your venomous snakes right
this is the first search result and the image is completely, dangerously wrong!
even weirder, it links to a FL Fish & Wildlife FB post that's accurate and doesn't include that image?? 😵💫
May 24
This is not an area of strength for me and I give all these shapes wide berth. Maybe the kid has correctly depicted a snake which is successfully resembling a venomous one
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This image is dangerously wrong!
Even the rhyme "red on black, poison lack; red on yellow, kill a fellow" is better
Better images:
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turns I had exactly enough leftover stickers to repurpose them for this year's volunteer swag! 😂
it's almost too good, though -- our regional burning man event has had some growing pains this year re: logistics, and I was kinda hoping it'd look a little jankier!
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USE! MENTION!
these are DIFFERENT!!!
graaaahhhhhhhhh
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Sarah McManus ⮕ Vibecamp Jun 18-21 ✨ retweeted
Sing to me, O Muse, of a man who uses many different forms of transport
What in the iliad or the Odyssey should we fight about today?
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nooooo I was distracted making breakfast while on a group call
and I accidentally made TWO BREAKFAST! 😭
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I can't eat fancy ramen AND breakfast burritos!!
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Sarah McManus ⮕ Vibecamp Jun 18-21 ✨ retweeted
May 21
Toru Miyazaki gave 11 cats with advanced kidney disease an experimental injection. 15 others didn’t get it. A year later, 9 of the 11 treated cats were alive. Only 3 of the 15 untreated cats survived. He just filed for approval, and the drug fixes a defect only cats have.
Most cats die from one thing: their kidneys fail. By age 10, 4 in 10 cats already have chronic kidney disease, and by age 15, the rate doubles to 8 in 10. Once diagnosed, a cat has about 2 years left.
The reason kidney disease hits cats so hard is a broken protein in their blood. All mammals carry a protein that helps the kidneys clean out waste. In humans and dogs, the protein floats freely and goes to work when the kidneys are in trouble. In cats, it stays stuck to another protein and can’t get loose. So the waste piles up, and the kidneys eventually give out.
Miyazaki originally found the protein in 1999, back when he was at the University of Tokyo. He figured out the cat-specific glitch in 2015. The paper he published in the Veterinary Journal in February laid out the trial. The injection is a working version of the missing protein. His company, the Institute for AIM Medicine, filed the approval paperwork with Japan’s Ministry of Agriculture on April 24, 2026. If the review clears, the drug goes on sale in spring 2027.
The 30-year lifespan figure in the tweet is Miyazaki’s own projection of what cats could reach without kidney disease. The trial only ran a year, and the average cat today lives 15. Most die from the same disease this injection treats.
The research almost died in 2020. After running out of funding during COVID, Miyazaki went public. Cat owners across Japan responded by sending in 300 million yen, around 2 million dollars total. He resigned from the University of Tokyo and worked on the drug full time. The treatment in front of regulators today exists because cat lovers refused to let the research die.
May 20
An injection that can double a cat’s lifespan to 30 years has been developed
Clinical trials have begun, with regulatory approval projected in 2027
Community note
The vaccine addresses kidney disease, the primary cause of death in elder cats. While this would increase the average lifespan of cats by an unknown amount, the claim that it "can double a cat's lifespan" is unverified.
u-tokyo.ac.jp/focus/en/featu… greycoatresearch.com/blogs/news/cat…
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An older man was tending his front garden, and I told him the flowers looked beautiful
He said, "Do you want one? A seedling, I mean!"
I improvised a pot (wet paper towel in orange peel) & planted it when I got home!
Jerusalem sage, Phlomis russeliana (or maybe P. fruticosa?)
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*sigh*
5meo Georg, who lives in self-liberating reflexively luminous dance of emptiness and form, expresses basic okayness through spontaneous congruent activity, & takes over 10,000 breakthrough 5meo doses, is an outlier, an indweller, adn is unfixated on being countable or not
May 17
ok but what if I take 10,000 breakthrough 5meo doses
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*gasp*
hyperparasitism, in human systems!
en.wikipedia.org/wiki/Hyperp…
May 13
Meet the “Squatter Hunter.”
His real name is Flash Shelton, and he’s gained national attention for an unconventional, and highly effective, method of dealing with squatters: he moves into the occupied homes himself and makes the squatters’ lives so miserable that they eventually leave.
It all started when squatters took over his mother’s house in Northern California. Tired of waiting for the slow legal eviction process, Shelton decided to move in and turn the tables. His strategy worked.
To protect himself legally, property owners sign a lease granting him the right to occupy the home. Once inside, he uses simple but relentless tactics, blasting music, taking over shared spaces, eating their food, and generally disrupting their daily comfort. He also wears tactical gear and carries non-lethal self-defense tools like pepper spray and a stun gun for protection.
Thanks to his bold approach, Shelton has successfully helped return multiple properties to their rightful owners.
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my first ever job was a summer science internship about hyperparasitism!
we were hiking around in the Great Smoky Mountains National Park, taking samples of chestnut blight (a fungus that attacks trees), hoping to isolate a virus that weakens the fungus
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