Studying the cellular substrates of drug addiction and relapse vulnerability. he/him

Joined November 2018
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LlamaParse by @llama_index is so fun. Turn complicated PDFs into clean Markdown you can plug into your workflows. Instant boost in coherence, outputs, and context space. The table image decoding is also so wild. No more PDFs as “images” let your LLM actually see your PDFs!!!
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Application to present at the Second Italian Glia Network Symposium is closing next week. Apply your abstract by Oct 10!!! Do not miss the opportunity to discuss your research in a young and informal community !!! italianglianetwork.com/event…

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24 Sep 2025
Online now: Dysfunction of cortical GABAergic projection neurons as a major hallmark in a model of neuropsychiatric syndrome dlvr.it/TNGVLl
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Awesome analyes led by Hayley Thorpe (from @JKhokharLab) on how to optimize social media initiatives in @npp_journal!
Our Special Projects/Social Media teams are constantly looking for ways to expand the reach of the science YOU choose to publish with us... so much so, that former NPP intern Hayley Thorpe ( @BriKChen) explored data-driven ways to improve our efforts👇 nature.com/articles/s41386-0…
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Review: A neural manifold view of the brain nature.com/articles/s41593-0…

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Really interesting papers, confirming and extending what many believed true for a while. The last 20 years gave us the illusion of super hyper specialization of brain regions thanks to opto/chemogenetics. Turns out we were just under a lamppost. We're in a "neo-Lashley" era. Brain functions are mostly spread out throughout the brain, not in one spot. If you’re not already looking elsewhere than under the lamppost, you should.
Two flagship papers from the International Brain Laboratory, now out in @Nature: 🧠 Brain-wide map of neural activity during complex behaviour → doi.org/10.1038/s41586-025-0… 🧠  Brain-wide representations of prior information in mouse decision-making → doi.org/10.1038/s41586-025-0…
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"Dopamine was associated with reward learning or sensitivity (SMD, 0.26), and reward vigor (SMD, 0.32). By contrast, serotonin was associated with punishment learning or sensitivity (SMD), and aversive pavlovian processes (within-participant studies only; SMD, 0.36)."
Systematic review and meta-analysis: Pharmacological manipulations of #dopamine and #serotonin distinctly affect reinforcement learning components in humans. ja.ma/45O71L6 @Harry_Costello
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And just like that #CannabinoidGRC2025 comes to an end! Big thank you to my co-chair @CeceHillard and all the attendees and speakers! Congrats to @mayoonthebrain and @ryanmcpickle on their selection as chairs for the 2029 meeting!
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📣 NEW: Breakthrough discovery of a genetic link to pain co-led by NDCN's Prof David Bennett and Prof Simon Newstead @BiochemOxford The results of the research, published in @Nature, could lead to a promising new target for the treatment of #chronicpain.
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27 Aug 2025
📈 New data from NIH-supported Monitoring the Future study at @UMich shows increases in nicotine pouch, cannabis, vaping, & psychedelic use among adults. Monitoring these trends is vital to set smart public health priorities. 🔗Read more: news.umich.edu/nicotine-pouc…
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19 Aug 2025
Online now: Microglia regulate neuronal activity via structural remodeling of astrocytes dlvr.it/TMZKf2
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Join us this Thursday for the last #AstrocyteCafe session of this edition!!! Looking forward to hearing the talks by @Avishek92 , @Holt_LewisRhys and Kerstin Lenk!😍😎 Register for our free mailing list or email us to get the link ;)
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🚨 First paper from the Bocchi lab out now in @NatureComms! We show that astrocytes in the cortex arise from not one, but two distinct progenitor lineages, each giving rise to specialized subtypes with distinct roles. Here the story📖 doi.org/10.1038/s41467-025-6… See 🧵below for more.
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Activity of CRF neurons in the BNST reduces anxiety-potentiated startle in female rats in an estrous phase-dependent manner biologicalpsychiatryjournal.…

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