However, while these antibodies were villains in COVID, they were associated with markedly increased anti-tumor efficacy of immunotherapy. Sure enough, when we modeled the effects of anti-IFN-I in mice, the preclinical effect was the same with increased tumor rejection.

Check out our lab's new perspective piece by @_BlueJay3 and @yiledai published today in @ScienceMagazine about the impact of #autoantibodies beyond autoimmunity. This is a big focus of our research @fredhutch! (1/5) science.org/doi/10.1126/scie…