Associate Professor, Dermatology, UCSF. part of HTAN. Melanoma, skin cancer, single-cell, DNA/RNA-seq, spatial transcriptomics, cancer, dermatology, pathology
Joined November 2017
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209 Photos and videos
Pinned Tweet
Apr 27
Excited to share that our paper, “Somatic mutations distinguish melanocyte subpopulations in human skin,” is now out in Nature Cell Biology.
Reposting the thread below ⬇️
13 Feb 2025
Happy to share the latest preprint from our lab, “Somatic mutations distinguish melanocyte subpopulations in human skin”. biorxiv.org/content/10.1101/… [1]
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Jun 8
I am worried this is a mirage, caused by the fact that only the top third of grants are discussed. It is hard to make it into the top third if a single reviewer gives your grant a 5
The two factors are clearer and understandable. As a result, scores are much more consistent now, than in the past. It is a rare occurrence to see spread of preliminary overall scores of 3 points or more between three reviewers (eg 2, 2, and 5). (6/10)
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Hunter Shain retweeted
Jun 4
Incredible to see our work out today in Cell: "Plasma signals of lung tumor promotion for molecular cancer prevention."
cell.com/cell/fulltext/S0092…
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Hunter Shain retweeted
May 29
Heading to #ASCO this week and really looking forward to the energy and the science.
On a personal note, I’m proud to share some work my team is presenting this year. I want to briefly highlight why I think these results matter.
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Hunter Shain retweeted
1/ Thrilled to share our new paper, out today in @ScienceMagazine! We built a pan-cancer spatial atlas of tertiary lymphoid structures (TLSs) and developed computation and AI frameworks to study TLS biology at scale.
science.org/doi/10.1126/scie…
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Hunter Shain retweeted
May 16
Marty Makary misunderstood something fundamental about the FDA
There is not, and never has been, a ‘deep state’ to shove aside
statnews.com/2026/05/16/mart…
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Hunter Shain retweeted
May 12
On Friday, I hosted a forum with the top 5 Democrats running for governor of California on how they'd fix the state's housing crisis. Some really interesting moments, including this one, from @katieporterca, on California Forever and master-planned communities.
Full forum on podcast apps/Youtube.
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Hunter Shain retweeted
May 11
Excited to share SapiensOntoCellMap! 🚀 An open-source tool for ontology-aware, hierarchical cell type annotation of scRNA-seq and spatial transcriptomics data.
Built at @UCSF to solve a major gap: moving beyond simple labels to true biological context. 🧵👇
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Excited to see this in print! Kudos to Haikuo, Bo, and the entire team including @MinaXu7 @yalepathology @zhou_jingtian @arcinstitute to explore this clinically relevant area of lymphoma transformation with truly innovative technology. @theNCI #HTAN
nature.com/articles/s41467-0…
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May 6
Now do San Francisco
May 6
Yeah it's 70% human capital, 15% the food (underrated not overrated), 8% the subway, 6% that NYC is actually really pretty and 1% the Knicks when they're winning.
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May 6
STmut can now operate on Atera data from @10xGenomics. Here is a breast cancer that was profiled on the Atera platform
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May 6
STmut can be downloaded here. github.com/limin321/stmut. Thanks to @liminchen15 for creating the software and continually updating it to handle higher resolution spatial transcriptomics, as they are rolled out. Thanks to Vignesh Arunachalam for generating the present figures.
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May 6
Original publication is here, though the software has been through many versions since the original manuscript was published. link.springer.com/article/10…
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Apr 27
This is directly related to the movement to share more data. I am a proponent of data sharing, but it creates risks for research participants that previously did not exist. Nowadays, I routinely have to get IRB approval to study discarded human tissues.
This, from a guest @stuartbuck1 substack post on institutional review boards, is really spot on
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Hunter Shain retweeted
13 Feb 2025
Happy to share the latest preprint from our lab, “Somatic mutations distinguish melanocyte subpopulations in human skin”. biorxiv.org/content/10.1101/… [1]
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Apr 27
Excited to share that our paper, “Somatic mutations distinguish melanocyte subpopulations in human skin,” is now out in Nature Cell Biology.
Reposting the thread below ⬇️
13 Feb 2025
Happy to share the latest preprint from our lab, “Somatic mutations distinguish melanocyte subpopulations in human skin”. biorxiv.org/content/10.1101/… [1]
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Apr 27
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Apr 23
1. A tiny California tribe, the Yocha Dehe Wintun Nation, just donated $2 MILLION to MAGA Inc, Trump's Super PAC.
I decided to find out why.
It's an illustration of exactly how business is done in Trump’s Washington.
Follow along for details.
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