@SimMat20 profile picture
Simon Mathis @SimMat20

PhD @Cambridge_Uni | AI in protein design & engineering | biotech & environmental applications | enzymes | geometric DL | prev. @ETH_physics

Joined April 2020
  • Tweets 241
  • Following 1,080
  • Followers 1,034
20 Photos and videos
Simon Mathis retweeted
Simon Kohl
@saakohl
Mar 23
Today we're launching Latent-Y: the world's first autonomous agent for drug design, lab-validated end to end. Give it a research goal. Latent-Y reasons, designs, iterates, and delivers lab-ready antibodies, autonomously or collaboratively, with the biological reasoning of a PhD protein design expert. Technical report: tinyurl.com/latent-y-techrep… Blog post: latentlabs.com/latent-y Apply for access: platform.latentlabs.com
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Simon Mathis retweeted
Kieran Didi@DidiKieran
Mar 19
Join us next Tuesday and ask questions/discuss research!
Machine Learning for Protein Engineering Seminar@ml4proteins
Mar 19
Next Tues (3/24) at 4PM ET, @DidiKieran and Danny Reisenbach will present "Proteina-Complexa: Scaling Atomistic Protein Binder Design with Generative Pretraining and Test-Time Compute" Papers: research.nvidia.com/labs/gen… Sign up on our website for zoom links!
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Simon Mathis retweeted
Kieran Didi@DidiKieran
Mar 17
📢 We’re launching Proteina-Complexa — and after the Jensen keynote mention, we definitely had to post this thread now ;) Atomistic binder design with generative pretraining test-time compute, plus large-scale wet-lab validation. Project page: research.nvidia.com/labs/gen… 🧵 1/n
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Simon Mathis retweeted
Simon Kohl
@saakohl
16 Dec 2025
Introducing Latent-X2 — AI-generated antibodies with drug-like developability and low immunogenicity in human panels, zero-shot. Technical report: tinyurl.com/latent-X2-report Blog: latentlabs.com/latent-x2 Apply for access: partnerships@latentlabs.com
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Simon Mathis@SimMat20
15 Dec 2025
Lots of gems in there - can highly recommend checking it out! Thank you for all the great work @chaitjo and for making it so accessible
Chaitanya K. Joshi
@chaitjo
15 Dec 2025
Excited to release the fully open-source code for gRNAde - our wet-lab validated, generative AI framework for 3D RNA inverse design 🚀⭐️ I pride myself on open-science & this is probably the most intense release I've done!
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Today at 11am I’ll present some of the exciting work in AI x Bio we’ve been up to at @Latent_Labs at the @RenPhilanthropy booth (Hall A/B, booth 1343 @NeurIPSConf - straight through the entrance at the back left). Come say hi!
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Many thanks also to the UK Sovereign AI Unit @SciTechgovuk for the invitation!
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Replying to @Latent_Labs @RenPhilanthropy @NeurIPSConf
If you can't make it at this time, we're at neurips for the next couple of days - reach out to me or any of our team if you're interested catching up over coffee. There'll also be an event on Saturday: x.com/saakohl/status/1996907… Looking forward to many interesting conversations 🙌

Simon Kohl
@saakohl
5 Dec 2025
We've had a whopping 500 sign-ups for our @NeurIPSConf mixer tomorrow, heavily waitlisted now! 🤩 Traveling to San Diego now and can't wait for the workshops and our mixer, electric AI fo Bio scene right now! Lots of the @Latent_Labs team are on-site already, let me know if you'd like to meet for a chat!
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Replying to @Latent_Labs @NeurIPSConf
Thank you @RenPhilanthropy & @charlieharris01 for hosting us!
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Simon Mathis retweeted
Rohith Krishna@r_krishna3
3 Dec 2025
Today, we report a method for design of active enzymes, RFdiffusion2, in @naturemethods. For the first time, we are able to design enzymes with native-range catalytic activity. We also are releasing our next frontier model, RFdiffusion3, code 👇
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Congratulations @chaitjo - so exciting!
Chaitanya K. Joshi
@chaitjo
3 Dec 2025
Introducing gRNAde: our own little "AlphaGo Moment" for RNA design! 🧬🚀 📝: tinyurl.com/gRNAde-paper Unlike proteins, RNA design has long relied on "wisdom of the crowd" (human experts) or the slow crawl of directed evolution — gRNAde changes that! 🧵👇
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Simon Mathis retweeted
Joey Bose
@bose_joey
4 Nov 2025
Come do a PhD with me 😀! Promise of fun science and great coffee ☕
Gilad@giladturok
4 Nov 2025
I like the way @joeybos lays out his vision for PhD supervision! Seems intense and rewarding.
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Simon Mathis retweeted
Charlie Harris@charlieharris01
14 Nov 2025
🚨New package alert! 🧬 Introducing Pocketeer: A lightweight, fast protein pocket finder in pure Python! I built this as a Pythonic version of fpocket because I wanted something that could easily calculate subpockets. > pip install pocketeer Link at end of the thread 🧵(1/7)
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Super cool - congratulations Magnus & Team!
Magnus Bauer@kinasekid
30 Sep 2025
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: biorxiv.org/content/10.1101/…
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Simon Mathis retweeted
Adam Broerman@adam_broerman
24 Sep 2025
We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.
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Simon Mathis retweeted
Rohith Krishna@r_krishna3
19 Sep 2025
We asked ourselves what could we do if we worked cooperatively as a team to create a single model that could design any biomolecular interactions. Yesterday, we reported details of RFdiffusion3, the next step towards building functional proteins straight from the computer.
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Simon Mathis retweeted
Jasper Butcher@butcher_jasper
19 Sep 2025
Very excited to share our paper "De novo Design of All-atom Biomolecular Interactions with RFdiffusion3", now on BioRXiv. biorxiv.org/content/10.1101/… 1/n
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Simon Mathis retweeted
Kieran Didi@DidiKieran
10 Sep 2025
La-Proteina open source now, excited to see what people build with it!
NVIDIA Healthcare
@NVIDIAHealth
10 Sep 2025
🧬La-Proteina🧬 The first generative model demonstrating accurate co-design of fully atomistic protein structures (sequence side-chains backbone) at scale, up to 800 residues, with state-of-the-art atomistic motif scaffolding performance - has just made its code open-source! Learn more 🧵
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Simon Mathis retweeted
Alex Tong@AlexanderTong7
3 Sep 2025
Thrilled to announce I'm starting as a Principal Investigator at #Aithyra in Vienna! We'll be developing generative models to understand cell biology and design proteins. I'm hiring PhDs, Postdocs, & Visiting Researchers! PhD applications by Sept 10: apply.cemm.at

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Simon Mathis retweeted
Jason Yang@jsunn_y
26 Aug 2025
Check out our new perspective "Illuminating the universe of enzyme catalysis in the era of artificial intelligence" now out in @CellSystemsCP ! We discuss a vision and path forward for genetically encoding almost all chemistry, powered by new AI tools: authors.elsevier.com/c/1lg4h…

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