The Sorek Lab
Joined January 2015
- Tweets 1,115
- Following 268
- Followers 8,704
- Likes 2,276
110 Photos and videos
Sorek Lab retweeted
Jan 22
What if we could turn the tumor’s deadliest tricks against it?
New @Cancer_Cell: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Led by @GalYagel, @D_Rimini & @MVLocquenghien (1/15)
cell.com/cancer-cell/abstrac…
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Sorek Lab retweeted
4 Dec 2025
Happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life
go.bsky.app/redirect?u=https…
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Sorek Lab retweeted
25 Aug 2025
📢 Preprint out!
Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function.
Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!
biorxiv.org/content/10.1101/…
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Sorek Lab retweeted
13 Jul 2025
📢Preprint out!
Excited to share my final work from the @Soreklab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
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Sorek Lab retweeted
15 May 2025
Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases
In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement
26 Jun 2024
What if we could universally recombine, insert, delete, or invert any two pieces of DNA?
In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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Sorek Lab retweeted
30 Apr 2025
Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork!
nature.com/articles/s41586-0…
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Sorek Lab retweeted
4 Feb 2025
🗓️Tomorrow! Ariel Cohen, VP Development Projects will present "The Challenges & Opportunities of the Development Pathway for Phage Therapy" 🦠at the Antimicrobial Chemotherapy Conference 2025, join virtually 14:35 CET!
Register👉 bsac.eventsair.com/antimicro…
#PhageTherapy #Antibiotics
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Sorek Lab retweeted
31 Jan 2025
Another cADPR isomer involved in bacterial immunity has been discovered. For me, N7 was the least expected position; I was sure it would be N3, but no... So, there are two more positions for cyclization that should be discovered: N3 and -NH2. More Thoeris systems are waiting! :)
Now published @ScienceMagazine: TIR signaling activates caspase-like immunity in bacteria
We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats @FrancoisRousset & @IlyaOsterman!
science.org/doi/10.1126/scie…
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Sorek Lab retweeted
31 Jan 2025
Congrats our very own @Sys_Immunology member PI @TanaWein for the impressive new paper @Nature together with @SorekLab- Shedding yet another piece of the (inflammasome-related) origins of immunology in bacteria!! Proud of you Tana and team!
nature.com/articles/s41586-0…
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Now published @ScienceMagazine: TIR signaling activates caspase-like immunity in bacteria
We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats @FrancoisRousset & @IlyaOsterman!
science.org/doi/10.1126/scie…
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Sorek Lab retweeted
30 Jan 2025
We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: biorxiv.org/content/10.1101/…
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Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems
Congrats @TanaWein! Thanks Kranzusch lab!
tinyurl.com/CA88DD
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Read more about our discovery in the thread by lead author @TanaWein 👇
x.com/TanaWein/status/188468…
29 Jan 2025
Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in @Nature 🥳 Thanks to all the people involved especially the Kranzusch lab and @SorekLab
nature.com/articles/s41586-0…
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Our paper out @CellCellPress: Structure-guided discovery of viral proteins that inhibit host immunity
Congrats @ErezTzvi, Azita Leavitt, @amitai_gil, our collaborators @ Kranzusch lab, and coauthors
A 🧵 1/10
cell.com/cell/abstract/S0092…
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Congrats to all coauthors and especially to talented Erez Yirmiya @ErezTzvi , who had the vision to use AF for immune modulation research already since 2021, when AF was just released for public use
Read Erez' thread for more details on our discoveries:
x.com/ErezTzvi/status/188245…
23 Jan 2025
I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now!
cell.com/cell/fulltext/S0092…
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