#ASCO26 This one is special. This is the hottest paper of 2026 and potentially in the history of pancreatic cancer. Let’s dive in. RASolute 302: Daraxonrasib vs investigator’s choice chemotherapy in previously treated metastatic pancreatic cancer Abstract LBA5 (soon!) Presentation: May 31, 2026, 3:21-3:33 PM CDT For decades, pancreatic cancer has been where good ideas go to die. We have optimized chemotherapy. We have sequenced chemotherapy. We have celebrated modest gains. But the central driver of PDAC has always been sitting there in plain sight: RAS. More than 90% of pancreatic cancers have oncogenic RAS mutations, and until recently, we had essentially nothing direct to do about it. Daraxonrasib is an oral RAS(ON) multiselective inhibitor targeting the active GTP-bound state of mutant and wild-type RAS. And in RASolute 302, it delivered. Quick hits: 📌 Phase 3 international randomized trial 500 patients with previously treated mPDAC Daraxonrasib vs investigator’s choice chemotherapy 🧬 RAS G12 population 91.8% of patients had RAS G12 mutations 📈 OS in RAS G12 population 13.2 vs 6.6 months HR 0.40 P<0.001 📈 OS in overall population 13.2 vs 6.7 months HR 0.40 P<0.001 📊 PFS in RAS G12 population 7.3 vs 3.5 months HR 0.45 P<0.001 📊 PFS in overall population 7.2 vs 3.6 months HR 0.49 P<0.001 🔥 12-month OS Overall population: 53.2% vs 17.3% ⚠️ Toxicity matters, but this was not just more efficacy for more toxicity Grade ≥3 AEs: 61.8% vs 69.6% TRAEs leading to discontinuation: 1.2% vs 11.2% This is the kind of survival curve we almost never get to see in pancreatic cancer. This validates RAS(ON) inhibition in the most RAS-addicted major cancer. It takes a target we have talked about for decades and turns it into a clinically meaningful survival benefit in a randomized phase 3 trial. The next questions come fast: 1L combinations, maintenance, perioperative disease, sequencing, resistance, toxicity management, and whether this becomes a new backbone. RAS is here, and it couldn’t have come sooner. nejm.org/doi/full/10.1056/NE… @TheGutonclab @UGrewalMD @TimothyJBrownMD @OncoAlert @Onco_Nexus @ASCO @NazliDizman @LauraAlderMD @DVAraujoMD @DrBarbiOnc @LauraEsfeller @FunchainMD @YGaritaonaindia @DrSAHaddad @jgong15 @iandresmeraz @SakditadMD @RamilaShilpakar @RohitBanwar @lungoncdoc

Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived #ASCO26

this should hurt to look at. this should make you feel sick. this is one of the worst tragedies in human history and you can see it from space.

LOHEN LOOKS TOO GOOD BRO

이 일러가 진짜 좋은게 점점 안으로 갈수록 경계하면서 자신을 감싸는게 ㄹㅇ 키프리임… 비밀을 알려준듯 싶다가도 절대 끝까지 알려주지않아

Fire Emblem Awakening is 14 years old! Awakening saved the series. If it didn't sell above 250,000 units, Nintendo was reportedly going to retire Fire Emblem. It ended up selling ~2m units. Every Fire Emblem since has sold at least 1m with Three Houses selling ~5m.

I cannot do graphics design to save my life but hear, hear! Skeb cms at VGen, last 8 slots priced at $50! I'll have to raise my prices after this because of economy things going SUPER downhill, BUT I will open more non-skeb options once the slots cleared out. RTs appreciated!

Bonsai #Δ帽子 #witchhatatelier

Being a doctor tops the list

【 Welcome to my memorial space. 】 ⚠️Cos spoiler / OMORl ⚠️ You have been living here as long as you can remember.

Fly, Pit, FLY! #KidIcarus

Medical horror level: 10/10. 🤯 Imagine dying not because you got cancer, but because your tapeworm did. ​A @NEJM case report documented a man whose Hymenolepis nana parasite developed malignant stem cells. These tapeworm cancer cells then metastasized into the human host's lungs and lymph nodes. ​It’s the first known case of a parasite "sharing" its cancer with a human. Medicine is officially stranger than fiction

RT @suri_701: #TGCF #天官赐福 화성

Happy Birthday, Wanderer! #GenshinImpact #Wanderer Curious where I've been staying? A place like Nod-Krai doesn't lack shelter. I've made do. Besides, no one here knows it's my birthday, which means no noisy surprises, no sudden crowds trying to celebrate. Honestly, it's ideal, isn't it? And now that you've shown up, I suppose I'll allow it.

grieving families should never have to worry about feeding guests who came to pay condolences.

today is OMORI's 5th anniversary.

My father once told me the secret to a happy marriage. “Stay out of the kitchen. Let her handle the holidays.” I was 19. He was in his recliner. My mother was cooking for 14 people. She’d been up since 5 AM. He’d been up since the football pregame. I didn’t think anything of it. That’s just how it was. Fast forward 20 years. I’m in the recliner. My wife is in the kitchen. She’s been up since 5 AM. I’ve been up since the pregame. My daughter walks by and I see her watching. Not the TV. Her mother. Then me. Then her mother again. That’s when it hit me: She’s taking notes. My father taught me that holidays were for men to rest and women to work. He didn’t say it. He showed it. Every Thanksgiving. Every Christmas. Every Easter. The recliner passed from him to me like an inheritance I never asked for. This morning I woke up at 4 AM. Not for content. For the turkey. My wife found me in the kitchen at 6. She didn’t say anything. She just stood there. Then she cried. Your kids are taking notes. Not on what you say. On where you sit. The recliner is an inheritance. Be the generation that stands up.