centromeres, we build 'em. chromosomes, we break 'em. repetitive DNA's not junk to us. we're basic researchers answering fundamental questions in human biology.
Creating Outstanding Opportunities for Postdoctoral Trainees (CO-OPT) in Genomic Technologies invites prospective postdoctoral fellows to visit @DukeU. Present your research, explore research opportunities in @DukeCAGT, & network with new colleagues! cagt.pratt.duke.edu/postdocs…
Just received NOA for renewal of our human centromere R01 grant. We are extremely grateful to @NIGMS, U.S. taxpayers, and study section reviewers for their support of our research. 🧬 🔬🥼
Centromeres have been difficult to analyze because they comprise highly repeated DNA. Long-read sequencing has made it possible to study their structure and evolution. Read more in this Perspective by Steven Henikoff @fredhutch@genomeresearchow.ly/FSKI30sg79G#T2T
🎉BIG NEWS! 🎉
We've FULLY SEQUENCED the HUMAN GENOME! 🧬
This breakthrough achievement could lead to HUGE advances in medicine and research. Thanks to UCSC's @khmiga & @genome_gov 's @aphillippy for leading the #T2T team through this monumental effort!
news.ucsc.edu/2022/03/t2t-ge…
A fully sequenced human genome was announced more than 20 years ago. @ScienceMagazine, @genomeresearch, and others report on the efforts of the Telomere-to-Telomere (#T2T) Consortium to complete a comprehensive human reference genome. ow.ly/9S5130sg7eK
"...it was a big revelation that it wasn’t just a bunch of genes strung out along the chromosome, that there were these big deserts in between genes." #SN100sciencenews.org/century/dna-…
Sad to hear of the passing of Haig Kazazian, a giant in the field of human genetics. After identifying a LINE1 insertion causing hemophilia, his lab trail-blazed 30 yrs of key discoveries on human transposons. An amazing career he narrated here:
annualreviews.org/doi/abs/10…
New in Science: Researchers introduce “Giraffe,” an open-source short-read mapping algorithm for human pangenomes that can map sequencing reads to thousands of human genomes at a speed similar to that of standard methods. fcld.ly/sqrlu0i
Apply now! Stanford Biochemistry is searching for new faculty at the Assistant or Associate level. Great environment, colleagues and support in a fabulous place! See here for details and apply apply.interfolio.com/91883. Please RT. @StanfordBiochem@StanfordMed
What happens when DNA-loop-extruding SMCs collide with one another in a living cell?
Our article on SMC complexes bypassing one another in vivo is out @NatureSMB, in
a wonderful collaboration with Xindan Wang, @leonidmirny, Warren Ren and @Xciencepig. rdcu.be/cpVDg
I'm excited to announce that the "Miga Lab" will officially have a home in the Biomolecular Engineering (BME) Department at UCSC this Fall & I am honored to join the UCSC Genomics Institute as an Associate Director. migalab.com. @UCSC_BSOE @ucscgenomics 1/4
Excited to finally share: Segmental duplications and their variation in a complete human genome! This is a product of an awesome collaboration in the T2T consortium and I am thrilled to be sharing the SD side of this story. doi.org/10.1101/2021.05.26.4…