Clinical Immunologist, studying how genetic or therapeutic loss of an immune checkpoint leads to disease.

Joined November 2015
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We show that vaccine protection and neutralising antibodies wane more rapidly in people with obesity. nature.com/articles/s41591-0… Huge collaborative effort from my lab in @MRC_TU with @Farooqi_Lab @DrAzizSheikh @LintermanLab supported by @UKCovidVaxHub
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It is a lovely study demonstrating something that affects many of us now.
Our analysis of cognitive changes during the Wildtype SARS-CoV-2 Human Challenge Study is now out. We observed subtle memory, executive and attentional performance decrements post-pre infection in mild cases. doi.org/10.1016/j.eclinm.202… @ImperialBrains @eClinicalMed @iamcognitron
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The mRNA therapeutic potential is huge: Combined COVID-flu vaccines are coming: Moderna jab clears major test nature.com/articles/d41586-0…

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James Thaventhiran retweeted
🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today @Nature Strand-resolved mutagenicity of DNA damage and repair nature.com/articles/s41586-0… Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]
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We should form an nr4a1 appreciation group?
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I hope lots of people will use it!
An antigen signaling fate-mapping mouse reveals that intratumoral antigen signals trap CD8 T cell clonal populations in tumors @SciImmunology @Thav_Lab science.org/doi/10.1126/scii…
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This just out. Really hard work from Munetomo and Ty. Summary to come. Intratumoral antigen signaling traps CD8 T cells to confine exhaustion to the tumor site | Science Immunology science.org/doi/10.1126/scii…
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Very impressive research studying the impact of obesity on immunity in a resource poor environment under difficult circumstances with a lot of determination! Really enjoyable day for me.
Many congratulations to our fab student Mohammad Ali @AliMdKochi for passing his DPhil viva today on impact of DM & obesity on COVID immunity in Bangladesh. Many thanks to examiners Helen McShane & James Thaventhiran @Thav_Lab. Ali is now off to postdoc for @PKlenermanLab
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James Thaventhiran retweeted
Many congratulations to our fab student Mohammad Ali @AliMdKochi for passing his DPhil viva today on impact of DM & obesity on COVID immunity in Bangladesh. Many thanks to examiners Helen McShane & James Thaventhiran @Thav_Lab. Ali is now off to postdoc for @PKlenermanLab
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A great time to be a clinical immunologist.
Replying to @britsocimm
@BSI_CIPN Steering Group: Dr Emma Callery @LancsHospitals#HealthcareScientist Representative Dr Leman Mutlu @LemMutlu#PatientGroup Liaison Dr James Thaventhiran @Thav_Lab – Conference Programme Lead 5/6 🧵
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James Thaventhiran retweeted
SEMINAR: The Immunity scales – how obesity weighs in on immunity, Dr James Thaventhiran @Thav_Lab @MRC_TU Tuesday 27th February, 1.30-2.30pm Details: babraham.ac.uk/news/category…
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Had an incredible experience collaborating on the "Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments" project. Truly groundbreaking work with an amazing team! isevjournals.onlinelibrary.w…

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James Thaventhiran retweeted
This study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes life-science-alliance.org/co…
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Our research in this report is important for patients with primary immunodeficiency.
Does COVID-19 vaccination affect gut microbiome? We find minimal, if any, impact, even under immunodeficiency. Results encourage vaccine acceptance esp. considering large microbiome shifts observed during infection 🙏🏽 brilliant lab members @Thav_Lab @MRC_TU @Cambridge_Uni
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James Thaventhiran retweeted
New 2-year postdoc position available in my lab @TheCrick to test novel therapies for #IBD and related diseases by targeting a master regulator of #macrophage-driven inflammation using antibody-drug conjugates and related tools. Apply here: crick.wd3.myworkdayjobs.com/… Pls retweet!

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👁️‍🗨️ Curious about Age-Associated B Cells? 🧐 Dive into the video to understand why they are VITAL in the world of vaccine research. 💉🔍 Unlock the secrets behind immune response and protection for ALL ages! #VaccineResearch #AgeAssociatedBCells #ScienceExplained #StayInformed
🔬Dr @Thav_Lab investigates ways of improving therapies for autoimmune diseases such as lupus to decrease the risk of immunodeficiency after treatment. He also looks at responses to the #COVID19 vaccine in immunodeficient patients. @Cambridge_Uni #Autoimmunedisease #Lupus
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James Thaventhiran retweeted
🔬Dr @Thav_Lab investigates ways of improving therapies for autoimmune diseases such as lupus to decrease the risk of immunodeficiency after treatment. He also looks at responses to the #COVID19 vaccine in immunodeficient patients. @Cambridge_Uni #Autoimmunedisease #Lupus
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