SPIKED: Stanford Placebo vs Intraop Ketamine Evaluated for Depression. We masked ketamine with surgical anesthesia in depressed patients. Full details now published, peer review pending. Huge antidepressant response in both groups. @TheresaLii 1st auth bit.ly/3LMAueK

おもしろい。夢の内容を制御する手がかりになりそう。

Nice findings on dreaming during anesthesia emergence, Boris. This approach could redefine how we understand consciousness during medical procedures. Did the study explore variations in dreaming experiences based on different anesthetics? Or look into the potential cognitive benefits post-surgery? Would love to see how this protocol evolves! For those intrigued by such biomedical insights, check out Sci-Quest, a one-stop platform for every biomedical question, with capabilities to generate comprehensive reviews: sciqst.com. #Medicine #Anesthesiology

Fascinating protocol! Looking forward to the full results — especially how this protocolized approach to anesthesia dreaming may inform how we understand consciousness, emergence, and altered states, including psychedelics.

🧠⚡️💊New @Nature publication ! Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy nature.com/articles/s41586-0… @PennMedicine

I am looking for someone to join @Psyched_Alpha to research and write about psychedelic drug development and roll-out with me. Do you know someone? Please let me know! jobs.psychedelicalpha.com/jo…

Directional elements: the preprints are out! Congratulations to our amazing team linked here: biorxiv.org/content/10.64898… biorxiv.org/content/10.64898… biorxiv.org/content/10.64898… We screened for principles governing global brain dynamics by developing a set of new methods: 1) conformal immersion microscopy for recording high-speed/high-resolution neural activity across dorsal cortex; 2) unbiased computational screening of brain-spanning activity for fast directionally-propagating spatiotemporal elements; and 3) novel genetically-encoded voltage sensing integrated with designed spectrally-compatible opsins (derived from our channelrhodopsin structure work) for systematic causal testing. This unbiased screening/testing approach (which we show is applicable either to voltage or calcium imaging) allowed discovery and functional validation of a surprisingly well-defined set of directional elements that generalized across cell types and frequencies. The ability to work over long timescales at high speeds and with broad scope, anchored in optogenetic causal testing, unveiled rich spatiotemporal structure that was remarkably tractable. From the perspective of natural brain function, the directional elements were found to be behaviorally relevant and robust to diverse perturbations; however, we also found specific conditions allowing elemental incidence and boundaries to be selectively modulated, which may provide translational as well as basic-science insight... I'm so grateful to all our collaborators, and honored to work with all the outstanding students, postdocs, and staff who worked together to develop and apply this approach...

Introduce yourself with 10 bands you’ve seen live: Pink Floyd Radiohead Spiritualized Fugazi Metallica Cibo Matto Pigface The Jesus Lizard P-Funk Rob Base

🧵 Targeting sleep to treat depression: New mechanistic insights from the TIRED Study Thrilled to share our first major paper in @npp_journal ! Led by Adam Krause, we examined how CBT-I improves depression in people with comorbid insomnia. 🔗 nature.com/articles/s41386-0… 1/n

A low dose of opioid-partial agonist buprenorphine sustained the anti-suicide effects of a single-ketamine dose in new one-month RCT. Small study, blind somewhat intact. But no, it's not a long-term replacement for ketamine. Read why: psych-partners.com/a-drug-th…

"When Off-Label Ketamine Meets Direct-to-Consumer Telehealth: Liability Risks and Ethical Responsibilities" psychiatryonline.org/doi/10.…

DREADDs in humans--update: 3 clinical trials using hM4Di in humans registered in China. 2 for epilepsy and 1 for Parkinson's Disease. In our original paper we stated: "...We suggest that at least one of these designer receptors, hM4D, will prove useful for neuronal silencing in vitro and in vivo.." It seems we were correct.

A few months ago, @ResearchHub contacted me about joining the team. I wasn’t really looking for work. This is what made me take a closer look 👇 The Endowments feature they just launched is unreal, for scientists *and* anyone who supports science (1/4)

New publication! 🧠 Excited to share our latest paper, for which I am co-first author. This randomized controlled trial provides the first evidence that #buprenorphine can prolong and augment #ketamine’s antisuicidal effects in depression. doi.org/10.1176/appi.ajp.202…