Our work on human urate transporter is out @cell_res. @YaxinDai single-handedly drove this project, which revealed the transport and drug mechanism of URAT1. We are grateful for the tremendous support from @StJudeStructBio nature.com/articles/s41422-0…

Investigators have uncovered the full activation mechanism of sweet taste receptors, proteins that detect sugar and sweeteners. Their findings could guide the design of better sugar substitutes. ow.ly/X3Sl50Wzuts

Membrane Transport subgroup @BiophysicalSoc is thrilled to announce the Chris Miller Award—honoring groundbreaking contributions to membrane transport—debuting at the BPS Meeting! Named for Chris Miller, a true pioneer & mentor. Awardees will lecture at our subgroup symposium.

As 2024 ends, we’re celebrating key discoveries by St. Jude scientists. In this #ResearchWrapUp, we’re highlighting advances in #MolecularBiology that connect basic science to better health.

Congrats!!! @TanjaMittag

Congrats! Scott @TheBlanchardLab

Human URAT1 transports urate and is a target for gout treatment. The Lee lab @stjuderesearch presents 10 cryoEM structures of URAT1 with urate, pyrazinoate, and 3 anti-gout drugs, providing mechanistic insights into urate recognition, transport cycle, and inhibition by drugs. Read the full article below: nature.com/articles/s41422-0… #Gout #CryoEM #Urate #MedicalResearch #DrugDiscovery #StructuralBiology #GoutTreatment

Is it substrate? In our preprint led by @BiaoQiu1, we comprehensively assess EAAT3 substrate recognition properties using DSF, SSM ephys, and cryoEM. The L-Cys bound structure suggests that sodium binding is the final step of gate closure. Read below! biorxiv.org/content/10.1101/…

Researchers uncovered ten unique structures of URAT1, providing a deeper understanding on the urate transport mechanism that may offer insights into kidney disease mutations and help guide therapeutic design for gout. Learn more: ow.ly/TKS950Tjxhb

Beautiful work from @TheCHLeeLab, just out in @cell_res #CryoEM structures of human URAT1 provide insights into urate recognition, transport mechanism, and MOA of anti-gout drugs. #OpenAccess nature.com/articles/s41422-0…

Transport mechanism and structural pharmacology of human urate transporter URAT1 | Cell Res doi.org/10.1038/s41422-024-0…

Recovering true FRET efficiencies from single-molecule FRET experiments requires triplet state mitigation: rdcu.be/dOv3q. Donor and acceptor fluorophores accumulate in triplet states with elevated illumination intensity, which can effect FRET efficiency if unmitigated.

Excited to share our Annual Reviews in Biophysics article on Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function. Many thanks to all authors for their diligence putting this summary overview together! pubmed.ncbi.nlm.nih.gov/3901…

Recovering true FRET efficiencies from smFRET investigations requires triplet state mitigation pubmed.ncbi.nlm.nih.gov/3887… Grateful for the rigorous and tireless efforts from all authors of this work. Thankful to the Editor and Referees for helping us refine the take home messages!

Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals dlvr.it/T7yTN0

Online Now: Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals dlvr.it/T7FMQW

It is great fun to collaborate with @mjafreeman, the leading expert in the field. @lu_fangfang and @HongtuZhao worked together to reveal the structures of the ADAM17 sheddase complex and showed how iRhom2 restrains ADAM17 protease activity. sciencedirect.com/science/ar…

@StJudeStructBio is building a world class facility, this atomic resolution Krios G4 (with Cold-FEG Falcon4 Selectris) is one of the best setups in the US! Come see what the future of Structural Biology looks like at St Jude!!! ♥️

Pidathala, S., Liao, S., Dai, Y. et al. Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Nature (2023). doi.org/10.1038/s41586-023-0…