Joined May 2019
8 Photos and videos
The Melton Lab retweeted
Looking forward to keynote talks from @HansClevers, @TheMeltonLab & @GVNlab @CellSymposia #CSStemCells22 #stemcells #LosAngeles #California @CedarsSinaiMed December 8โ€“10, 2022 Register here hubs.li/Q01rNvCk0
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G. Oliver @NU_Lymphatics (๐Ÿ‡บ๐Ÿ‡ธ@NUFeinbergMed), C. Blanpain @CedricBlanpain (๐Ÿ‡ง๐Ÿ‡ช@ULBruxelles) & D. Melton @TheMeltonLab (๐Ÿ‡บ๐Ÿ‡ธ@harvardstemcell) are the guest speakers in the #ISDB2021 session โ€œ๐—™๐—ฟ๐—ผ๐—บ ๐—ฑ๐—ฒ๐˜ƒ๐—ฒ๐—น๐—ผ๐—ฝ๐—บ๐—ฒ๐—ป๐˜ ๐˜๐—ผ ๐—ฑ๐—ถ๐˜€๐—ฒ๐—ฎ๐˜€๐—ฒโ€ Join us in ๐Ÿ‡ต๐Ÿ‡น๐Ÿ‘‰ ISDB2021.com/registration
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The Melton Lab retweeted
Using a CRISPR screen and single cell analyses we asked how do stem cell-derived islets (SC-islets) react to immunological pressure (allogeneic). Among the hits we identified CXCL10 depletion as a way to escape immune rejection of grafted #betacells. cell.com/stem-cell-reports/fโ€ฆ
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The Melton Lab retweeted
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The Melton Lab retweeted
Couldnโ€™t ask for a better closure for my postdoc era. Was so great to attend and present at #ISSCR2022! Met so many old and new friends/colleagues. Some of which you see only in meetings like these every few years. Hope to see you all next year in Boston #ISSCR2023 @ISSCR
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The Melton Lab retweeted
Tomorrow 6/16 at #ISSCR2022, excited to present 'Immunogenicity of stem-cell derived islets as defined be a whole-genome CRISPR screen'. In person or virtual. 1:45pm PDT/4:45pm EDT, at 'Stem Cell Bioengineering - enhancing cell function'.
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The Melton Lab retweeted
Happy to share a pre-print of some work from my time in the @TheMeltonLab. First and foremost, many thanks to all the co-authors involved!! Now, for a brief outline of the findings..
Secreted cytokines provide local immune tolerance for human stem cell-derived islets biorxiv.org/cgi/content/shorโ€ฆ #bioRxiv
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Check out our latest pre-print entitled โ€œWhole Genome CRISPR Screening of Stem Cell Derived Islets Reveals Gene Targets for Hypo-Immunogenicityโ€
Glad and excited to share our online pre-print of a paper submitted for peer review in @CellStemCell. We report a whole genome CRISPR screen and transcriptomic profiling of immune challenged stem cell derived islet cells. See thread below ssrn.com/abstract=4081520
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The Melton Lab retweeted
Iโ€™ve finally settled back home in Sydney, Australia with my family. Iโ€™d like to thank Doug and all my colleagues in the @TheMeltonLab for the wonderful years together. Hope to see you soon Down Under!
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The Melton Lab retweeted
This is just one of many good things that might happen when you listen to the Stem Cell Report. Hear more from Doug Melton @TheMeltonLab & @naleite at bit.ly/3rqVhea & read their recent paper, bit.ly/3EkcXxp. @harvardstemcell @VertexPharma @ISSCR @martinperaJAX
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The Melton Lab retweeted
13 Apr 2022
โฐ Don't miss the opportunity to hear groundbreaking research & to network with this impressive line-up of past #ISSCR presidents at the #ISSCR2022 Annual Meeting 15-18 June in San Francisco. Register by 11:59 EDT 13 April for the best rates ๐Ÿ‘‰ ow.ly/oLJM50IJcqW
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The Melton Lab retweeted
Probably the last time together with these outstanding people and outstanding mentor. Thank you @TheMeltonLab
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The Melton Lab retweeted
It was a pleasure to participate with @TheMeltonLab on the @stemcellreports podcast. Thank you for having me!
๐Ÿ‘ Our new podcast is out! Learn about the latest research & potential clinical approaches using #stemcell-based treatments for type 1 #diabetes. ๐ŸŽง ow.ly/Xe6m50IxJlU Read ๐Ÿ‘‰ bit.ly/3J1nCxI @martinperaJAX @TheMeltonLab @harvardstemcell @naleite @VertexPharma
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The Melton Lab retweeted
17 Mar 2022
๐Ÿ‘จโ€๐Ÿ”ฌHear abt Doug Melton's latest work developing #stemcell therapies for #diabetes @ our Jerusalem symposium. His pioneering work deriving insulin-producing beta islets cells from PSCs led to the 1st in-human clinical trial ow.ly/7FAe50Im00X @HSCRB @harvardstemcell @Harvard
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The Melton Lab retweeted
3 Mar 2022
๐Ÿ”ฌToday in @stemcellreports, research from @naleite, Douglas Melton & colleagues has identified new ways to enhance the SC-beta cell survivability through genetic manipulation of the cells. Read on ๐Ÿ‘‰ bit.ly/3CeeAeR. Image: The Foundry. @martinperaJAX @TheMeltonLab
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The Melton Lab retweeted
Diabetes cell therapies take evasive action - @ElieDolgin go.nature.com/3hn0P42
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The Melton Lab retweeted
โ€œThe promising results weโ€™ve seen with #stemcell-derived islet cells could deliver a life-changing therapy for people who suffer from the relentless life-long burden of #Type1diabetes," said Dr. Douglas Melton, co-director of @harvardstemcell Institute.
Sheikh Mohamed bin Zayed, Crown Prince of Abu Dhabi, provides grant to Harvard Stem Cell Institute for diabetes research thenationalnews.com/uae/scieโ€ฆ
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โ€œMeet the Scientist: Douglas Meltonโ€ on vimeo.com/442134935/9f56d698โ€ฆ special thanks to @JDRF and @TheMeltonLab team! @HSCRB

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The Melton Lab retweeted
Are your cells mature? Does it matter? In our latest @CellCellPress, we review Cell maturation: Hallmarks, triggers, and manipulation. We discuss a new framework, based on cell plasticity, to understand how cells become specialized.. @PennCDB @IRM_UPenn authors.elsevier.com/c/1eNDXโ€ฆ
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