Synthetic biologist engineering mitochondria, RNA and new gene editing systems. NHMRC Investigator and Professor @CurtinUni @CurtinMRI and @TheKids_AU
Joined November 2017
- Tweets 116
- Following 859
- Followers 1,023
- Likes 1,865
48 Photos and videos
Pinned Tweet
9 Jun 2025
The discovery of CRYAB as the binding partner of TANGO2 highlights the importance of intermediate filaments in metabolism and mitochondrial function and reveals the molecular basis of TANGO2 deficiency disorder (TDD)
nature.com/articles/s41467-0…
#metabolism
#mitochondria
@NatureComms
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Oliver Rackham retweeted
Sun, surf and scientific talks 😎
Centre Director Ian Paulsen and COO J-L Heylen joined CoESB researchers from our @uwanews and @CurtinUni nodes for their annual Theme 2 (Synthetic Organelles) Retreat on Rottnest Island in sunny WA 🌊☀️ @TheRackhamLab @FilipovskaLab @arc_gov_au
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Oliver Rackham retweeted
7 Jun 2025
It takes two to TANGO2!
TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder
Many thanks to our team, collaborators and reviewers.
rdcu.be/epI3p
#metabolism
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12 Feb 2025
Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia?
Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable
staff.curtin.edu.au/explore-…
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Oliver Rackham retweeted
28 Dec 2024
New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice!
academic.oup.com/nar/article…
#RNA
#mitochondria
#mtDNA
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28 Dec 2024
Destroyer turned protector - FASTKD4 uses it’s Vsr nuclease-like structure to protect the polyadenylated tail of the mitochondrial MT-ND3 mRNA
academic.oup.com/nar/article…
#RNA
#mitochondria
#mtDNA
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Oliver Rackham retweeted
22 Nov 2024
Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact.
biorxiv.org/content/10.1101/…
Muscle mito nanotunnels 1/3🧵
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19 Sep 2024
Better CRISPR base editors!
More efficient nicking of the unedited DNA strand improves the ability to edit hard to reach bases.
@ACSSynBio
pubs.acs.org/doi/10.1021/acs…
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9 Jul 2024
Organelles within mammalian cells are surprisingly interconnected, and lipids play a critical role
Check out: Interorganelle phospholipid communication, a house not so divided @Trends_Endo_Met to see more
cell.com/trends/endocrinolog…
#metabolism
#mitochondria
#lipids
#Golgi
#ER
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Oliver Rackham retweeted
Online Now: Interorganelle phospholipid communication, a house not so divided dlvr.it/T9GyHt #trends #endocrinology #metabolism
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16 Jun 2024
Illuminating mitochondrial translation through mouse models
@hmg_journal
academic.oup.com/hmg/article…
#mitochondria
#mtDNA
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Oliver Rackham retweeted
10 Jun 2024
Unique architectural features of mammalian mitochondrial protein synthesis dlvr.it/T854Mm
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Oliver Rackham retweeted
11 Jun 2024
Unique architectural features of mammalian mitochondrial protein synthesis
30-day free access to our new review at: authors.elsevier.com/a/1jE3u…
Thanks to all the authors for their insightful contributions and our editor for their kind invitation and guidance.
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12 Apr 2024
High-fidelity Cas9 variants that prevent off-target cleavage typically reduce on-target activity. Adding TurboCas9 mutations to these enzymes can improve activity while maintaining off-target fidelity. @CellRepMethods
cell.com/cell-reports-method…
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Oliver Rackham retweeted
11 Apr 2024
Mutational rescue of the activity of high-fidelity Cas9 enzymes dlvr.it/T5NxQL
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Oliver Rackham retweeted
12 Apr 2024
Are you tired of slow gene editing and scattershot targeting?
Well no more, here we introduce HyperDriveCas9.
An engineered Cas9 variant that is both hyperactive and hyper accurate.
doi.org/10.1016/j.crmeth.202…
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Oliver Rackham retweeted
2 Jan 2024
💫NEW: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiomics to show that ether-#lipid #metabolism regulates inter-organelle biogenesis and dynamics.
rdcu.be/duKqS
nature.com/articles/s41556-0…
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Oliver Rackham retweeted
21 Dec 2023
Quantitative volumetric analyses and morphological interactions supported by multi-omic profiling identify global organelle defects and mitochondrial dysfunction that can be rescued with ether lipids. nature.com/articles/s41556-0…
#FIBSEM #3D #mitochondria #organelles #lipids
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21 Dec 2023
Check out this elegant News and Views @NatureCellBio by Antentor Hinton Jr @phdgprotein86 and Andrea Marshall @DrDreNeuroWay, highlighting the importance of organelle interconnectivity:
nature.com/articles/s41556-0…
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21 Dec 2023
“I am a part of all that I have met” – Ulysses; Alfred Tennyson
CRISPR screening, volumetric EM and multi-omics reveal the highly connected nature of organelles.
Defects in peroxisomes, Golgi and the ER converge on mitochondria via the lipidome.
nature.com/articles/s41556-0…
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