Professor & Head of Section of Cell Biology and Functional Genomics @imperialcollege. Spatiotemporal regulation of signalling of metabolically relevant GPCRs.
Joined June 2009
- Tweets 540
- Following 7,485
- Followers 2,393
- Likes 4,271
40 Photos and videos
Amazing 2 days discussing the latest research at the @Soc_Endo Endocrine Metabolic GPCRs 2026 Meeting. Fantastic speakers from different angles: cell biology, physiology, drug discovery, etc. Icing on the cake was our very own PhD student Linda Wong winning the Best Poster Award!
1
6
366
Alejandra Tomás Catalá retweeted
Feb 9
Independent of weight loss, semaglutide (Ozempic) improves knee arthritis by cartilage restoration, in both the mouse model and a small randomized clinical trial
@Cell_Metabolism cell.com/cell-metabolism/ful…
46
246
1,401
627,057
Great opportunity to join us at Imperial - 20 Assistant Professor positions at the Faculty of Medicine have just been advertised. See below:
imperial.ac.uk/jobs/search-j…
4
6
674
I am delighted to report that our latest paper has now been published in Science Advances:
science.org/doi/10.1126/scia…
In this study, we generated and characterised a humanised GLP‑1R mouse model carrying the gain‑of‑function A316T variant using CRISPR/Cas9 knock‑in technology.
2
11
23
1,117
Here is a link to an article about our study on the website of our funder @DUK_research: diabetes.org.uk/about-us/new…
1
1
1
192
Thanks to all the coauthors, particularly Denise Wootten and Giuseppe Deganutti for the cryo-EM and MD simulations, and the first author, former PhD student Liliane El Eid
130
Alejandra Tomás Catalá retweeted
📢We are excited to announce the initial speaker line-up for our #MembraneContactSites conference
⭐️Join us in Mexico in November 2026 to hear directly from the leading researchers in the field
➡️See who’s speaking and reserve your spot here! bit.ly/4acr3RR
2
4
702
Alejandra Tomás Catalá retweeted
Signaling Architecture of the Glucagon-Like Peptide-1 Receptor
In this contribution to JCI’s Review Series on Clinical Innovation and Scientific Progress in #GLP-1 Medicine, Gregory O Austin & Alejandra Tomas @TomasLab_ICL @imperialcollege explore the spatiotemporal regulation of #GLP-1R signaling: doi.org/10.1172/JCI194752
19
59
3,498
Alejandra Tomás Catalá retweeted
Jan 15
🔬@ScienceMagazine A genetically encoded device for #transcriptome storage in mammalian cells | Science science.org/doi/10.1126/scie… @kevin921tw @insitubiology
1
5
50
4,054
Alejandra Tomás Catalá retweeted
Jan 15
Thrilled to share our newest method for transcriptome recording using TimeVault!
science.org/doi/10.1126/scie…
8
60
313
34,775
Alejandra Tomás Catalá retweeted
Jan 17
Now online! Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo dlvr.it/TQP8NQ
14
44
7,310
Alejandra Tomás Catalá retweeted
New Online! Heterogeneity, dynamics and organelle interactions of lipid droplets dlvr.it/TQMlT6
1
45
173
15,397
Thanks for including our work in this amazing JCI Series on GLP-1 jci.org/review_series/134
Can one optimize next generation GLP-1 medicines through deconstructing of GPCR signaling? @jclinicalinvest jci.org/articles/view/194752
2
9
828
Our review is now out in JCI, where we discuss current evidence for the existence of GLP-1R–cAMP–PKA signalosomes at different subcellular locations, and the complexity of the GLP-1R spatiotemporal signaling architecture:
jci.org/articles/view/194752
2
3
9
526
Extremely happy to be part of this amazing series jci.org/review_series/134
1
240