Twitter account of the Trono Lab @epflSV to share our science on #transposons #epigenetics #KZFPs #evolution and #SARSCoV2 Account run by lab members.
Joined December 2019
- Tweets 91
- Following 84
- Followers 940
- Likes 37
29 Photos and videos
Trono Lab retweeted
6 Nov 2025
Welcome to Day 3 of 'The mobile genome: genetic and physiological impacts of transposable elements' 🙌🏼 #EMBOMobileGenome
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
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Trono Lab retweeted
23 Jun 2025
Evolutionarily recent transcription factors partake in human cell cycle regulation @CellGenomics
cell.com/cell-genomics/fullt… @PulverCyril @Trono_Lab
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Trono Lab retweeted
17 Jun 2025
#ICYMI—the March 15 issue received the most votes in our cover contest!
Congrats to the authors of "A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation." brnw.ch/21wTt7A
@Trono_Lab @epflSV
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11 Mar 2025
New preprint from the lab! More to come soon. Please follow us also on Bluesky: bsky.app/profile/trono-lab.b…
10 Mar 2025
New preprint of my postdoc work! We found a novel group of zinc-finger proteins that rapidly evolved in a lineage-specific manner to repress regulatory activities of transposon-derived sequences through anchoring nucleosomes.
biorxiv.org/content/10.1101/…
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Trono Lab retweeted
28 Feb 2025
Next week on March 6th, we welcome @wayomayo as the latest guest in our Max Planck Seminar Series.
Wayo is @EMBO Postdoc in the @Trono_Lab, @EPFL_en and we look forward to an interesting talk in which he opens up the (human) genome and its treasure trove of strange features: TEs
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Trono Lab retweeted
21 Nov 2024
We start our afternoon session with @Trono_Lab talking about transposable elements, their polydactyl domesticators and the species-specificity of human biology #GSTransposons
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20 Nov 2024
PREPRINT OUT! Cell cycle regulation is not limited to conserved TFs. Select young TFs (29-105myo) 1) regulate cell cycle genes and 2) set the #ReplicationTiming of gene clusters. Brainchild of @ForeyRomain and @PulverCyril. doi.org/10.1101/2024.11.04.6…
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20 Nov 2024
To sum up, evolutionarily recent TFs (ZNF519: primate-specific, ZNF274: therian-specific) partake in human cell cycle regulation. Are our genomes addicted to regulatory tinkering? Is this adaptation? Difficult yet fascinating open questions… Do reach out for comments!
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20 Nov 2024
Shout out to @KarleneCimprich, @Speck_Lab, @PaseroLab, @YeaLih for insightful comments, notably during #EESReplication! Shout out to the @EPFL and @epflSV for the support!
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24 Oct 2024
Thrilled to share our findings on early aGVHD detection! Single-cell transcriptome analysis reveals atypical monocytes circulating before clinical onset. Huge thanks to Geneva Hospital’s onco-pediatric unit, CANSEARCH, and our lab. Proud of this teamwork! academic.oup.com/jleukbio/ar…
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Trono Lab retweeted
17 Oct 2024
Didier @Trono_Lab preaching 🦀 ZFPs! I’m a convert! Our genome encodes ~400 KZFPs. Most bind to a single or a few TE subfamilies. A crucial layer of control over the ocean of cis-regulatory elements dispersed by TEs throughout the genome. #cshlTE24
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