Dr. Stuart Turvey and the Turvey lab are commited to improving child health through research. Our research transforms lives. There is urgency to what we do!
Joined February 2017
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114 Photos and videos
Turvey lab retweeted
Jun 3
👩⚕️Are you an MD?
Maintain your medical certification by peer reviewing for CIHR!
Learn more: cihr-irsc.gc.ca/e/53995.html…
ALT Earn CPD credits with CIHR peer review
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Thanks for promoting our discovery @FranMartinezGr
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease #RareDisease #Genetics #morbidgene rupress.org/jhi/article/2/4/…
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Jun 2
So great to partner with @SateeshMad93871 on this new discovery!
Excited to share our new collaborative paper establishing biallelic OSMR deficiency as a novel primary atopic disorder!
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/4/…
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Turvey lab retweeted
Excited to share our new collaborative paper establishing biallelic OSMR deficiency as a novel primary atopic disorder!
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/4/…
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Turvey lab retweeted
May 28
هكذا يتراكم العلم؛ ملاحظة تقود لاكتشاف، واكتشاف يفتح بابا لفهم أعمق. قبل سنة تقريبًا، وصفنا جين ال OSM كسبب جديد لفشل نخاع العظم، واليوم دراسة جديدة توضح أن نقص المستقبل المرتبط فيه OSMR deficiency يسبب أمراض حساسية شديدة ومبكرة. المثير للاهتمام أن الدراسة تلمّح لفكرة مهمة,غياب الجين نفسه يؤثر على تكوّن ووظيفة نخاع العظم، بينما غياب المستقبل يعطّل إشارات مناعية والتهابية مرتبطة بالجلد والحساسية. هذا مثال جميل على كيف أن نفس المسار الحيوي ممكن يرتبط بأمراض مختلفة تمامًا حسب موقع الخلل فيه.
23 May 2025
تم التعرف على جين جديد يُسمى OSM مرتبط بحالات فشل نخاع العظم الوراثي، وذلك من خلال عمل بحثي شاركت فيه مع فريق علمي، ونُشر في مجلة
The Journal of Clinical Investigation
هذا العمل بدأ كحالة تحليل سلبي للاكزوم ، لكن من خلال إعادة قراءة التحليل الدقيقة، تمكنا من اكتشاف طفرة تؤدي الى فقدان وظيفة جين ال OSM في عائلتين غير مرتبطتين.
تُظهر النتائج أن الطفرات في هذا الجين قد تؤثر على تكوين خلايا الدم، كما أظهرت الدراسة استجابة إيجابية للعلاج بدواء إلتْرومبوباغ/eltrombopag، مما يشير إلى إمكانية استخدامه كخيار بديل عن زراعة نخاع العظم في بعض الحالات.
هذا الاكتشاف يعزز فهمنا لدور جين OSM في أمراض الدم الوراثية، ويفتح آفاقاً جديدة للتشخيص والعلاج. فخور بهذا الإنجاز العلمي الذي انتقل من الملاحظة إلى النشر.
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Turvey lab retweeted
A new human inborn error of immunity: OSMR deficiency can underlie the HIES
Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome rupress.org/jhi/article/2/3/…
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Turvey lab retweeted
May 29
A surprising and exciting observation !
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/4/…
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Jun 2
👍👍I agree @Info4PI! For patients with inborn errors of immunity, genetic counseling helps families make sense of a genetic diagnosis while also advancing the knowledge that leads to better diagnoses, treatments, and outcomes for future patients.
🧬 Genetic counseling is a process that helps individuals and families understand the likelihood of a genetic condition and what that risk may mean for them.
For families affected by #PrimaryImmunodeficiency, genetic counseling can provide clarity, guide decisions about genetic testing, and support earlier diagnosis and treatment.
Understanding your family history isn’t just information - it can be lifesaving. 💙
#GeneticCounseling #PrimaryImmunodeficiency #GeneticTesting #PIAwareness
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May 29
New human inborn error of immunity!
By identifying biallelic OSMR deficiency as a novel Primary Atopic Disorder, we uncover a previously unrecognized mechanism driving severe allergic disease and provide new insights into the biology of human atopy.
New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50
#Immunology #Genetics #Atopy #IEIs
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Turvey lab retweeted
New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50
#Immunology #Genetics #Atopy #IEIs
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May 27
Check out our new Editorial comment: Italian pediatric experts consensus statement on diagnosis and management of primary atopic disorders' - Vaseghi‐Shanjani - 2026 - Pediatric Allergy and Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/…
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Turvey lab retweeted
Instead of studying asthma only after children get sick, Dr. Stuart Turvey and his team at @UBC have taken a different approach.
💩 By analyzing infant stool samples, researchers found differences in gut bacteria that were associated with later development of #asthma: bit.ly/4rqPbHa
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Turvey lab retweeted
Monogenic disorders of the IRF transcription factors. Review by Mattison Stojcic, Pariya Yousefi, Catherine Biggs, and Stuart Turvey: hubs.la/Q046V_810
📘 In our #InnateImmunity collection: hubs.la/Q046VVBm0
#KSInnateImmune26
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Turvey lab retweeted
New CHILD research in @CellReports by Darlene Dai, Charisse Petersen, @TurveyLab et al. suggests #breastfeeding 🤱may reduce socioeconomic-based differences in children’s chronic disease risk by influencing the infant gut #microbiome 💩@BCCHresearch
More: childcohort.ca/ses-breastfee…
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Turvey lab retweeted
New review: Allergy can be a genetic disease. Modi et al. show how primary atopic disorders reveal mechanisms controlling barrier integrity, immune signaling and tolerance, and inform precision therapies. From @turveylab:
hubs.la/Q04fQSwn0
#Atopy #Therapeutics
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Turvey lab retweeted
Who would have thought 30 yrs ago that there would be > 50 inborn errors of immunity underlying atopy ? This has been the most insightful study of allergy:
Primary atopic disorders: Monogenic insights into immunity rupress.org/jhi/article/2/4/…
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Mar 9
The Current with Matt Galloway - March 9, 2026: How a gene edit gave a B.C teen his life back cbc.ca/listen/live-radio/1-6…
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Turvey lab retweeted
3 Jan 2025
Stuart Turvey and colleagues @BCChildrensHosp review how the early life #microbiome shapes immune programming in childhood #asthma and #allergies: mucosalimmunology.org/articl…
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Turvey lab retweeted
4 Apr 2025
What can dirty diapers tell us about #asthma?
Clues from the gut #microbiome are reshaping how we understand pediatric asthma and allergies!
Breastfeeding, B. infantis, and early microbial exposures matter.
@WashUMedPeds #Keynote by Stuart Turvey
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Turvey lab retweeted
7 Aug 2025
ASXL1 deficiency causes epigenetic dysfunction, combined #immunodeficiency, and EBV-associated lymphoma, say Maggie Fu, Mehul Sharma, Michael Kobor, Stuart Turvey, Catherine Biggs et al.
hubs.la/Q03zN1k20
#InbornErrorsOfImmunity
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