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ITMAT @UPENN_ITMAT

ITMAT was launched formally in January 2005; the first Institute of Translational Medicine And Therapeutics in the world.

Joined April 2024
  • Tweets 254
  • Following 154
  • Followers 89
Photos and videos
Boosting the #Diagnostic rate for patients with suspected #Mendelian #GeneticDisorders doi.org/10.1016/j.gim.2026.1… @YosephBarash #GenomeSequencing #ExomeSequencing #TranslationalScience
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Integrated multimodal #Imaging, #Omics & #Clinical approaches in the Penn Medicine BioBank advance understanding of #CoronaryMicrovascular #Biology
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#CARTCell mediated desensitization strategies in #KidneyTransplant recipients at high risk of antibody-mediated #TransplantRejection nejm.org/doi/pdf/10.1056/NEJ… #CARTcelltherapy #Kidney #HLAsensitization #TranslationalScience

Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy | NEJM

HLA sensitization poses a major challenge to kidney transplantation for patients with end-stage kidney disease, especially for highly sensitized candidates. Attempts at antibody elimination (desens...

nejm.org
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Harnessing the unexpected relationship between #Endocytosis and #CARTfunction: Pairing Rab5 with CAR expression may improve CART therapy outcomes doi.org/10.1084/jem.20252564 #CARTcelltherapy #CellTherapy #CARTCell #TranslationalScience

Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels

Gu et al. show CAR T cell endocytic activity is lost after continuous tumor engagement. Introduction of Rab5 maintains functional CARs on the cell surface

rupress.org
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What are the mechanisms for NREM-to-REM sleep transitions? Check out nature.com/articles/s41593-0… #Sleep #DeepSleep #REMsleep #SleepScience #TranslationalScience

Low-dimensional population dynamics in the brainstem gate REM sleep

Nature Neuroscience - Lozano et al. show that REM sleep is gated by low-dimensional brainstem network dynamics, in which opposing neuron populations across the midbrain and pons determine when...

nature.com
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The devil is in the detail: Cautionary tale on the evaluation of #CardiacTissue exposed to #Cardioplegia doi.org/10.1073/pnas.2602039… @AranyLab #Metabolomics #CardiacMetabolism #TranslationalScience

Choice of cardioplegia influences metabolomics of human cardiac tissue | PNAS

Cardioplegia is often used prior to acquisition of human cardiac tissue to minimize warm ischemia time, which can severely confound studies of card...

pnas.org
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A #CaseReport highlights strategies to evaluate genotoxic effects associated with #AAVTherapy nejm.org/doi/full/10.1056/ne… #Mucopolysaccharidosis #MPSI #GeneTherapy #TranslationalScience

Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery | NEJM

Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we repor...

nejm.org
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Uncovering the mechanisms how flexible & dynamic nature of genome architecture is hijacked in disease doi.org/10.1016/j.molcel.202… #GenomeOrganization #FriedreichsAtaxia #FriedreichsAtaxiaNews #FACommunity #Frataxin #TranslationalScience
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Potential avenues for natural receptor ligand-based targeting of mRNA-LNPs to modify #EffectorTcell rapidly, efficiently, and transiently in vivo science.org/doi/epdf/10.1126… @EJohnWherry @WeissmanLab #mRNA #LNPs #TranslationalScience

In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs

Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming.

science.org
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New avenues to prevent and/or arrest #CerebralCavernousMalformation growth through targeting #TyrosineKinase TIE2 receptor doi.org/10.1084/jem.20251374

TIE2 links MEKK3–KLF2/4 and PI3K signaling in cerebral cavernous malformation

Endothelial cell gain of MEKK3–KLF2/4 signaling confers CCM by increasing PI3K signaling. We show that the TIE2 receptor links MEKK3–KLF2/4 and PI3K signal

rupress.org
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Targeting endothelial #NAD synthesis limits pathological #Angiogenesis doi.org/10.1016/j.cmet.2026.… @AranyLab #EndothelialCells #MetabolicRewiring #HypervascularDisease #TranslationalScience
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Advancing #Treatment options for #UnresectableHepatocellularCarcinoma by combining #TransarterialEmbolization with #PharmacologicInhibition of #Lactate dehydrogenase doi.org/10.1097/hep.00000000… @PigiLab #TranslationalScience

Locoregional lactate dehydrogenase inhibition potentiates... : Hepatology

rograms the tumor microenvironment (TME) toward glycolytic dependency, creating an opportunity to sensitize hepatocellular carcinoma (HCC) to metabolic inhibition. This study investigated whether...

journals.lww.com
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#MechanisticInsight into #ConcentricHypertrophy: Activation of different kinases in distinct #Subcellular compartments spatially regulate global #ProteinSynthesis science.org/doi/epdf/10.1126… @Prosser_Lab #Cardiomyopathy #TranslationalScience
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Cell-type-specific #EpigeneticAdaptation to support #BetaCellFunction with age nature.com/articles/s42255-0… @kaestner_klaus #DiabetesResearch #MetabolicHealth #TranslationalScience

Epigenetic adaptation of beta cells across lifespan and disease

Nature Metabolism - Mapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age and type 2 diabetes dependent adaptations and compensatory responses to...

nature.com
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Temporal regulation of #GlucoseMetabolism is governed by the endogenous #CircadianClock & less dependent on feeding rhythms doi.org/10.1371/journal.pbio… @WeljieLab #Physiology #MetabolicHealth #TranslationalScience

Glucose is dynamically regulated by time of day in humans and Drosophila

Circadian clocks are known to regulate metabolism, but the details of how they regulate glucose processing remains unclear. By integrating human metabolite profiling with isotope-tracing in Drosoph...

journals.plos.org
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Laying the groundwork for chrono-mitigatory strategies in the #HospitalEnvironment nature.com/articles/s41746-0… @CarstenSkarke @Nadimeljamal @FitzGerald__Lab #Desynchrony #Chronobiology #CircadianMedicine #TranslationalMedicine

Quantifying sleep wake rhythms in the hospital environment with digital technologies

npj Digital Medicine - Quantifying sleep wake rhythms in the hospital environment with digital technologies

nature.com
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Nine-protein #APOL1 #ProteomicRiskScore (#APRS) predicting composite outcome of ≥40% #eGFRdecline, #KidneyFailure or death to bridge gap between #GeneticSusceptibility & clinical translation nature.com/articles/s41591-0… @KSusztak #TranslationalScience

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1...

Nature Medicine - For individuals with APOL1 high-risk genotypes, which are enriched in individuals of African ancestry, a nine-protein proteomic risk score enables early prediction of kidney...

nature.com
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#MicrotubularNetwork largely mediates #CardiacRemodeling of #Cardiomyocytes in response to #MechanicalLoad doi.org/10.1016/j.jmccpl.202… #MyocardialInfarction #CardiovascularOutcomes #TranslationalScience
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The power of immersion to remodel perception of a medical discipline: doi.org/10.5435/JAAOSGlobal-… #OrthopaedicSurgery #MedicalStudent #WorkforceDevelopment #TranslationalScience

Effects of a Mandatory Orthopaedic Surgery Rotation on... : JAAOS Global Research & Reviews

uring the clerkship year would counteract stereotypes about the field. Therefore, we sought to characterize the perceptions of orthopaedic surgery before and after such a clinical rotation at our...

journals.lww.com
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Generating universal allogeneic CART (UCART) cells that evade #NKcell “missing-self” response w/ similar performance to autologous #CARTCell in vitro/vivo doi.org/10.1182/bloodadvance… #CellTherapy #ImmunoTherapy #TranslationalScience

HLA-E single-chain trimer shields gene-edited allogeneic CAR T Cells from NK cell attack

Key Points. HLA-ESP-1C single chain trimer protects gene-edited (MHC-I/II/TCR/CD54/CD58 deficient) human allogeneic CAR T cells from lysis by NK cells.Univ

ashpublications.org
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