Professor and Co-lead of DREAM, the #Diabetes Theme @DREAM_diabetes at the Children's Hospital Research Institute of Manitoba @CHRIManitoba
Joined September 2013
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Mar 16
Incretin hormones GLP-1 and GIP connect #metabolism and cardiovascular #health. Our new review highlights the latest about how endogenous incretins shape cardiometabolic disease @khushali_triv @cdnsciencepub @PhysiolPharma @UM_RadyFHS cdnsciencepub.com/doi/10.113…
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Jun 13
Building memories is energetically expensive. New research reveals that microglia help meet this demand by orchestrating a neuroimmune metabolic circuit that boosts glucose transport to active brain regions, fueling neuronal protein synthesis required for learning.
During motor learning, microglia release CYR61, linking metabolic support to synaptic plasticity and memory formation. #Neuroscience #Microglia #BrainMetabolism
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Jun 9
Disease causing mutations in each of these 11 genes are implicated in at least three different chronic diseases or lifespan in humans. #Aging #Longevity #Genetics
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Jun 8
Medium-chain triglycerides (MCTs) punch above their weight. Unlike long-chain fats that take a circuitous route, MCTs head straight from gut to the liver, rapidly fueling ketone production and improving glucose control, satiety, and energy metabolism—often with just 10–20 g/day. Emerging evidence also points to benefits for heart function, with effects varying by chain length. #Metabolism #Nutrition #CardiovascularHealth
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Considerations and best practices for respirometry dlvr.it/TSxGFq
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An important question at the University of Manitoba: What does responsible #ArtificialIntelligence mean in higher #education? @umanitoba umtoday.ca/stories/beyond-te…
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DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function dlvr.it/TSvk2z
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Jun 4
Home alone. Remote work can adversely influence mental health. A new study @ScienceMagazine
science.org/doi/10.1126/scie…
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Jun 2
A new Hormone Cell Atlas maps where hormones are made and received across 47 human tissues using 14 million single cells. The resource reveals unexpected hormone-producing cells, endocrine feedback networks, and new insights into metabolic and endocrine disease. #Endocrinology #SingleCell #PrecisionMedicine
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May 28
Retrospective cohort study: Detection of young-onset type 2 #diabetes using deep learning across primary and secondary care: Nationwide study from Denmark (n=16828 youth-onset T2D population) @TheLancet thelancet.com/journals/landi…
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May 25
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer.
✓ out the new Ground Truths (link in profile)
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May 27
REVIEW: #Metabolic syndrome and #kidney dysfunction: emerging molecular and cellular mechanisms at the metabolic–renal interface #mitochondria @FrontEndocrinol
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May 27
REVIEW: #Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for #diabetes onlinelibrary.wiley.com/doi/…
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REVIEW: #Heart Failure in Type 1 vs. Type 2 #diabetes Shared Pathways, Distinct Challenges onlinelibrary.wiley.com/doi/…
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Functional validation of a non-canonical HNF1B splice-site variant in MODY5 #diabetes @FrontEndocrinol
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May 17
Progressive HNF1A-MODY pathophysiology revealed by a translational mouse model: doi.org/10.1172/jci.insight.…
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Maternal #obesity alters adipogenic potential and #mitochondrial maximal respiration in infant mesenchymal stem cells #DOHaD @FrontEndocrinol
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🚨Excited to share our single-cell multi-omic atlas of #stemcell islet differentiation that predicts cell fate decisions and identifies causal regulators of lineage specification. You can start browsing the data now 👉 synbioelab.com/islettwin Preprint 👉 biorxiv.org/content/10.64898…
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May 19
1. Our main biomedical funding body is telling Canadian PIs its review system is collapsing. 50% increase in applications (attributed to AI but really due to PIs dealing w/ is essentially a lottery). PIs declining to review due to fatigue from turning down so much awesome science
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The fascinating biology of targeting nuclear receptor ligands to GLP-1 receptor cells continues, with the latest chapter studying GLP-1 E2 in NOD mice, with or without low dose aCD3 @DiabetologiaJnl link.springer.com/article/10…
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