Neurodegeneration Pathobiology Lab studying TDP-43, on a mission to cure #MND #ALS & #FTD. Led (and most tweets) by @adamkeithwalker. @QldBrainInst, @UQ_News.
Joined March 2017
- Tweets 935
- Following 1,004
- Followers 1,192
- Likes 1,692
95 Photos and videos
Pinned Tweet
19 Feb 2024
Very happy to see our collaborative project led by @Rebecca_SanGlia with @adamkeithwalker out today in @NatureComms, tracking proteomic changes in the cortex throughout disease in TDP-43 mice with comparison to human #ALS #FTD doi.org/10.1038/s41467-024-4…
19 Feb 2024
TDP-43-mediated neurodegeneration is complex. We show that prior to disease onset in a mouse model of ALS/FTD, cortex neurons elicit a transient increase in protective chaperones that combat TDP-43 aggregation. Read it @NatureComms:
rdcu.be/dy1PM
2
9
35
2,969
Walker Neuro Lab retweeted
1 Jun 2024
The @dehorterlab is excited to share a new study demonstrating a causal link between #immune activation, #alphasynuclein and #Parkinson onset.
This work establishes the first immune-induced model to investigate the prodromal phase of idiopathic #Parkinson.
@QldBrainInst @JCSMR
1 Jun 2024
Alpha Synuclein Induced Immune Response Triggers Parkinson's Disease Like Symptoms biorxiv.org/cgi/content/shor… #biorxiv_neursci
2
8
14
2,860
Walker Neuro Lab retweeted
2 May 2024
Today would have been Justin's 50th birthday, but as many of you know, Justin passed away last year after a long battle with MND
This weekend the Yerbury lab are taking part in the walk to defeat MND to raise vital funds to support those living with MND ⬇️
walktodefeatmnd.org.au/fundr…
2
17
731
Walker Neuro Lab retweeted
18 Apr 2024
Excellent piece on frontotemporal dementia by @AmyBrodtmann.
18 Apr 2024
Watch Dementia Australia Honorary Medical Advisor Prof Amy Brodtmann MBBS, FRACP, PhD in an on-demand webinar about frontotemporal dementia, discussing the symptoms, strategies, and support available for those impacted by FTD.
Watch now at youtu.be/sD0XpAJ1s0o?si=HA7b…
1
6
26
1,902
Walker Neuro Lab retweeted
8 Apr 2024
SAVE THE DATE!
We will be holding the 3rd Australian and New Zealand MND Research Symposium in Melbourne on Tuesday 27th and Wednesday 28th of August.
An MND Connect session will also run on the Wednesday.
Further information to come as we progress with the event.
6
12
693
8 Mar 2024
This is sad news on the outcomes of the pivotal phase 3 trial of AMX0035, which did not meet any of the primary or secondary outcome measures for people living with ALS/MND. Next steps unclear, but there are many more treatments in testing which will hopefully be more positive.
8 Mar 2024
Today, we shared the topline results from our Phase 3 PHOENIX trial. Read more in our press release: bit.ly/3TbILMC
On behalf of the entire Amylyx team, we are grateful to the ALS community and for the dedication of trial participants, investigators, and study site teams. With data collected from 664 participants in PHOENIX, we are certain there will be important learnings that will help inform future ALS research.
3
585
Walker Neuro Lab retweeted
7 Mar 2024
Trikafta — a triple small molecule combo therapy — can be considered functionally curative, though variant specific top-ups are still in play.
More of this please!
7 Mar 2024
Last year, the Make-a-Wish Foundation announced that kids with cystic fibrosis would no longer automatically qualify for a wish.
This was, actually, a good thing—a great thing even!
2
7
27
5,672
Walker Neuro Lab retweeted
21 Feb 2024
World-renowned scientist Dr. Virginia Man-Yee Lee at @PennMedicine has made groundbreaking contributions to our understanding of tau, earning her the 2024 #RainwaterPrize for Outstanding Innovation in Neurodegenerative Research, to be awarded at #Tau2024. rainwatercharitablefoundatio…
10
53
2,599
Walker Neuro Lab retweeted
22 Feb 2024
"We found several proteins that were driving disease forward and making it worse... we also found proteins that are increased early in disease and are protective."
@QldBrainInst researcher @Rebecca_SanGlia explains how her protein map could offer therapeutic pathways for #MND.
7
35
1,896
19 Feb 2024
Very happy to see our collaborative project led by @Rebecca_SanGlia with @adamkeithwalker out today in @NatureComms, tracking proteomic changes in the cortex throughout disease in TDP-43 mice with comparison to human #ALS #FTD doi.org/10.1038/s41467-024-4…
19 Feb 2024
TDP-43-mediated neurodegeneration is complex. We show that prior to disease onset in a mouse model of ALS/FTD, cortex neurons elicit a transient increase in protective chaperones that combat TDP-43 aggregation. Read it @NatureComms:
rdcu.be/dy1PM
2
9
35
2,969
19 Feb 2024
This work first initiated with support from @MND_RIA, and with vital further support from @FightMND, @racingdementia, @DementiaAus along with @nhmrc and fantastic donors to @QldBrainInst - our research couldn’t be done without it.
2
4
347
22 Jan 2024
Kicking goals @elise_kellett!
21 Jan 2024
Toxic clumps of a protein called TDP-43 are found in 97% of #MND #ALS cases.🔬
Elise Kellett has shown that toxic TDP-43 can stop other proteins from working correctly.
Investigation of the specific pathways affected could lead to new treatments.⬇️
mndresearch.blog/2024/01/18/…
11
629
15 Jan 2024
Congrats @elise_kellett - doing the lab proud!
14 Jan 2024
Congratulations to @elise_kellett, who received the Joan Lawrence Endowment Prize for High Achieving Women in Neuroscience. 💜
Elise is currently doing her #PhD in the @WalkerNeuroLab at the @QldBrainInst, researching potential therapeutic interventions in Motor Neuron Disease.
11
600
Walker Neuro Lab retweeted
14 Jan 2024
Congratulations to @elise_kellett, who received the Joan Lawrence Endowment Prize for High Achieving Women in Neuroscience. 💜
Elise is currently doing her #PhD in the @WalkerNeuroLab at the @QldBrainInst, researching potential therapeutic interventions in Motor Neuron Disease.
5
4
31
2,233
11 Dec 2023
Just out - Jane Simpson has a chat with @adamkeithwalker about MND research and why there is cause for hope, on Jane's new podcast 'Let's Talk MND' open.spotify.com/episode/0vD…
3
12
735
Walker Neuro Lab retweeted
29 Nov 2023
@TrendsNeuro 'Spotlight' by Matisse Jacobs, Rebecca San Gil & Adam Walker @WalkerNeuroLab
sciencedirect.com/science/ar…
discussing Guo et al. 2023 ‘Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies’
nature.com/articles/s41422-0…
1
2
5
911
Walker Neuro Lab retweeted
16 Nov 2023
Want to deliver gene therapies broadly, but activate them only in diseased neurons?
TDP-REG "hacks" TDP cryptic mis-splicing to drive expression only WHEN and WHERE needed! Less toxicity, wider therapeutic window, new options for sporadic ALS therapies.
biorxiv.org/content/10.1101/…
3
36
101
12,822
21 Oct 2023
Thank you to @FightMND and all the supporters for giving a thumbs up to our new collaborative project @QldBrainInst with @adamkeithwalker @samkbarton7 @Rebecca_SanGlia @DrCarlieCullen @DrCathBlizzard and co! We are eager to get started!
Introducing our third grant recipient of 2023, Dr. @adamkeithwalker from @UQscience. His project ‘Oligodendrocytes and TDP-43 pathology in MND' aims to unlock the causes and disease mechanisms of MND. We're so lucky to support the best and brightest researchers in Aus.
1
21
964
Join us on 24 October at 12pm AEDT to hear about how patient registries are helping to accelerate clinical discoveries in MND research.
Register at: fightmnd.org.au/fightmnd-sci…
1
2
976
Walker Neuro Lab retweeted
12 Oct 2023
Super proud of @JulieNecNeuro for the long journey and the massive amount of work that went into this paper. You will be missed!
11 Oct 2023
Our paper is (finally) officially published! Check out our work showing that acetylation-mimic TDP-43 impairs RNA regulation, alters protein localization and solubility, and induces behavioral deficits in aging mice. doi.org/10.7554/eLife.85921.… (1/2)
2
5
23
4,422
3 Oct 2023
Abstracts closing Oct 5 for the conference on cellular and molecular neurodegeneration #CAMAND23, to be @QldBrainInst on Dec 3-4, 2023! camand.org
Prizes and travel awards for students and ECRs - get in quick!
3 Oct 2023
Last chance to get your abstracts in for #CAMAND23 conference!!
Only 2 days before abstract submission closes
Submit at camand.org/ by 5pm, Thursday Oct 5th
@DrEleanorD @DannyHatters @MargaretSunde @anthonyjhannan
2
3
1,468