Joined April 2023
- Tweets 376
- Following 196
- Followers 527
- Likes 537
19 Photos and videos
Women in TPD & Induced Proximity retweeted
Honored to have our latest MrTAC research article featured on the Cover of Cell Chem. Here, we develop the first endogenous MrTAC and decode the rules of protein degradability, expanding tissue-specific degrader modalities.
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Women in TPD & Induced Proximity retweeted
Jan 21
Pour a glass of champagne AND red Bordeaux—Our newest work with @GSK and @scrippsresearch is out in @Nature, where we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐
nature.com/articles/s41586-0…
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Women in TPD & Induced Proximity retweeted
30 Oct 2025
She’s our greatest star of all! ⭐️ Big big congratulations to our boss 🫡
Congratulations to Dr. Christina Woo at @Harvard for receiving a Supplemental Grant! @thewoolab @HarvardCCB #DreyfusAwards
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29 Oct 2025
Congratulations to Dr. @nurkocaturk on being awarded a @WomenInTPD conference scholarship to attend the 8th Annual Hanson Wade TPD and Induced Proximity conference in Boston! 👏👏👏
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24 Oct 2025
Fantastic panel and discussion last night including @kdonovan1008 (DFCI) and organized by Lori Friedman (ORIC) at the AACR-NCI-EORTC Town Hall on "The Promise of Molecular Glues in Cancer Treatment: Will it stick?"
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24 Oct 2025
From the @bmsnews team co-led by Lynda Groocock and Deborah Mortensen comes the story of developing a BCL6 oral degrader with pM potency and excellent TGI. Fantastic work everyone!
pubs.acs.org/doi/full/10.102…
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24 Oct 2025
What can you degrade if you bifunctionalize the CRBN binder to an agnostic chemical library? Turns out a lot of proteins! Read this fascinating work below led by the talented @InesForrest , Ph.D and colleagues at Scripps on their approach using AgnoTACs.
pubs.acs.org/doi/10.1021/acs…
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Women in TPD & Induced Proximity retweeted
13 Oct 2025
The Aug-Sept Journal Club is ready!! Thanks to our amazing editors: @DeLaCuadraBaste, @_nicolamurdoch, Qinghzi, and Michael. If you are interested in the latest TPD literature, have a look!
buff.ly/JQPQrXK
#openaccess #TPD #journalclub @UoDLifeSciences
ALT Scientists, smile while looking at something. With the text "CeTPD Journal Club, August - September 2025
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6 Oct 2025
If you are in the Boston area at the end of October do not miss our free, in-person networking event on Wednesday, October 29th from 5:30-7:30pm! Thank you so much to @KymeraTx for hosting. Register below at this link:
eventbrite.com/e/women-in-tp…
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14 Sep 2025
Congratulations to the Woo lab on their new approach to gate activity using an O-GlcNac modification on the CRBN bifurcational!
12 Sep 2025
While a spoonful of sugar helps the medicine go down, glycosylated PROTACs are a nifty way to metabolically control PROTAC activity 🤩🟦🍬 Check out our newest work out now is @J_A_C_S 🫡 Congrats to Chace and all authors! 💐🎉🐱
pubs.acs.org/doi/full/10.102…
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Women in TPD & Induced Proximity retweeted
12 Sep 2025
While a spoonful of sugar helps the medicine go down, glycosylated PROTACs are a nifty way to metabolically control PROTAC activity 🤩🟦🍬 Check out our newest work out now is @J_A_C_S 🫡 Congrats to Chace and all authors! 💐🎉🐱
pubs.acs.org/doi/full/10.102…
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28 Aug 2025
Congratulations to Selina Zhang @Selina_Zh_
who has been awarded one of our conference scholarships to attend the Lorne Ubiquitin Conference in Australia! Read more about her and the exciting doctoral work in ALS she is doing below. #WomenInTPD
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Women in TPD & Induced Proximity retweeted
12 Aug 2025
Pleased to share Dr Nur Kocaturk has been awarded a Cross-Sector Experience Award from @acmedsci
This funding will allow them to collaborate with Promega Corp to co-develop a new cellular ligand finding platform for intractable disease related proteins.
ALT A person smiling
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Women in TPD & Induced Proximity retweeted
9 Aug 2025
Our evolved and engineered CRBN derivative used to enrich and visualise C-term cyclic imide-containing proteins, aka "Cerebody," is now live and in stereo in @CellChemBiol!🫡🎉💛 Congratulations to everyone behind this cool work! Huzzah! sciencedirect.com/science/ar…
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25 Jul 2025
Congratulations to Kate Stuart, Rebecca Teague, and colleagues at PhoreMost on their work towards more rational design of molecular glues! Many ways to augment the surface and binding capabilities of E3 ligases.
biorxiv.org/content/10.1101/…
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25 Jul 2025
Improvement of a DCAF1 binder that can be applied to targeted protein degradation co-led by Serah Kimani, PhD at the SGC, University of Toronto. Congratulations!
Link below:
nature.com/articles/s42003-0…
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25 Jul 2025
Congratulations to @kdonovan1008 and colleagues at DFCI on their work uncovering numerous interactors of CRBN glues!
24 Jul 2025
🧩 New paper out in Nature Communications!
"Unveiling the hidden interactome of CRBN molecular glues"
Huge thanks to our incredible team and collaborators who made this possible!
📖 Read the full open-access article here: nature.com/articles/s41467-0…
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Women in TPD & Induced Proximity retweeted
20 Jul 2025
We hope everyone is as in love with this cover as we are! 🤩
20 Jul 2025
💚My New Cover for @thewoolab @Harvard 💙
This art illustrates the discovery that #cereblon, a key protein in the cell’s waste disposal system, recognizes small chemical tags called #cyclic_imides (shown here in green at the tips of proteins). These naturally form at the end of #damaged_proteins and resemble the structure of #thalidomide, a drug with a complex legacy…
📍Originally used as a sedative in the 1950s, thalidomide became infamous for causing severe birth defects when taken during pregnancy… Because it’s dreadful effects during pregnancy were not assessed during trails… Only decades later, it was found to bind #cereblon and alter its function. Today, thalidomide and its modern relatives are used in #cancer_therapies because they redirect cereblon to degrade disease-related proteins📍
The study shows that #cereblon doesn’t just respond to drugs like thalidomide, it also recognizes similar structures that arise during protein damage. These cyclic imide #degrons could be harnessed to design new treatments that guide cereblon to target harmful proteins!
🔗 doi.org/10.1021/acs.accounts…
#sciart #science #scientific_illustration #chemistry #medicine #ellamaru #sciencegirl #sci_artist #sci_design #cover #scientific_cover #medicalartist #phd #phdlife
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Women in TPD & Induced Proximity retweeted
1 Jul 2025
Super grateful for the generous support from Esther A. & Joseph Klingenstein Fund! We are excited to make more discoveries uncovering the roles of the midnolin-proteasome pathway in neurons!
1 Jul 2025
Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System." @XinGu0317
xingulab.dana-farber.org
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Women in TPD & Induced Proximity retweeted
17 Jun 2025
So happy and proud to see our story online!! Thank you, the midnolin team!
17 Jun 2025
Online Now: Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma dlvr.it/TLPfxk
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