PhD
Joined February 2020
- Tweets 21
- Following 80
- Followers 42
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1 Photos and videos
May 12
New preprint from our team @chiluncellbio : OPA1 doesn’t just regulate mitochondrial fusion — a subpopulation localizes to lipid droplets and actively controls fatty acid release.
biorxiv.org/content/10.64898….
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May 12
We show:
1) Exon 4 encodes an amphipathic helix that targets OPA1 to LDs
2) LD-localized OPA1 recruits lipases and promotes FA release
3) LD targeting competes with mitochondrial localization and alters mitochondrial connectivity
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May 12
4) The OPA1 S158N variant attenuates FA release and associates with metabolic traits in pediatric cancer survivors.
These findings uncover an unexpected mitochondria–lipid droplet regulatory axis linking OPA1 to human metabolism.
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Xiao Li retweeted
2 Jul 2024
.@XiaoLinichd, Gamuyao, @chiluncellbio et al. @stjuderesearch engineer a #LipidDroplet (LD)-targeting motif and develop a tool kit that can track contact sites between LDs and other organelles in living cells. hubs.la/Q02F1yfK0
@Daniel_Stabley @alexcarisey @agtebo
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Xiao Li retweeted
30 Nov 2023
We are thrilled to introduce FABCON, a “Fluorogen-Activated Bimolecular complementation at CONtact sites” tool kit for interrogating lipid droplet-organelle interaction and beyond in living cells.
biorxiv.org/content/10.1101/…
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Xiao Li retweeted
1 Mar 2023
A postdoctoral position in microbial pathogenesis is available in the Machner Lab at NIH.
Help us determine how Legionella pneumophila modulates host cells during infection.
For more details go to
nichd.nih.gov/research/atNIC…
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23 Nov 2022
Interested in how a Legionella phospholipase effector and phospholipids regulate pathogen-containing-vacuole expansion within host cells? Check out our @MatthiasMachner paper! Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pnas.22…
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Xiao Li retweeted
10 Oct 2022
Job Alert!
We are hiring postdocs & scientists to interrogate the subcellular spatial organization of metabolism! These positions are supported by DP2 award @NIH_CommonFund and @StJudeResearch offering amazing training opportunities, generous salary/benefits, and GREAT science!
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Xiao Li retweeted
22 Aug 2022
The Chang lab @stjuderesearch is looking for highly motivated postdocs and scientists to join us!
We apply innovative tools and approaches to interrogate the dynamic spatial organization of inter-organelle logistics. Details here, stjude.org/research/labs/cha…
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