Worth noting genetic manipulations that robustly increase longevity in mice are not naturally occurring. They would be strongly selected against. Absence of such variants from the gene pool is *expected* in humans. That does not mean such variants would not increase longevity.
Of course human longevity genes exist. This is basic genetics and well-established. Are there are single gene effects on longevity in humans similar, in either relative or absolute terms, to those in mice? We don't know, and anyone who claims otherwise is not credible.