Postdoc in theoretical biology @kokkonutter @uni_mainz. Evolution & development, gene regulation, symbiosis, health & disease. And a fondness for the humanities
Joined August 2019
- Tweets 3,216
- Following 3,164
- Followers 748
- Likes 8,321
88 Photos and videos
Roman Zug retweeted
15 Nov 2024
Check out our new ✨preprint✨ led by James Schmidt! Here we identified a new role for the gene KANSL1 in ciliary biology using Xenopus, with validations in patients with associated Koolen-de Vries Syndrome, which is characterized by hypersociability.
biorxiv.org/content/10.1101/…
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Roman Zug retweeted
13 Nov 2024
Registration is open for a Symposium on “Cells and Embryos: #NotInTheGenes” in La Pedrera, Barcelona. 18/19 of September 2025.
Attendance is free but you need to register shorturl.at/77Wqn
Stembryo lab @UPFbiomed @ERC_Research
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Roman Zug retweeted
9 Nov 2024
🧵 I am very excited to share my postdoc project preprint investigating the role of NR4A2, a transcription factor linked to neuropsychiatric disorders, in the establishment of cell type identities in the claustro-insular region of the brain. 1/9
biorxiv.org/content/10.1101/…
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Importantly, it is IRF6's own enhancer that gets disrupted, thereby perturbing the positive feedback loop needed for proper IRF6 expression levels.
This is further evidence showing that disrupted positive feedback can lead to developmental disorders: bit.ly/48ILWTz
7 Nov 2024
GWAS of non-syndromic cleft palate in 228 cases and 300k controls from Finland. The striking signal in chromosome 1 is driven by a noncoding variant near a transcription factor IRF6 disrupting an enhancer. The variant is 19 times more frequent in Finns than other Europeans.
Rahimov et al. Nat Comm
nature.com/articles/s41467-0…
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Roman Zug retweeted
8 Nov 2024
My take on scientists leaving Twitter/X: It's great to see communities really developing on other platforms and there are lots of good reasons to boycott this place... 1/n
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Roman Zug retweeted
8 Nov 2024
I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1).
nature.com/articles/s41580-0…
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Roman Zug retweeted
6 Nov 2024
Welche „gemeinsamen Überzeugungen“ hat eine Ministerin für *Bildung und Forschung* mit einem Donald Trump, der paradigmatisch für die Verachtung der Wahrheit steht? #Bullshit
6 Nov 2024
Die 🇺🇸 #USA gehören zu unseren wichtigsten Verbündeten. Ich gratuliere dem neuen Präsidenten Donald Trump und wünsche ihm viel Erfolg im Sinne unserer gemeinsamen Überzeugungen. 🇩🇪 und 🇪🇺 müssen nun umso dringlicher ihre wirtschafts- & sicherheitspolitischen Hausaufgaben angehen.
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Strong evidence of reduced NPAS3 expression in modern humans due to loss of enhancer function!
Further support for the hypothesis that loss-of-function of genes involved in brain development was important for human evolution:
tinyurl.com/2p6aarkc
academic.oup.com/mbe/article…
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Roman Zug retweeted
31 Oct 2024
30 Oct 2024
Cyclocosmia latusicosta from the North of Vietnam.
One of the most spiders with the strangest ass with a demon face or something. This is a real spider !!!
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In fact, I discussed many of the "unsuspected links" between phase separation and transcription factor haploinsufficiency in my 2022 review...
journals.biologists.com/bio/…
26 Oct 2024
Emerging links between phase separation and transcription factor haploinsufficiency dlvr.it/TFmJSs
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Roman Zug retweeted
9 Oct 2024
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum. Check out the study led by @IMBA_Vienna @Knoblich_lab in @CellStemCell #SfN24 hubs.li/Q02R-Qrn0
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Roman Zug retweeted
7 Sep 2024
Our new paper by Hiroshi Arai et al. has been published!
Cell-based assays and comparative genomics revealed the conserved and hidden effects of Wolbachia on insect sex determination academic.oup.com/pnasnexus/a…
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Roman Zug retweeted
6 Sep 2024
Das hier ⬇️ ist der Endgegner. Nicht das bisschen #Migration
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Roman Zug retweeted
6 Sep 2024
This nasty pathogen infects the nuclei of mussels, multiplies to >80000 cells, swelling nuclei to >50 times their size. Where does its nutrition come from? How does it avoid apoptosis? Read our paper, just out!
nature.com/articles/s41564-0…
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Roman Zug retweeted
5 Sep 2024
The german leader of the opposition stoking up an anti-immigration debate to appease the far right.
This is dangerous and irresponsible and usually ends with the self-destruction of the centre right.
Has he not seen what happened to the Tories or his sister parties in France?
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Roman Zug retweeted
2 Sep 2024
I couldn’t even tweet yesterday when I saw the results in Thuringia and Sachsen.
This was so predictable.
Germany is sleep walking into the abyss, while insisting on a balanced budget in the middle of the worst economic crisis since the 1990s.
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Roman Zug retweeted
31 Aug 2024
Uh no they can't, this would be the hugest news in psychiatry for a hundred years. Much microbiome stuff is horribly flawed. Sometimes some (bad) studies find correlations across groups, but even those wouldn't have sufficient predictive power to identify schiz or depression
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