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Joseph Watson @_JosephWatson
Joined September 2020
  • Tweets 129
  • Following 95
  • Followers 3,015
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Joseph Watson@_JosephWatson
28 Feb 2025
I’m excited to share our significantly-updated preprint on de novo antibody design, where we now demonstrate the structurally accurate design of scFvs (in addition to VHHs) with RFdiffusion! biorxiv.org/content/10.1101/…
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I’m excited to share our significantly-updated preprint on de novo antibody design, where we now demonstrate the structurally accurate design of scFvs (in addition to VHHs) with RFdiffusion! biorxiv.org/content/10.1101/…
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In particular, thank you to the other lead authors, @naterbennett0, @RobertRagotte, @AndrewJBorst, @dejsee, Connor Weidle, @wanderingriti and Yutong Yu! And thanks as always to David Baker for the leadership and for creating such a vibrant and exciting scientific environment!
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Finally, for the past year or so, some of us have been working to build the next generation of these tools at Xaira Therapeutics (@Xaira_Thera), with the aim of fully realising the promise of therapeutics design. If you’re interested in being a part of it, do get in touch!
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All the big things happening to all the best Davids! Congratulations David 😍
David Juergens@DaveJuergens
10 Oct 2024
⚛️ I got a new job ⚛️ After 5 wonderful years at @UWproteindesign and @UWMolES, I’m headed to Palo Alto for a postdoc at @StanfordUChem under Todd Martinez. SUPER excited to dive into deep learning for quantum chemistry and explore the Bay Area!!
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Congratulations to all - incredibly deserved! It was a total and constant honour working with David. His passion for protein design and its applications, as well as his uncanny attention to detail continue to inspire me. And nothing we do today would be possible without AlphaFold
The Nobel Prize
@NobelPrize
9 Oct 2024
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Very exciting to see this work out! It still feels quite amazing that you can take three functional bits of protein and bring them all together with novel scaffolds, all while retaining their native function. Congratulations to @karla_mcastro for leading this super cool project!
Bruno Correia@befcorreia
11 May 2024
protein design is getting weird ... and increasingly functional ! These are very weird designs ! biorxiv.org/content/10.1101/… fun collaboration with @karla_mcastro @_JosephWatson @jueseph @UWproteindesign
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A great day for science! Congratulations to the teams at @GoogleDeepMind @IsomorphicLabs!!
Google DeepMind
@GoogleDeepMind
8 May 2024
Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵 dpmd.ai/3URDiNo
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Joseph Watson retweeted
Brian L Trippe@brianltrippe
6 May 2024
I am pleased to share that I have accepted a position @Stanford to start as an assistant professor in the department of statistics, with an affiliation in @StanfordData, this fall!
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I'm excited to announce that I'm part of the team at Xaira Therapeutics! This project has been some time in the making. I'm convinced that generative modelling, and ML for biology more generally, will play a pivotal role in the next generation of therapeutics. 1/2
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We're extremely grateful and excited to have the backing to try and realise this vision! I'm very excited to work with our growing team of amazing people in the UK and US. Read more about the project here: endpts.com/in-biggest-ever-b…

Exclusive: In $1B bet on AI, biopharma heavyweights back new startup to upend drug R&D

A star-studded mix of venture capitalists and scientists, backed by more than a billion dollars, is launching an ambitious biotech that aims to reinvent drug R&D using artificial intelligence, the ...

endpoints.news
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Joseph Watson retweeted
Emile Mathieu@MathieuEmile
24 Apr 2024
Replying to @CalSleeper
@CalSleeper really love travelling on your sleeper trains! Why not allow for booking 1 berth in cabins whilst keeping the option to book the full cabin? Would increase the number of people who could travel by train instead of flying! Feels quite a waste of berths atm 🤷‍♂️
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Congrats to my amazing PhD supervisor Manu!!
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Joseph Watson retweeted
Jason Yim@json_yim
6 Apr 2024
Our review on diffusion models for protein structures and docking is out @HannesStaerk @GabriCorso Bowen Jing @BarzilayRegina Tommi Jaakkola. This summarize the advancements up to 2023. There have been lots of exciting new works since! wires.onlinelibrary.wiley.co…

Diffusion models in protein structure and docking

Applications in structural biology where diffusion models are state-of-the-art. We illustrate diffusion processes comprised of a forward (noising) and reverse (sampling) direction. The diffusion...

wires.onlinelibrary.wiley.com
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