Head of Electron Microscopy, Institute for Protein Design @UWproteindesign, University of Washington @UW
Joined April 2014
- Tweets 287
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30 Photos and videos
28 Feb 2025
Our updated preprint, "Atomically accurate de novo design of antibodies with RFdiffusion" is now available on BioArchive, now including scFvs!!
biorxiv.org/content/10.1101/…
Shout-out to all our collaborators and co-lead authors. Computational antibody design and validation is HERE!
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28 Feb 2025
In particular, thank you to the other lead authors, @_JosephWatson, @naterbennett0, @RobertRagotte, @dejsee, Connor Weidle, @wanderingriti, and Yutong Yu!
This project is a testament to how computational and experimental science work together, each driving the other forward.
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Andrew Borst retweeted
9 Dec 2024
Looking for a primer on why the contrast transfer function matters in #cryoEM?
Have a look at our updated #CryoSPARC Guide pages on CTF estimation! We cover intuition, theory, job types and practical considerations: guide.cryosparc.com/processi…
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4 Dec 2024
Excited to share our latest pre-print! 🌟 Collaboration between @UWproteindesign & @NIH tackles the global threat of #influenza & the need for #H5N1 countermeasures. #CryoEM reveals how conserved motifs & water molecules help achieve broad protection.
biorxiv.org/content/10.1101/…
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18 Sep 2024
Excited to share our latest pre-print outlining a successful use case of #ModelAngelo and protein BLAST in helping us solve a tricky protein purification challenge in computational #ProteinDesign!
@UWproteindesign @UWBiochemistry @cryoEM_Papers
biorxiv.org/content/10.1101/…
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18 Sep 2024
Big congratulations to Kenneth Carr and Dane Evan Zambrano, who co-led this study! 🎉 A special thank you to the developers of #ModelAngelo —this incredible tool was crucial to our success. Our designed proteins thank you! 👏
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18 Sep 2024
Thanks to #CryoEM, #ModelAngelo', #BLAST, and #AlphaFold 3 predictions, we identified and modified our purification protocol to remove dihydrolipoamide succinyltransferase (hashtag#DLST) from our preps.
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18 Sep 2024
We faced an issue with a unknown octahedral nanoparticle-like protein co-purifying with a number of our designed protein nanomaterials.
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Andrew Borst retweeted
3 Apr 2024
How is the human adaptive immune system responding to MERS-CoV infection? Find out by reading our @biorxivpreprint led by @AminAddetia
@HHMINEWS
@UWBiochemistry
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biorxiv.org/content/10.1101/…
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Andrew Borst retweeted
CrAI, a tool using machine learning to automatically find antibodies in cryo-EM densities, is now available in ChimeraX (menu Tools / More Tools)! CrAI runs in seconds on a CPU, at resolutions up to 10A. Learn more at cxtoolshed.rbvi.ucsf.edu/app…
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Andrew Borst retweeted
19 Mar 2024
We’re really happy to share our preprint demonstrating the atomically-accurate design of single-domain antibodies (VHHs) with RFdiffusion!
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Andrew Borst retweeted
19 Mar 2024
Atomically accurate de novo design of single-domain antibodies biorxiv.org/cgi/content/shor… #bioRxiv
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19 Mar 2024
Excited to share the release of our pre-print unveiling the design of de novo single-domain #antibodies with atomic-level precision, as revealed by #CryoEM! @UWBiochemistry @UWproteindesign
Work co-led by @_JosephWatson @naterbennett0 @RobertRagotte
biorxiv.org/content/10.1101/…
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19 Mar 2024
I'd also like to express immense gratitude to my dedicated IPD Electron Microscopy Research Core team, Connor Weidle and Kenneth Carr, for their incredible contributions to towards this effort.
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19 Mar 2024
A heartfelt congratulations to all co-authors, with special recognition to the other lead authors, @_JosephWatson, @naterbennett0, and @RobertRagotte for their outstanding leadership driving this project.
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Andrew Borst retweeted
19 Mar 2024
We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!
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Andrew Borst retweeted
18 Oct 2021
We're hiring a Research Assistant (full-time, Seattle WA).
Main duties include protein characterization and electron microscope operation. Experience in protein structural biology is highly desired. Bachelor's degree required.
Learn more: ipd.uw.edu/employment
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Andrew Borst retweeted
23 Sep 2021
I am honored to have been selected by @HHMINEWS to become part of the #HHMIInvestigators family. Grateful to my previous mentors as well as past/current trainees and collaborators. I am so excited about the science ahead of us!
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Andrew Borst retweeted
31 Mar 2021
I’m happy to announce that effective April 15, every adult in Washington will be eligible to receive a COVID-19 vaccination.
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Andrew Borst retweeted
10 Feb 2021
Pleased to share our latest paper: "Complete and cooperative in vitro assembly of computationally designed self-assembling protein nanomaterials" @NatureComms. Featuring brilliant native mass spec from @hecklab
rdcu.be/ce1KJ
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