SARS Cov 2 has many redundant ways of hiding from cd8 T cells
Did not expect so many!
So the T cells are at a disadvantage
What about viral genes in addition to ORF8 in controlling MHC I expression? Remarkably, many other viral genes (E, M, ORF7a,b) reduced MHC I just as well as HIV-nef (gold standard)! These SARS-CoV-2 genes, to a lesser extent, reduced MHC II expression also. (9/)