I’m seeing some dangerous trends in “longevity medicine” and biohacker culture as doctors, pharmacists, and influencers push the edges of what’s legal and ethical. Here’s one example 👇 Unscrupulous marketers are selling research-grade chemicals while packaging them to look like benign dietary supplements. That design choice isn’t accidental. It’s meant to make people think these compounds are safe, tested, and appropriate for human use, when many are not. SLU-PP-332is a good case study. Despite sometimes being called a “peptide,” it’s actually a small-molecule drug with no human safety or efficacy data. It has only been tested in a handful of mouse studies. Yet it’s being promoted as an “exercise mimetic,” and some clinicians are even illegally prescribing it. Do a quick Google search and you’ll find plenty of sketchy sites selling “research-grade” SLU-PP-332. Don’t buy it. If you wouldn’t take the brown Sigma-Aldrich bottle and sprinkle it on your yogurt, why would you trust the exact same chemical sold by a fly-by-night internet vendor, encapsulated with unknown purity and zero oversight? I tend to be libertarian when it comes to healthcare - people should be free to make choices about their own bodies if they’re fully informed. This isn’t informed choice. It’s deceptive opportunism that puts real people at risk. Choose evidence over aesthetics. Science over marketing.

Upcoming RCCN Webinar! In this webinar, the speakers will discuss how potential bias in the data used to train AI models can potentially negatively impact outputs, and how to address data bias. Learn more and register here: bit.ly/440SQ5C

We are proud to feature 2025 RCCN Pilot Awardees Lauren Ferrante and Kathryn Callahan in this Pilot Awardee Spotlight! Learn more about their Inter-NIA Center pilot project here: bit.ly/4izqwNF #Frailty #AgingResearch

ICYMI: Many of the recordings and slides from our recent workshop are now available on the RCCN website here: bit.ly/3M8BNsa #ADRDResearch #AgingResearch

Thank you to all who joined us in-person and online for the RCCN Workshop "Innovative Perspectives to Advance AD/ADRD Multidisciplinary Research" on Nov 11-12, 2025! We look forward to sharing presentation recordings and slides soon.

🧠 New in GeroScience! “Age, glucose tolerance, and cognitive performance in female vervet monkeys” by Brett M. Frye (@brettmfrye) & Carol A. Shively (@1749_336) et al. Key insights: 📍In middle-to-older aged female vervet monkeys, age was strongly associated with higher fasting glucose, impaired glucose clearance, and reduced insulin area-under-the-curve. 📍Animals with worse glycemic control over time showed poorer executive function and a trend toward weaker working memory. 📍These findings highlight a link between metabolic aging and cognitive decline in a primate model, reinforcing the importance of metabolic health for brain aging. 🔗 rdcu.be/ePbFU #CognitiveAging #Metabolism #NonHumanPrimates #VervetMonkey #HealthyAging

Depression is not a “thing”. It is a label for a range of dynamic, energetic states that manifest across the body-mind unit.

Geroscience: A Translational Review "Therapies that inhibit aging biology, such as caloric restriction, metformin, senolytics, or rapalogs, may slow the development and progression of disease and functional decline in humans." @agingup, Steven Cummings jamanetwork.com/journals/jam…

Geroscience: A Translational Review | Nutrition, Obesity, Exercise | JAMA | JAMA Network jamanetwork.com/journals/jam…

Geroscience is reshaping medicine—targeting aging biology (via caloric restriction, metformin, rapamycin, senolytics) may delay multiple age-related diseases at once. A new @JAMA_current review explores the science, promise, and clinical frontiers.jamanetwork.com/journals/jam…

Relationship of Visual Impairment and Poor Mobility With Mortality. #geriatrics agsjournals.onlinelibrary.wi…

Associations Between Inflammation and Multisensory Impairment Among Older Adults. #geriatrics agsjournals.onlinelibrary.wi…

📢Newly Published Open🔓 Access Article Development of a multimorbidity health conditions outcome index for caloric restriction interventional studies in older adults: a preliminary investigation in an observational cohort study by Michael E. Miller & Stephen B. Kritchevsky (@agingup) et al. link.springer.com/article/10… #olderadults #caloricrestriction #Compositeoutcomes

My team at RAND is hiring! Technical analysis for AI policy is desperately needed. Particularly keen on ML engineers and semiconductor experts eager to shape AI policy. Also seeking excellent generalists excited to join our fast-paced, impact-oriented team. Links below.

Sense of purpose emerges as key predictor of cognitive functioning in older adults. news.google.com/rss/articles…

Connecting Body and Brain - ADRD-related biomarkers and physical performance in cognitively normal older adults. doi: 10.1093/gerona/glaf110

Analysis from the Health, Aging and Body Composition Study: Visual impairment (VI) predicts greater declines in physical performance over time. Adults with VI may benefit from mobility intervention. @WakeForest @agingup #NEIfunded @SpringerNature: bit.ly/4jjLq2y

Upcoming Webinar! "Overview of NIA Supplements that Support Researchers Through Major Life and Career Events" will give an overview of several types of administrative supplements offered by NIA, and the application and review process. Learn more: bit.ly/4csYjVJ

Relationship of multiple sensory impairments with physical performance in older adults in the Study of Muscle, Mobility and Aging | @agingup "Greater SIs were associated with worse physical performance in older adults, and the association was partially mediated by measures of cognitive processing speed and executive function." pubmed.ncbi.nlm.nih.gov/4015…