Bioinformatics/psychiatric genetics PhD candidate @CompMedUCLA | @ucla CompBio Math alum | Here mainly for science NBA twitter & geography memes. (he/him)
Joined November 2014
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Excited to see our work in AJHG! Thank you to our amazing co-authors, UCLA Institute for Precision Health, UCLA CTSI, and our collaborators for the support with this work. Above all, we are grateful to the patients and ATLAS biobank participants at @UCLAHealth.
🧬New today!
đź“„Inclusion bias affects common variant discovery and replication in a health-system linked biobank
🧑‍🤝‍🧑 @loldeloo @apimplaskar @bpasaniuc & co
cell.com/ajhg/fulltext/S0002…
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May 18
FastGxC: Fast and powerful context-specific eQTL mapping in bulk and single-cell data dlvr.it/TSbgrB
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Interpretability has not kept up with scaling LLMs at all, especially for *knowledge*. But here's a wild idea:
using cross-lingual knowledge inconsistency (typically seen as a "bug") as a tool for dissecting where knowledge lives
🧵1/4 arxiv.org/abs/2603.17102 @GoogleResearch
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New preprint! We mapped thalamocortical dynamics in human focal epilepsy using SEEG. We found distinct spectral and connectivity based signature that could be direct targets for neurostimulation.
With @UCLAMCH and @uclamii
medrxiv.org/content/10.64898…
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22 Oct 2025
"An hour of planning can save you 10 hours of doing."
✨📝 Planned Diffusion 📝 ✨ makes a plan before parallel dLLM generation.
Planned Diffusion runs 1.2-1.8× faster than autoregressive and an order of magnitude faster than diffusion, while staying within 0.9–5% AR quality.
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15 Oct 2025
Excited to visit Boston for #ASHG25. I’ll be presenting our work on the effects of recruitment bias in biobank studies on Friday (10/17) @ board 1126 — please drop by and say hi!
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15 Oct 2025
Would love to connect/discuss projects w/ folks interested in EHR-based phenotyping methods for genetic studies, psychiatric genetics, and perinatal health!
#ASHG25
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18 Sep 2025
🔦Adaptive Parallel Decoding (APD) has been accepted as a spotlight paper at @NeurIPSConf ! I thank my collaborators, reviewers, and program organizers for this honor.
A thread for those interested 🧵 (1/n)
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8 Sep 2025
Our work on genetic variants that affect RNA stability is out in @NatureGenet! We present the RNAtracker computational pipeline, which can distinguish between transcriptionally- vs. stability-mediated regulation of gene abundance. bit.ly/42aihk2 (1/n)
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đź“ŁNew from @bpasaniuc & co
đź“„Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
cell.com/ajhg/abstract/S0002…
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13 Feb 2025
“That’s one small [MASK] for [MASK], a giant [MASK] for mankind.” – [MASK] Armstrong
Can autoregressive models predict the next [MASK]? It turns out yes, and quite easily…
Introducing MARIA (Masked and Autoregressive Infilling Architecture)
arxiv.org/abs/2502.06901
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10 Feb 2025
Does ambient RNA/DNA confound the genotype-based demultiplex of 10x Multi-ome data? Terence Li @terencewtli, a bioinfo grad student in Noah Zaitlen lab and my lab investigated precisely this question and provided practical recommendations.
9 Feb 2025
The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments biorxiv.org/content/10.1101/… #biorxiv_bioinfo
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9 Feb 2025
The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments biorxiv.org/content/10.1101/… #biorxiv_bioinfo
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15 Oct 2024
Online Now: Single-cell stimulus-response gene expression trajectories reveal the stimulus specificities of dynamic responses by single macrophages dlvr.it/TFMykR
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📢Online now!
đź“°Splicing-specific transcriptome-wide association uncovers genetic mechanisms for #schizophrenia
🧑‍🤝‍🧑@gracexiao99 @bpasaniuc & colleagues
cell.com/ajhg/fulltext/S0002…
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25 Apr 2024
Excited to share that our paper: "Uncovering spatiotemporal dynamics of the corticothalamic network at ictal onset" is out in Epilepsia!
with Hiroki Nariai, Atsuro Daida, Shingo Oana, @BillSpeier, @uclachildneuro, et. al
bit.ly/3walCTu
(1/4)
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9 Feb 2024
Settle a debate for me (and some friends): is a tent flap considered a door?
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9 Feb 2024
I’ve been advised to put up a poll
71%
Door
29%
Not a door
28 votes • Final results
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7 Dec 2023
My first first author paper is now online with @BiologicalPsyc1! We compared two sets of MDD symptoms and found that current symptoms collected by PHQ9 are meaningfully different from lifetime symptoms collected through CIDI-SF. (1/n)
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