Kidney Cancer surgeon/scientist @MSKCancerCenter . Co-leader of Translational Kidney Cancer Program and Assistant PD @urologymsk Tweets my own.
Joined February 2009
- Tweets 855
- Following 482
- Followers 1,365
- Likes 1,797
112 Photos and videos
ari hakimi retweeted
Congratulations to Dr. Martin Weiser, who has been selected to serve serve as the next Chair of the Department of Surgery at MSK.
Dr. Weiser currently holds the Stuart H.Q. Quan Chair in Colorectal Surgery, is a world-renowned academic colorectal surgeon, and has held a number of important leadership roles in his 25 years on the faculty at MSK, including serving for the past 10 months as the Acting Department Chair.
Join us in welcoming Dr. Weiser to the role of Chair of the Department of Surgery by commenting below. š
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Why do VEGFR-TKI IO combinations produce impressive responses in ccRCC but often fail to achieve the long-term durability seen with dual checkpoint blockade? Check out our lab's latest in @Cancer_Cell led by the incredible Lyn Vuong!
cell.com/cancer-cell/fulltexā¦
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Across clinical trials and real-world cohorts, pretreatment hypoxia predicted poorer outcomes. In contrast, on-treatment hypoxia-associated TAM programs reflected therapeutic activity. Timing matters: baseline hypoxia and treatment-induced hypoxia are biologically distinct.
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Conclusion: ccRCC begins as a pseudohypoxic, vascular tumor. VEGFR-TKIs trigger hypoxia, driving tumor control and recruitment of SPP1āŗ TAMs. However, persistent hypoxia can ultimately promote resistance and mets linking response and failure through the same biological process.
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Single-cell profiling revealed distinct immune effects of VEGFR-TKI and immunotherapy. Both remodeled the TME, but ICI preferentially expanded T-cell responses while TKI induced a unique myeloid and B-cell response program, suggesting complementary mechanisms of action.
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Next came our main finding: SPP1āŗ/GPNMBāŗ macrophages emerge in response to true tissue hypoxia. These cells are rare in untreated tumors but accumulate after VEGFR inhibition, providing a biomarker that distinguishes genuine hypoxia from VHL-driven pseudohypoxia.
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A bittersweet honor to be the Maria Becerra visiting Professor at @dsui_miami_uro . Amazing group of residents and faculty!
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ari hakimi retweeted
Thank you to my outstanding mentors, both past and present. @mouwlab @MattMossanen @RichMatulewicz @eugene_pietzak @DSolit @arihakimi @UrologyMSK
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ari hakimi retweeted
Really awesome poster by urologic oncology fellow extraordinaire @VinceDAndreaMD with @DrDarrenFeldman @DSolit #SamFunt on genomic determinants of cisplatin resistance in germ cell tumors!
@MSKCancerCenter @UrologyMSK @MSK_DeptOfMed
@ConquerCancerFd @ASCO #ASCO26
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ari hakimi retweeted
May 18
Now published in @ScienceMagazine by @UrologyMSK @arihakimi et al:
Sensitive CAR T cells redefine targetable CD70 expression in solid tumors
science.org/doi/10.1126/scieā¦
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Truly a privilege to work with such a rising āļø!!
Thrilled to receive the Gerstner Physician Scholarsā grant!
The grant will support our work for the next 3 years on mitochondrial DNA mutations in cancer.
Very thankful for the mentorship from Craig Thompson, @EdReznik, @motzermd, @arihakimi and many others!
@MSK_DeptOfMed
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ari hakimi retweeted
Thrilled to receive the Gerstner Physician Scholarsā grant!
The grant will support our work for the next 3 years on mitochondrial DNA mutations in cancer.
Very thankful for the mentorship from Craig Thompson, @EdReznik, @motzermd, @arihakimi and many others!
@MSK_DeptOfMed
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ari hakimi retweeted
Mar 27
Special to celebrate the retirement of the legendary Pramod Sogani after his 54 (!!) year career at @MSKCancerCenter! Amongst his many accomplishment Dr Sogani served as president of the @AmerUrological
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ari hakimi retweeted
Iāve heard concerns about @theNCI funding in FY26āespecially about the number of awards issued so far. Hereās some context. š§µ
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ari hakimi retweeted
š§µ During todayās National Cancer Advisory Board (#NCAB) meeting, I shared updates on where NCI standsāand where weāre headed.
I see a research enterprise that is steady, focused, and ready to accelerate progress against cancer.
Here are a few highlights:
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